Tchort
Bluelight Crew
- Joined
- Mar 25, 2008
- Messages
- 2,392
The harm is not in giving your opinion based on experience. There is no problem with you telling someone they may be dosing too high because based on your experience etc etc. The problem is when this opinion gets taken too far and is touted as fact with blanket statements being made by multiple people reinforcing these incorrect statements. This gives the impression that the answer being given by multiple different people is correct based on how many people say it is true.
I already said what the harm is:
In the past I would post the following excerpt from the Suboxone prescribing guide as proof against this theory and set of ideas, because it states plainly that Buprenorphine has additional agonist effect in increasing doses at least up to 32mg based on the tests/studies done.
From the Suboxone prescribing insert:
Clinical Pharmacology
Subjective Effects:
Comparisons of buprenorphine with full agonists such as methadone and hydromorphone suggest that sublingual buprenorphine produces typical opioid agonist effects which are limited by a ceiling effect.
In non-dependent subjects, acute sublingual doses of SUBOXONE tablets produced opioid agonist effects, which reached a maximum between doses of 8 mg and 16mg of SUBUTEX. The effects of 16mg SUBOXONE were similar to those produced by 16mg SUBUTEX (buprenorphine alone).
Opioid agonist ceiling effects were also observed in a double-blind, parallel group, dose ranging comparison of single doses of buprenorphine sublingual solution (1, 2, 4, 8, 16, or 32 mg), placebo, and a full agonist control at various doses. The treatments were given in ascending dose order at intervals of at least one week to 16 opioid-experienced, non-dependent subjects. Both drugs produced typical opioid agonist effects. For all the measures for which the drugs produced an effect, buprenorphine produced a dose-related response but, in each case, there was a dose that produced no further effect. In contrast, the highest dose of the full agonist control always produced the greatest effects. Agonist objective rating scores remained elevated for the higher doses of buprenorphine (8-32 mg) longer than for the lower doses and did not return to baseline until 48 hours after drug administrations. The onset of effects appeared more rapidly with buprenorphine than with the full agonist control, with most doses nearing peak effect after 100 minutes for buprenorphine compared to 150 minutes for the full agonist control.
http://www.suboxone.com/pdfs/SuboxonePI.pdf
Another thread where this theory is spread as gospel to people with a question seeking answers:
http://www.bluelight.ru/vb/showthread.php?t=413346&highlight=suboxone+prescribing+insert
The entire purpose of this thread is to help do the job it was created for: propogate and advocate harm reduction philosophy. In my opinion, part of harm reduction is access to free and accurate information as well as subjective experience reports. Statements like, "there is no benefit to doses over 8mg on Bupe" and "24mg is a huge dose it is ridiculous you do not need that much" etc go against the science, the prescribing guide, the information given out by the company that makes and markets the Buprenorphine products, the inventors of the protocol for BMT, etc
A bigger harm than the chance of people following incorrect information which may lead to bigger consequences like OD or relapse, is that allowing one example of incorrect information to take root and spread on BL leads the door open for more inaccurate, unfounded or flat out untrue claims to be made and never disputed- which could lead to bigger individual consequences depending on the subject. Facts are facts, opinions are opinions. I want to keep it that way.
I already said what the harm is:
I am not advocating higher doses of Buprenorphine, I am advocating the facts. To make recommendations to people, that people often do take literally especially when more than one person gives the same advice, based on incorrect informations is highly irresponsible. Especially when harm-reduction is the goal. Relapse and continued use of narcotics is pretty widespread from self reports and reports from Bupe doctors- often because of how the BMT system is regulating and the lax policies surrounding its use in maintenance. People who try to stay abstinent may indeed need a dose increase instead of a dose reduction. When they take away from a site like this where they ask for advice that they need to lower their dose, they probably will: What happens to that person when the lower dose does no better or does worse for them than the original dose? Anyone want to take responsibility for giving bad advice when someone relapses or overdoses?
We don't know what happens to people who ask these questions unless they report back. Look how many people who posted here are dead in the BL shrine. We can't afford to pretend opinions are fact when people put trust, for right or wrong, in what we as a whole advise them.
In the past I would post the following excerpt from the Suboxone prescribing guide as proof against this theory and set of ideas, because it states plainly that Buprenorphine has additional agonist effect in increasing doses at least up to 32mg based on the tests/studies done.
From the Suboxone prescribing insert:
Clinical Pharmacology
Subjective Effects:
Comparisons of buprenorphine with full agonists such as methadone and hydromorphone suggest that sublingual buprenorphine produces typical opioid agonist effects which are limited by a ceiling effect.
In non-dependent subjects, acute sublingual doses of SUBOXONE tablets produced opioid agonist effects, which reached a maximum between doses of 8 mg and 16mg of SUBUTEX. The effects of 16mg SUBOXONE were similar to those produced by 16mg SUBUTEX (buprenorphine alone).
Opioid agonist ceiling effects were also observed in a double-blind, parallel group, dose ranging comparison of single doses of buprenorphine sublingual solution (1, 2, 4, 8, 16, or 32 mg), placebo, and a full agonist control at various doses. The treatments were given in ascending dose order at intervals of at least one week to 16 opioid-experienced, non-dependent subjects. Both drugs produced typical opioid agonist effects. For all the measures for which the drugs produced an effect, buprenorphine produced a dose-related response but, in each case, there was a dose that produced no further effect. In contrast, the highest dose of the full agonist control always produced the greatest effects. Agonist objective rating scores remained elevated for the higher doses of buprenorphine (8-32 mg) longer than for the lower doses and did not return to baseline until 48 hours after drug administrations. The onset of effects appeared more rapidly with buprenorphine than with the full agonist control, with most doses nearing peak effect after 100 minutes for buprenorphine compared to 150 minutes for the full agonist control.
http://www.suboxone.com/pdfs/SuboxonePI.pdf
Another thread where this theory is spread as gospel to people with a question seeking answers:
http://www.bluelight.ru/vb/showthread.php?t=413346&highlight=suboxone+prescribing+insert
The entire purpose of this thread is to help do the job it was created for: propogate and advocate harm reduction philosophy. In my opinion, part of harm reduction is access to free and accurate information as well as subjective experience reports. Statements like, "there is no benefit to doses over 8mg on Bupe" and "24mg is a huge dose it is ridiculous you do not need that much" etc go against the science, the prescribing guide, the information given out by the company that makes and markets the Buprenorphine products, the inventors of the protocol for BMT, etc
A bigger harm than the chance of people following incorrect information which may lead to bigger consequences like OD or relapse, is that allowing one example of incorrect information to take root and spread on BL leads the door open for more inaccurate, unfounded or flat out untrue claims to be made and never disputed- which could lead to bigger individual consequences depending on the subject. Facts are facts, opinions are opinions. I want to keep it that way.
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