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Aphrodisiacs of the Future

That was an example of how thouroughly it killed my desire in the end (before that when one of us was ready, the other was clamy and anxious & vice versa). We both had some really bizzarre animal spirit sort of dreams afterwards though...


Maggie Thatcher in leather fetish gear in a legs open pose 8o :! What a thought (sorry anybody who ws earing when they read that)
 
For what it's worth, combating decreased libido is one of the major drives for improvements on SSRIs as novel antidepressant agents. A big section is devoted to this both in MJ Millans recent review: http://dx.doi.org/10.1016/j.pharmthera.2005.11.006 and a further perverse justification for incorporation of a dopaminergic tone both in combination therapy: http://dx.doi.org/10.1016/j.biopsych.2005.06.027 and as conflation into a standard SNRI: http://www.ingentaconnect.com/content/ben/cnsnddt/2007/00000006/00000002/art00006.

Also, after reading PIHKAL, DOB was purveyed as some sort of intensely pro-sexual agent. I think that's hype, although one knows from experience that stimulants in general, for example coffee, tend to increase libido. In terms of tryptamines, ive read that the compound 5-MeO-DIPT possesses prosexual like qualities: http://www.erowid.org/library/books_online/tihkal/tihkal37.shtml
 
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PT-141 (know also known as bremelanotide) should be out at the end of 2008.
if maker Palatin's data are in order. It is a new class of drugs called alpha melanocortin agonists and it is supposed to work in both men and women, and unlike sildenafil (Viagra), it causes desire as well as ability.

I am sure a lot of people are looking forward to this one. I have not been able to get a hold of any but I am working on it.

MobiusDick
 
A Phase III clinical trial was scheduled to begin in the first half of 2007, but was delayed until August 2007. On August 30th, Palatin announced that the FDA had expressed serious concerns regarding the benefit/risk ratio of bremelanotide with regards to the side effect of increased blood pressure. The FDA also stated that they would consider alternate uses for bremelanotide, including as a treatment for individuals who do not respond to more established ED treatments.
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http://en.wikipedia.org/wiki/Bremelanotide

I've heard anecdotally melanotan II is better, has less side effects, and also has the benefit of giving you a tan.
 
yes MTII is better for some for libido

you will not get any melanotrophic activity unless used with some frequency and i am not sure if there is attenuation then on the libidogenic effect (i believe so)

noatbly also some do not tan, but will get negative effects such as darkening and heighteneing of moles/freckles
 
Your post just reminded me of this...

Has anyone read The Atomic Boy Scout (something along those lines) about a boy scout in Michigan, maybe a genius, I dunno- who fell in love with radioactivity and built his own mini-reactor out of cesium or radium (thorium?) from Coleman Lantern hood-things (you know what I'm talking about, right?)- and how eventually a government agency raids his house and cordons off the neighborhood.

He was into tan-inducing chemicals
 
I've found yohimbine to be strongly stimulating but absolutely no effect on performance or desire. At levels where you can feel it definitely not a particularly pleasant sensation.
 
there is a small percentage of user who respond very well to yohimbine but for most it is an ugly compound to play with and can be downright miserable
 
Bump

I am really struggling with a totally killed labido and anorgasmia from nardil. Any thoughts on what could help? It is a life saving drug for me after trying everything else, but its destroying my relationship with my girlfriend. Any help or advice would be hugely appreciated
 
nuke said:
Yes, it's interesting to note that orexin and MCR-3 and MCR-4 isoform deviations can confer an increased risk of obesity too -- like dopamine, it seems that pleasure-related compounds are the same for food as they are for sex.
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Is that why people get fat after they get married (ie getting regular sex, well at least for some lol)=D
 
I'm probably going to get flamed for saying this and I wouldn't really class these compounds as 'aphrodisiacs of the future', but I would have to say that androgenic steroids work quite nicely ;)

If you were in a situation where you could only see your girlfriend once every few months, you could use testosterone propionate, a short acting ester to use for the short period of time that you see her. The increase it caused in my sex drive was absolutely phenominal. I was only satisfied after three orgasms and got rock hard erections due to being rediculously horny.
 
I get almost no effects from yohimbe that is supposed to contain 20mg yohimbine if u consume 3 capsules.

I dont really think it is a sexual stimulant. Anyway unless people are impotent I dont even see the need for these meds. I personally have never tried viagra.

I tried augmenting Cymbalta with the yohimbe. The results we not successful.
 
Yohimbine is an intense aphrodesiac and nearly give me priapism every time.
 
I don't think there is any proof that yohimbine is an aphrodisiac (I may be wrong, but I think this evidence is only anecdotal as with may drug claims these days). It is only an impotence treatment, and a poor one at that so I have been told (lots of unnecessary side effects).
 
If you ask me Cannabis is a pretty good aphrodisiac by itself, I always get really horny if I just start to think about anything sexual. I find that if you do it during your high it kinda kills it though, so I do it when its about to wear off, but the aphrodisiac effect remains.
 
Yohimbine is a god-damned load of horse shit. I've read a number of studies demonstrating that [agonist] adrenergics produce a large release of prolactin and that sympatholytics have a very pronounced prolactin-lowering effect. In my own experiences I accidentally verified this without expecting the result at all; I have found that unless I co-administer my stimulants with sympatholytics they have invariably a negative impact on my libido. Antagonists (and I use the word very loosely) of beta receptors like labetalol pindolol clonidine and even metoprolol have the most positive impact whereas alpha blockers like doxazosin seem to do fuck-all.

So, I play the god-damned annoying balancing game of taking a stimulant and finding myself too anxious or bereft of libido, taking a sympatholytic and finding myself too tired or confused, taking a little more of the stimulant to wake myself up and becoming too anxious again etc... I wish recreational use of drugs weren't so frustrating; it's hard and costly enough just obtaining the drugs let alone obtaining and using correctly the right apotropaic and palliative ancillaries.

Of course that's just me. My prolactin levels due to chronic and unyielding stress (I truly can't remember the last time I breathed easy) are probably absurdly high.
 
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Artificial Emotion said:
I'm probably going to get flamed for saying this and I wouldn't really class these compounds as 'aphrodisiacs of the future', but I would have to say that androgenic steroids work quite nicely ;)

If you were in a situation where you could only see your girlfriend once every few months, you could use testosterone propionate, a short acting ester to use for the short period of time that you see her. The increase it caused in my sex drive was absolutely phenominal. I was only satisfied after three orgasms and got rock hard erections due to being rediculously horny.
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Just as a caveat to anyone reading this and thinking about acting on this advice: there are some individuals for whom testosterone has no such effect no matter how long it's taken. I fall into that category. I wasn't able to get anything out of testosterone except in nearly fatal doses that made me almost completely psychotic and delirious. In fact, it seemed to decrease libido usually; when I was lucky, it did nothing at all. I assumed that this was due to the action of aromatase, so I took an aromatase inhibitor and still nothing. In the overdose situations, I couldn't touch my penis without orgasming instantly, so all in all it's pretty useless for me.
 
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