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  • BDD Moderators: Keif’ Richards | negrogesic

The Official Tramadol Discussion Thread

Yeah, I know what you mean.
I use them to hop off the hydrocodone wagon for a bit every now and then.

Also, to filter pills with thay much filler you need a .5 micron filter first, then run it through a .2 after that, you should have no problems.
 
You fellas call it whatever you like, I'll stick with opioid what with it being an opioid and all that ;)

NSFW:
alpha(2)-adrenoceptor agonists like clonidine or dexmedetomidine increase the sedative and analgesic actions of opioids. Furthermore opioids like meperidine show potent anti-shivering effects like alpha(2)-adrenoceptor agonists. The underlying molecular mechanisms of these effects are still poorly defined. The authors therefore studied the ability of four different opioids (meperidine, remifentanil, sufentanil and tramadol) to interact with different alpha(2)-adrenoceptor subtypes in mice lacking individual alpha(2A)-, alpha(2B)- or alpha(2C)-adrenoceptors (alpha(2)-adrenoceptor knock out (alpha(2)-AR KO) mice)). The interaction of opioids with alpha(2)-adrenoceptors was investigated by quantitative receptor autoradiography in brain slices of alpha(2A)-, alpha(2B)- or alpha(2C)-adrenoceptor deficient mice. Displacement of the radiolabelled alpha(2)-adrenoceptor agonist [(125)I]-paraiodoclonidine ([(125)I]-PIC) from alpha(2)-adrenoceptors in different brain regions by increasing opioid concentrations was measured, and binding affinity of the analysed opioids to alpha(2)-adrenoceptor subtypes in different brain regions was quantified. Meperidine, remifentanil and tramadol but not sufentanil provoked dose dependent displacement of specifically bound [(125)I]-PIC from all alpha(2)-adrenoceptor subtypes in cortex, cerebellum, medulla oblongata, thalamus, hippocampus and pons. Required concentrations of meperidine and remifentanil for [(125)I]-PIC displacement from alpha(2B)- and alpha(2C)-adrenoceptors were lower than from alpha(2A)-adrenoceptors, indicating higher binding affinity for alpha(2B)- and alpha(2C)-adrenoceptors. In contrast, [(125)I]-PIC displacement by tramadol indicated higher binding affinity to alpha(2A)-adrenoceptors than to alpha(2B)- and alpha(2C)-adrenoceptors. Our results indicate that meperidine, remifentanil and tramadol interact with alpha(2)-adrenoceptors in mouse brain showing different affinity for alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptors. In contrast, the micro-agonist sufentanil did not show any alpha(2)-adrenoceptor interaction. These effects may have an impact on the pharmacologic actions of these opioids.
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Sufentanil appears to be the odd one out of this random study of the effects of various opioids. Tramadol may pack a wee bit less punch than fent analogues but it's still a cousin opioid.

I don't think of it as weak either. And I've had plenty to compare it with :)
 
Im getting alot of the shitty effects from long term high dose tram use... not sleeping (even when dosing in the morning and taking benzos), the very high body temp (not the nice type),
general head fuckiness, pretty bad constipation (contributed with codiene also), and just generally feeling like crap when it wears off.

This normally happens eventually and after abstaining for abit, I can enjoy the effects again but never like I initially used too.

A break is definitely in order, a taper anyway as I feel so crap coming off it cold turkey.
The high is not what it used to be but always end up dosing for the SRRI/SNRI effects and not too feel shite. I even choose to dose tram over better chems like MDMA etc, partially because of trams interactions with alot of drugs but mainly out of habit and avoiding WD.

150mg used to have me nodding out, feeling like a king now somehow im up to 400mg's a day with a new source to do so. I won't take less than 400mg's either as it feels like im missing out.

I normally take benzos too, sometimes it synergises well and reduces agitation etc but othertimes i feel it takes away the good elements of trams effects.

I've started work and already a work mate said infrount of everyone "you're fucking wrecked arn't you!"....not good.

Also like shambles, I find tram pretty potent, with comparisons also.

Tram also makes me chat shit ;)
 
lazydullard said:
I mean, if you gotta be addicted to something, tramadol is a good choice, yeah?
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Cheap and easy to acquire? Yup. Good to be addicted to? Hell no. Leaving aside how shit addiction to anything is, being addicted to a drug with both opioid and anti-depressant effects is not too great. Why have only one set of shitty withdrawals to deal with when you can have two instead? And, as if it's not tempting enough already, how about throwing in a dash of seizure risk plus the fact that you can't use most actual fun drugs when you're on tram cos it interacts so viciously with fuckin' everything? :!

I can think of better addictions... can think of worse too, admittedly 8)
 
Lazygit: I've been where you are. An idea is to use extended release caps, if you're not already using those. There will be no rush at all, but you won't feel depressed, and tapering will be a whole lot easier.
 
lazygit said:
Im getting alot of the shitty effects from long term high dose tram use... not sleeping (even when dosing in the morning and taking benzos), the very high body temp (not the nice type),
general head fuckiness, pretty bad constipation (contributed with codiene also), and just generally feeling like crap when it wears off.

This normally happens eventually and after abstaining for abit, I can enjoy the effects again but never like I initially used too.

A break is definitely in order, a taper anyway as I feel so crap coming off it cold turkey.
The high is not what it used to be but always end up dosing for the SRRI/SNRI effects and not too feel shite. I even choose to dose tram over better chems like MDMA etc, partially because of trams interactions with alot of drugs but mainly out of habit and avoiding WD.

150mg used to have me nodding out, feeling like a king now somehow im up to 400mg's a day with a new source to do so. I won't take less than 400mg's either as it feels like im missing out.

I normally take benzos too, sometimes it synergises well and reduces agitation etc but othertimes i feel it takes away the good elements of trams effects.



I've started work and already a work mate said infrount of everyone "you're fucking wrecked arn't you!"....not good.

Also like shambles, I find tram pretty potent, with comparisons also.

Tram also makes me chat shit ;)
Click to expand...



Be glad you are not at my level.........yet. Yesterday I took a total of 1800 mg's, 36 pills @ 50mg each. I am going to begin a taper though as this addiction is costing WAY too much each month. But I do get the feelings I got at first, just not as intense.
 
Wow, thats higher than even I was crazy enough to take. Although I'd take 1g in one dose. fucked up as shit and throw up. Feels bad man. I do NOT recommend it
 
For once I'm pleased to have the smallest dick in a thread - I've not yet let my tolerance go up past around 300mg.Have gone up to 400mg very occasionally but always take a tolerance break when it gets that high. Luckily I have plenty of replacements while it's on time out :D
 
I posted before I was finished as I wanted to add that in no way am I bragging about being able to take that amount. I am playing a very dangerous game, and just because I have'nt had a seizure yet, dose not mean I will not in the future. Hence the desire to lower my dose to 1000mg first, and then down to the maximum of 400mg a day.
 
Sounds like a plan to me. A bloody difficult plan that will take some considerable time to see come to fruition too. But with a pretty damn sweet outcome to look forward to. I know that tolerance breaks at 300-odd mg are bad enough - wouldn't like to think how much of a headfuck coming off five times as much was. Good luck and thanks for adding the addendum :)
 
I've been using it for 3 years. I run through my script fast and then wait it out. I spend at least 2 weeks a month not using Tramadol. Right now I'm getting close to the end of my script with a 300mg tolerance. But now I also share my script so it goes faster.
 
Shambles said:
For once I'm pleased to have the smallest dick in a thread - I've not yet let my tolerance go up past around 300mg.Have gone up to 400mg very occasionally but always take a tolerance break when it gets that high. Luckily I have plenty of replacements while it's on time out :D
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ha! my dick is much smaller! I've not gone above 150mg (but I do combine with 15mg hydro plugged).
 
Btw, when I said I took 1800 mg's yesterday, it was not a one dose deal. It was in 3 doses, spaced at 6 hours between the first and second, with a 700 mg dose on the first and a 600 mg dose on the second, approx. 7:00AM, and 1:00PM, and then the third dose of 500 mg at 7:00PM, so six hours later. I still sleep really well, and the only thint I mix with the tramadol is 800 mg of Ibuprofen four times a day. So far today a single dose of 700 mg at 12 noon, and I will probanly take another 600 mg's around 7PM tonight, for a total dose of 1300 mg's.
 
As I said before, I think it's great that we can discuss these things openly. I truly believe that the outcome of a real discussion will be much more beneficial.
 
PT, I get sleepy some, not all the time though. I usually go to bed at 10:00PM anyway as I have to be up at 6:15 to get ready to go to school, can you believe I am a middle school Health teacher and have been for 26 years, and I let myself get addicted to this shit! Anyway, sometimes I get home after school, lay down on the couch for a minute, then wake up 3 hours later. It is due to the tramadol I'm sure. At night I could stay awake until the wee hours if I so desired, but when I do go to bed I knock out like a log and sleep soundly. Don't know why the afternoon naps happen so infrequently, because the amount of tramadol I take daily is unchanged.
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