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Any Propositions for Exciting, New, Novel Benzos or Analogs??

D

daddysgone

Bluelighter
Joined
Oct 22, 2007
Messages
1,114
I hope I dont ruffle too many feathers with this one. I certainly am of the mind that opioid RC will lead to devastation and quite frankly, death. But, I dont really have the same reservations regarding benzos, if for no other reason then that they are already so widely available, and have a pretty stellar safety profile, provided they arent mixed with other CNS depressants.

Anyhow, since the analog act only applies to Schedule I and II drugs, and benzos fall outside of this scheduling, unless Im mistaken, any benzo or analog, unless specifically mentioned and controlled in the US, would be considered perfectly legal.

I know that phenazepam has popped up recently as just such a benzo that is perfectly legal due to its not being explicitly included in the list of scheduled benzos. Unfortunately, it seems as though phenaz is a dirty little bastard, and not something I really want to toy with.

But certainly, there must be infinite possibilities to to some minor tinkering and altercations to things like alprazolam and others, which would retain their overall character, but be chemically different, and thus legal. I really am surprised about how little is being done with this class of drugs-it just seems like the perfect opportunity. An entire class of drugs in which we are free to make minor adjustments and end up with a legal benzo.

What is the consensus here on this matter?-DG
 
Here in Italy we have we marketed Delorazepam for many years and doesn't seem to be available anywhere else. It is almost identical to lorazepam (in fact its active metabolite is lorazepam) but with a much higher elimination half-life (60-140) and has a pontecy of 1mg=10mg diazepam.

I stole a few vials from my grandpa once, I liked it, it's pretty sedating but it doesnt knock you out like other benzos.
 
Something else i tried is zolazepam (a peculiar looking benzo) which is very hard to find since its a veterinary drug normally sold in combination with the NMDA antagonist Tiletamine and available in very few countries.
I got it from the vet as Zoletil (an injectable solution of Zolazepam + Tiletamine) so i cant tell exactly 'how it was' per se but i can tell you one thing for sure: Boy was I high!

There is very little info about it on wikipedia:
http://en.wikipedia.org/wiki/Zolazepam
 
Thanks for the replies guys. First off, do you know if any of the three mentioned, Dolarazepam, zolazepam or premazepam, are unscheduled in the US.
If they are just rare, exotic benzos but are specifically scheduled in the US, then these are not the things Im looking for.

Im essentially interested in 2 things (one more then the other). I will list then im increasing order of interest.

1-Benzos which already exist and are available to other parts of the world, but have not been specifically scheduled in the US. Phenazepam is a good example of this (a good example for my criteria, but a pretty shitty example of a benzo). Again, because the analog act only covers schedule I and II drugs in the US, and benzos are not schedule I or II, any benzo which exists, which is not specifically scheduled, would be considered legal in the US, and one not fear the analog act biting them in the ass.

2-What I am more interested in, would be the possibility of tweaking some benzos which are scheduled (something like alprazolam), in such a way, that its effects/potency arent really altered, but the simple act of making an even minor change the molecule would technically result in the creation of a new molecule. This new molecule (despite having nearly identical effects/potency) would not be specifically scheduled (since it was just invented), and due to the scheduling of benzos, the analog act would not be able to be applied.

So basically, it seems that one could take their benzo of choice, make pointless alteration to it that would not alter its function, simply so they can now synth (or have synthed) a benzo that would be 100% legal.

Am I missing something? Why has this not been exploited?-DG
 
Hmm basically ur looking for a designer benzo or an existing benz which is unscheduled in the US. Someone here sould have a link to the latest schedule of controlled substances but i honestly dont know where to look for.
Maybe you could find em on some DEA or FDA website...
 
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Thanks for the reply. However, I think you meant to say that benzos are Schedule IV....not VI.

But yea, since the analog act only applies to schedule I and II, all one needs to do is find a benzo which is not specifically scheduled, and they are essentially in the clear. I know the US government LOVES to try to apply the analog act to everything, but the analog act CLEARLY states that it can only be applied to schedule I and II drugs. So while, any benzo you may find would certainly be an analog from a chemical point of view, the law does not allow for the analog act to be applied to things like benzos which are schedule IV.

EDIT
I know this is off topic, and Im sure has been discussed a million times, but how can those in charge of creating the schedule list even BEGIN to justify some of the scheduling choices they;ve made. I mean....the marijuana scheduling says it all. According to the the webpage which explains the process by which drugs are placed in various schedules, fora drug to go into schedule I, the strictest schedule which is comprised of drugs which are illegal in all cases and not used in medicine.

(A) The drug or other substance has a high potential for abuse.

(B) The drug or other substance has no currently accepted medical use in treatment in the United States.

(C) There is a lack of accepted safety for use of the drug or other substance under medical supervision.

Marijuana is placed in schedule I!!!! How can they, with a straight face, argue that marijuana has a high potential for abuse (esp when compared to something like oxycontin or amphetamines which are in a LOWER schedule). And to say marijuana has not accepted medical use.....just amazing. I dont even smoke pot, but that just boils my blood
 
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Now, that said. Asking Bluelight to help you with making new anaogues of benzos does in fact go again the: Drug Synthesis Rule.

It is allowed though to speculate on 'hypothetical drugs'. If you find one that catches your attention enought to trying a synth then dont ask 'the how to' on Bluelight.

Understand this or the thread WILL be closed.

- Ciao

PS: Have a i done a good job oh mighty Mods? i expect some peting :D
 
I was by no means asking for help on how to synth. I was speculating in very general terms about what could be done legally with a schedule IV substance. I dont believe I violated any rules at all, but if I did, I apologize and will remove anything the mods would like me to.
 
You're asking how to take a schedule IV drug to make an unscheduled drug? Hugely stupid. What's the point? If you're going through a scheduled drug to get to a nonscheduled drug, you aren't saving yourself from prosecution.

Besides, you can have any chinese custom synth place make you as much as you want (talking them into making you as little as you want is much more difficult) and if you find the right people, they'll do it competently and quickly.

Why benzos though? Benzos themselves are generally uninteresting and very unselective. Why not look at the unscheduled families with subtype selectivity? Put in enough work, and you should be able to find a benzo with the exact properties you want.

The benzodiazepine prodrugs are super interesting though.

personally, I want a slightly modified carisoprodol analogue.
 
Hammilton said:
...personally, I want a slightly modified carisoprodol analogue.
Click to expand...

Why? I was under the impression that soma wasn't scheduled in most states, and the ones where it is it's CV?


And Premazepam is not scheduled. It is supposedly alot better of a high than phenazepam, too.
 
Hammilton said:
You're asking how to take a schedule IV drug to make an unscheduled drug? Hugely stupid. What's the point? If you're going through a scheduled drug to get to a nonscheduled drug, you aren't saving yourself from prosecution.

Besides, you can have any chinese custom synth place make you as much as you want (talking them into making you as little as you want is much more difficult) and if you find the right people, they'll do it competently and quickly.

Why benzos though? Benzos themselves are generally uninteresting and very unselective. Why not look at the unscheduled families with subtype selectivity? Put in enough work, and you should be able to find a benzo with the exact properties you want.

The benzodiazepine prodrugs are super interesting though.



personally, I want a slightly modified carisoprodol analogue.
Click to expand...

Hammilton I think u misunderstood.
I do not wish to start with an existing schedule IV benzo, and alter it to something else. What Im asking about is precisely what you suggested-the possibility of having an interesting and novel benzo which is not specifically scheduled, synthed for me by a custom lab. By doing this, I would only be in possession of the unscheduled product, and would not be violating any laws.

I am intrigued though by a few things you said regarding benzo pro-drugs. You believe they have more recreational/pleasurable value then actual benzos? Care to elaborate? -DG
 
I wonder in rilmazafone if the metabolic pathway to the active metabolite involves direct iminization of the diphenylmethanone (as with a Schiff base). Can the body do this type of condensation does anyone know? There's a paper on this very subject but it's from 84 and I can't access it, and in the abstract it doesn't get into at what point the psychoactive metabolite is formed.

Anyway it's spun into the BZD conformation in the gut. If you shuffle the triazo ring nitrogens so you can have an alkyl substituent at its 1 position you'll end up with a structure similar to the beloved alprazolam and triazolam. Do this with an imidazo ring and you've got pro-midazolam. Or do we need that ugly carboxamide two positions over in order for the compound to be recognized as a substrate by the appropriate enzymes?
 
It's peanut butter jelly time! Let's just put a methyledioxy ring somewhere on those phenyls and start touching eachother!

XD

Though it would be fucking sweet to have a benzo with SSRI properties....
 
Also if we really have to 'come up' with a new benzo I would aim towards higher euphoric an anxiolitic properties rather that higher hypnotic potentials.
Hyper-hypnotic benzos already exist that are way too potent to be recreational, i've never tried Flunitrazepam nor am I willing to try it since I'm pretty sure it would put me right to sleep even if i have been a 1.5 years Clonazepam addict.
(God, it gives me shivers just thinking that I ended up injecting 25mg even twice a day, what was i thinking?)
 
/navarone/ said:
It's peanut butter jelly time! Let's just put a methyledioxy ring somewhere on those phenyls and start touching eachother!

XD

Though it would be fucking sweet to have a benzo with SSRI properties....
Click to expand...

Why in God's name would you want ANYTHING to have SSRI properties attached to it. I suppose there are some people out there that have found SSRI's to be helpful in treating their depression, but on the whole, I would argue that SSRI's represent one of the most over-hyped, failures of a class of drugs.
Drug companies spent hundreds of millions of dollars to convince doctors and patients that serotonin levels are the key to depression and that SSRI's are THE answer.
The sad part is that their efforts to convince us of this worked, despite the fact that their drugs didnt.

The only effect I (and almost everyone Ive spoken with) feel from SSRI's, is a total loss of libido.

In my view, the only good usage for SSRI's would be if they were forcibly administered to repeat sex offenders. If this were done, I assure you the rate of sex crimes would plummet.-DG
 
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