• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Cheating the sandman

Since the OP decided to ignore four people's advice, I suggest no one answers him anymore. Always remember that the main purpose of BL is harm-reduction, and this thread most certainly does not qualify as such.
 
yeh you need dreams. i feel that drug use and sleep deprivation both kill your dreams which make you suffer horribly.

but if you want to really be Mr. President Number #No.1/I of the republic of agdgdgwengo then its worth it to cut out a part of your brain in order to never sleep again. thne you can create an army of zombie soldiers like you to take over.

hope this helps.
 
If run-of-the-mill stimulants just don't do it for you, you could try delta-ACTX. This remarkable and not-too-often used compound opens your sodium ion channels en masse, and in one invigorating thrum after another, every axon in your nervous system becomes a gattling gun of action potentials, firing without mediation, causing epinephrine, acetylcholine and norepinephrine to virtually gush out of your ears. Let me know if this works for you.
 
Ugh, keep it to the newbie to uphold harm reduction 8(.

every axon in your nervous system becomes a gattling gun of action potentials
Click to expand...

That sounds like excitotoxicity to me.

Isn't that a spider toxin anyway?

Do you recommend reserpine for depression, too?
 
you mean versutoxin? Hehe

edit: Take a joke man. btw- how does reserpine fit into the analogy? It's way different, it blocks VMAT entirely so MA's can't get into the synapse... Unlike amphetamine which is taken up by VMAT2 which then causes a massive release.
 
Oh that was a joke? If so, I apologize. It just isn't clear enough.

I guess I didn't mean to for an accurate analogy. What came to mind is simply chatecholamine depletion...
 
OP on the off chance that you live in Sydney and have access to funnel spider venom, my last post was not intended to be heeded. I have to say, though, that if modafinil has not satisfied your need for preternatural wakefulness and you are not narcoleptic, you have a bigger problem than the insurmountability of sleep: you want to get high.

Jamshyd, a couple of things you told me a couple of weeks ago (about amps+benzos) have made me seriously question my motives for being on the meds I'm currently on, and I'm grateful.

Regarding this thread, I still think that occasional and minimal doses of ephedrine are not a bad idea if, for instance, one has to pull an all-nighter or work 3rd shift at a new job. The drug's unsavory side effects lower it's addictive potential. I prefer just mixing ground-up ephedra sinica stem into juice, because most post-ban US formulations of ephedrine go down my esophagus like they're really angry at me.
 
Too bad you don't have chronic insomnia. Sometimes I'm so lucky that sleep only robs me of a twelfth of my valuable time. I'm sure you would have loved the feeling of slowly going insane, and the constant exhaustion.

In all seriousness, it would be a good learning experience for you. Then you might understand why people like me appreciate every bit of sleep we're able to get.
 
seep said:
Jamshyd, a couple of things you told me a couple of weeks ago (about amps+benzos) have made me seriously question my motives for being on the meds I'm currently on, and I'm grateful.
Click to expand...
I am very happy to hear this! And again, sorry if I appeared harsh at all...
 
Jamshyd said:
Since the OP decided to ignore four people's advice, I suggest no one answers him anymore. Always remember that the main purpose of BL is harm-reduction, and this thread most certainly does not qualify as such.
Click to expand...

Hey now, where's all this coming from? I very deliberately worded my question to ask about the MAXIMUM HOURS of MENTAL CLARITY that someone could achieve on an INDEFINITE BASIS.

If the answer to that is "16, you need 8 hours of sleep or you go insane", then that's the answer I'm looking for.

But looking at the available information, it hardly seems to be the case. Buckminster fuller apparently took only 4 thirty-minute naps a day for two entire years, and he lived to the ripe old age of 88.

I'm attempting polyphasic sleep, and while I'm only on day 3, my experience so far has been rather intriguing. So far the big problem seems to be my inability to get to sleep in a reasonable amount of time once laying down.
 
DEAagent924440385 said:
...MAXIMUM HOURS of MENTAL CLARITY that someone could achieve on an INDEFINITE BASIS.
Click to expand...

The puerility of your comment about sleep stealing a 3rd of one's life was kind of hard to ignore. It's sort of like someone saying, "Ears make the human head 10% less aerodynamic."

Your question is an optimization problem with too many variables, some of which are not entirely observable. Even if one were able to tag and differentiate all the relevant transmitters/receptors/etc. involved in human cognition (the mechanism of which we don't even understand yet), all the computers in the world would need to work together for billions of years to coordinate, process and interpret all the data collected from an experimentally-meaningful sample size.

I'm attempting polyphasic sleep, and while I'm only on day 3, my experience so far has been rather intriguing. So far the big problem seems to be my inability to get to sleep in a reasonable amount of time once laying down.
Click to expand...

Consider asking, "What drugs can I take to counteract the insomnia I get from the drugs I take to counteract the somnolence I get from the drugs I take to counteract the insomnia I get from the drugs I take to . . . ?" I ask myself that every day.

Good luck man. Really. I'm about to take 2 mg alprazolam with 75 mg ranitidine so I can get to sleep and wake up at 4 am tomorrow morning and over the subsequent 12 hours take 20-60 mg Adderall and 200-400 mg DMAE and a gallon or two of coffee so I can cram and be acute for my 5 pm Calculus final because I've slept a whopping 7 hours and ingested obscene amounts of psychotropic substances since Sunday morning. I currently can't say for certain whether the lights are on or off in the room I'm seated in. But all this because it's finals week, not because I want to become a hyposomnic mutant. Tomorrow night, this semester is over and I return to my regular pursuit of filling as many female orifices as possible (I've found that sleep enhances my success rate).
 
seep said:
The puerility of your comment about sleep stealing a 3rd of one's life was kind of hard to ignore. It's sort of like someone saying, "Ears make the human head 10% less aerodynamic."
Click to expand...

If cutting my ears off would extend my effective lifespan by 20 years, I'd do it. If regarding time as an irreplaceable resource is puerile, I guess that's what I am.
 
^ You STILL don't get it, do you?

Fucking up your sleep cycles shortens your lifespan. Which part of that 1/3rd are you saving by destroying a 1/2??

But who am I kidding? There is no reasoning with amp. heads.

Get back to us when you're crying for help.
 
Well, buckminster fuller lived to the ripe old age of 88, but if an internet busybody says it's impossible, who am I to argue?

Most of the people who've tried polyphasic sleep say they gave up because of hostility from those around them. It sounded like an excuse, but I'm beginning to see where they're coming from. I feel like the spidery guy from that vernor vinge book.

What is an "amp. head"?
 
I've been trying polyphasic sleep for two months now, and I can't really get the hang of it. It seems very promising, but I just can't GET to sleep unless I'm really tired. I've never been one to nap.

I feel like my train of thought runs on this unstoppable flywheel and the only way to stop it is to let it run down of its own accord. But by that point, I've been awake much too long and so I have to sleep a regular amount.

Anybody have advice on how to get to sleep quickly, without compromising the ability to wake up again an hour or less later?
 
Ampakines:

New Scientist 05/14/2005 said:
....OMITTED THE PRELIMINARY RAMBLING SWILL THAT CHARACTERIZES ARTICLES IN SCIENTIFIC PERIODICALS...

Ampakines work by boosting the activity of glutamate, a key neurotransmitter that makes it easier to learn and encode memory. They change the rules about what it takes to create a memory, and how strong those memories can be, says Gary Lynch of the University of California at Irvine, who invented the drugs. "We all have the same computer," he says, "but we're running with different voltage levels." Ampakines up that "voltage".

The effects can be dramatic, as Julia Boyle at the University of Surrey, UK, and her colleagues have now shown. They tested an ampakine called CX717 on 16 healthy males aged between 18 and 45. The men were given either 100 milligrams, 300 mg or 1000 mg of the drug, or else a placebo. In repeated trials the volunteers cycled through the treatments so that their performance with different amounts of CX717 could be compared directly.

In each test session, the volunteers started with a full night's sleep and the following morning and evening were given a battery of tests. These assessed memory, attention, alertness, reaction time and problem solving. Then, at 11 pm, the volunteers swallowed their pills and stayed up through the night. At midnight, 1 am, 3 am, 5 am and 9 am, they were re-tested on some of the tasks. And at 4 am, cruelly, they were tucked into bed in a darkened room and told to stay awake. The researchers measured heart rate and brainwave activity to monitor how alert the subjects were and whether they fell asleep.

Even the lowest dose of CX717 significantly improved the sleep-deprived volunteers' wakefulness and cognitive performance. And the more ampakine they took, the more they improved and the longer the effect lasted. Roger Stoll, CEO of Cortex, the Irvine-based company in California that owns the drug, announced the trial results at an investors' conference on 4 May. While specifics were scant, he mentioned that in the dark room, for instance, most volunteers taking placebo dozed off within about 3 minutes, while some ampakine users stayed awake for the entire 15-minute test. And on a test of sustained attention, effects kicked in within an hour of consuming the drug, he revealed. Crucially, the subjects suffered none of the jitteriness that comes with caffeine or amphetamines. "It generates a state of cortical wakefulness without stimulation," says Lynch.

CX717 will have to undergo further clinical trials before gaining approval as a drug. Cortex is considering it as a possible treatment for narcolepsy, jet lag, attention deficit hyperactivity disorder, and Alzheimer's disease.

Meanwhile animal studies hint at even more impressive effects. Research on rhesus macaques, carried out for the US military by Sam Deadwyler at Wake Forest University School of Medicine in Winston-Salem, North Carolina, found that sleep-deprived monkeys on CX717 actually performed better on reaction time and accuracy tests than when they were well rested. And non-sleep-deprived monkeys given the drug did better still.
Click to expand...





hammilton said:
btw- how does reserpine fit into the analogy? It's way different, it blocks VMAT entirely so MA's can't get into the synapse... Unlike amphetamine which is taken up by VMAT2 which then causes a massive release.
Click to expand...

Why does it need to "fit" into an analogy? Jamshyd's simply saying that, just as prescribing delta-ACTX to the OP for his problem of, uhhhh, sleeping is hopelessly stupid and counterproductive, prescribing reserpine to a depressed individual would be. It was a jab at his understanding of pharmacology that had seemingly - but of course not really - prompted him to recommend a drug that would produce only profound harm. Jamshyd wasn't intimating a belief that delta-ACTX and reserpine were antithetical or similar to one another in terms of mode of action.
 
Last edited:
Haha, how much of an idiot are you, while we need only a couple of our 8 hours for mental health we need to the full 8 to replenish ourselves physically, 9 is a good number, and always try to sleep at the same time, this makes it easier for your body to use the time effectively,

now if only I listened to my own advice.....
 
Low doses of Kratom, 2-5 g's. In particular a thai strain or malay. Natural and effective. Taken at night should provide one with insomnia. %)
 
You must log in or register to reply here.
Top