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beta ketone version of IAP

^ And there we have it in one. The hydrochloride (or other) salt would be OK, it's just the difficulty in getting to that point...

Anyway, why go for the ketone version of IAP - some thinking that it might up it's dopaminergic activity while reducing it's serotonogic effect (a la MDMA-methylone comparison?)
 
Why bk's,maybe why they're shorter active,IAP being a bit a too long goer?
 
Has the n-methyl variant of IAP been tasted ( Indanylmethamphetamine )?
As a secondary amine, I guess it would form a reasonably stable beta ketone - 3,4-indanylmethcathinone...
 
MokumChemist said:
...3,4-indanylmethcathinone...
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There is no such thing as 3,4-indanylmethcathinone, since it would mean that an indanyl group is attached to methcathinone. The correct name is 1-(2,3-dihydro-1H-inden-5-yl)-2-(methylamino)propan-1-one or 1-(indan-5-yl)-2-(methylamino)propan-1-one.
 
Its because Beta-Ketones are what's in now. Liek, theriousley! Get with the tiemth!!1
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Haha, methinks it might be a legality thing :).

Beta ketones aren't that predictable are they?

Generally there seems to be some sort of pattern concerning DA and SE effects, but the relationship between B1 and MBDB breaks the family up a bit.

What other groups can you chuck on the beta carbon? I imagine you have a fairly limited alkyl chain before you lose any activity.
^ And there we have it in one. The hydrochloride (or other) salt would be OK, it's just the difficulty in getting to that point...

Anyway, why go for the ketone version of IAP - some thinking that it might up it's dopaminergic activity while reducing it's serotonogic effect (a la MDMA-methylone comparison?)
Click to expand...

There are ways around this in the synth, Shulgin made some stable BK 2c's.

In my humble subjective experience, most beta ketones seem less serotonergenic than their none BK cousins.
 
IlostaMadge said:
In my humble subjective experience, most beta ketones seem less serotonergenic than their none BK cousins.
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Yes, however most users seems to push the dosage until they reach similar subjective levels as the non-BK's.
 
As IAP is almost a derivative of MDA,

and 5-Methyl-MDA is 6x as potent seretonin
releaser than MDA would there be any scientific
basis to assume the same might apply to IAP.

Would a beta ketone of IAP be similar in effect
to the beta ketone of MDA
 
Interesting doesn't methylone have a higher dopamine push compared to MDMA, whilst IAP have a more serotonergic push. [I used the word "push" as can't remember if the research was looking purely at re-uptake inhibition?]

Anyway the point:

could bk_(n-methyl)-IAP be a happy medium (ala MDMA) ?


haha if only things were that logical :D , although if bk-IAP was anything similar in 5-ht potency possibly increasing the alpha carbon chain is always an option for increase dopamine re-uptake potency.

[EDIT sorry just seen F&B has made the point already]
 
As IAP is almost a derivative of MDA,

and 5-Methyl-MDA is 6x as potent seretonin
releaser than MDA would there be any scientific
basis to assume the same might apply to IAP.

Would a beta ketone of IAP be similar in effect
to the beta ketone of MDA
Click to expand...


However does this translate into a more euphoric or desirable compound, or is it just "different"?
 
Reminisant B said:
Interesting doesn't methylone have a higher dopamine push compared to MDMA, whilst IAP have a more serotonergic push. [I used the word "push" as can't remember if the research was looking purely at re-uptake inhibition?]

Anyway the point:

could bk_(n-methyl)-IAP be a happy medium (ala MDMA) ?


haha if only things were that logical :D , although if bk-IAP was anything similar in 5-ht potency possibly increasing the alpha carbon chain is always an option for increase dopamine re-uptake potency.

[EDIT sorry just seen F&B has made the point already]
Click to expand...


It would do away with the need to co-administer a dopaminergic drug along with IAP to get full on MDA effects (if the beta-keto effect applied acrioss the board). Still want to hear of someone trying the IAP analogue of MMDA as I have a feeling in my water that it'd have a very similar effects profile etc
 
The very interesting thing about IAP is that, according to wikipedia, it's a non-neurotoxic stimulant with effects comparable to MDA.

I guess that by adding a methyl group to the amine the effects could match those of MDMA and still keep its non-neurotoxic effects. Though this is just a feeling...

Instead of a beta keto version of IAP I'm fantasizing on a more 'psychedelic' analogue like 3,6-dimethoxy-IAP (maybe with a N-methyl too). This molecule would be almost identical to Ganesha (PiHKAL) but it might loose the advantage of being non-neurotoxic.

http://en.wikipedia.org/wiki/Ganesha_(psychedelic)
 
3,6-dimethoxy-IAP
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This molecule would be almost identical to Ganesha
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No, it would be exactly identical to 3C-G-3, aka. G-3. Check in pihkal.

Also if you add an N-methyl there, any psychedelic activity will very probably be nullified. Secondary amines don't work well as psychedelics. See N-methyl-DOM in pihkal.
 
There's plenty of information about it in pihkal.

QUALITATIVE COMMENTS: (with 12 mg) There was a warmth, a mellowness, as things developed. No body disturbance at all, but then there were no visuals either which, for me on this particular occasion, was disappointing. The day was consumed in reading, and I identified completely with the character of my fictional hero. It was a different form of fantasy. I think I prefer music as a structural basis for fantasy.

(with 18 mg) I am at a plus three, but I am not at all sure of why it is a plus three. With my eyes closed, there are puffy clouds, but no drama at all. Music was not exciting. There could well have been easy eroticism, but there was no push in that direction. No great amount of appetite. Not much of anything, and still a plus three. Simply lying still and surveying the body rather than the visual scene gave some suggestions of neurological sensitivity, but with getting up and moving about and doing things, all was fine. The next morning I was perhaps moving a bit more slowly than usual. I am not sure that there would be reward in going higher.
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