• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Lysergamides LSD prodrugs and potency

Axemancometh

Bluelighter
Joined
Mar 12, 2026
Messages
62
Location
Canada
Anyone who knows a thing or two about acid knows that there are also countless RC analogues or 'pro-drugs' for good old 25. What I am referring to here are the 1-x-LSD variants, and not ETH-LAD, AL-LAD, or anything else.

I understand that these LSD 'pro-drugs' are pretty much indistinguishable from LSD-25, unless you want to delude yourself into thinking they have unique properties; (I would understand a slower come up due to hydrolysis) what I am asking is if they are technically less potent by weight than LSD-25 - because If they are really a 'pro-drug', then the added groups (the propionyl, valeryl, etc.) would have an added weight to the molecule - meaning that their breakdown would result in a lighter version of the final product? If so, could you scientificlly tell exactly how much weaker?

Help me understand.

Though I suppose the only way to know for sure would be to do a true blind test with what is confirmed to be 100ugs of LSD-25 with 100ugs of an LSD prodrug - but then again there will always be issues with set and setting and the subjects involved.

Damn you acid with your enigmatic nature.
 
ime some of the analogues have pretty different body highs, and there actually such thing as clean V.S. dirty LSD25 depending on how it's crystalized from what i read. i really know nothing about it scientifically, but i've heard people say that levels of something in the acid will make needle point or whatever have a different high than fluff and what not. i believe it's just the body high. i've had some street acid actually make me feel kind of shitty and some where i felt great. i would guess it was the type of LSD if what i'm saying is true, but i'm not sure. i'm pretty sure the analogues are different though.

i don't think what a person takes will really change the visuals. i believe that's all psychological. i really don't know if i would be able to tell the difference between LSD25 batches myself, but i believe i can tell the difference between eth-lad and ald-52 pretty easy. the eth-lad is more stimulating than even the 1p-lsd and i kind of feel like a tingly burning sensation from eth-lad. ald-52 isn't really stimulating, and i would be mistaken to say it's a downer feel, but when i say it's not stimulating, there is a weird feel different than the others..


sorry if this isn't the point of your thread. i would think you are wrong saying i'm deluding myself thinking they are different though.. i wouldn't want any one to take a dose of any of the analogues and be surprised the body high feels kind of different. maybe some people don't notice the difference. i've done several hundreds of doses of different analogues from those canadian vendors.



lots of google haters, but it usually picks up stuff people have said on the net. i searched "are lsd analogues said to have different body highs than lsd25?" and got "Yes, LSD analogues (lysergamides) are frequently reported by users to have different body highs, intensities, and physical sensations compared to LSD-25. While many popular 1-substituted analogues are thought to act as prodrugs—meaning the body metabolizes them into LSD-25—the user experience often varies in terms of come-up speed, duration, "body load" (physical tension/nausea), and overall "pleasurable high""


would be interested if people think of this. i know i hear a lot of people saying they are the same. it's actually the majority on the net now a days. people in the early 2000's on a site i was on liked eth-lad and said the analogues were different.
 
Last edited:
You can absolutely tell the difference in LSD25 it is conceived as a sacrament for self discovery and spiritual journeys, LSD25 presented it enhancing promise, a portal to access higher dimensions of consciousness, transcending social feathers. It was this promise that urged individuals to critically appraise and challenge social structures, instigating a paradigm shift towards individuals and the collective consciousness expansion.
 
Add the molecular weight of the 1-substitution to the molecular weight of LSD to get the new molecular weight of the prodrug, then you can say (these numbers are just for example) something like "Well I added the number up to 150 but LSD's original weight is 100 so I know that for every 3 micrograms of prodrug I will have 2 micrograms of LSD".

Just an example of how to calculate that, not actual numbers there obviously.
 
Anyone who knows a thing or two about acid knows that there are also countless RC analogues or 'pro-drugs' for good old 25. What I am referring to here are the 1-x-LSD variants, and not ETH-LAD, AL-LAD, or anything else.

I understand that these LSD 'pro-drugs' are pretty much indistinguishable from LSD-25, unless you want to delude yourself into thinking they have unique properties; (I would understand a slower come up due to hydrolysis) what I am asking is if they are technically less potent by weight than LSD-25 - because If they are really a 'pro-drug', then the added groups (the propionyl, valeryl, etc.) would have an added weight to the molecule - meaning that their breakdown would result in a lighter version of the final product? If so, could you scientificlly tell exactly how much weaker?

Help me understand.

Though I suppose the only way to know for sure would be to do a true blind test with what is confirmed to be 100ugs of LSD-25 with 100ugs of an LSD prodrug - but then again there will always be issues with set and setting and the subjects involved.

Damn you acid with your enigmatic nature.
 
LSD is an organic/synthetic drug much more stable and much more soul the visuals I get from LSD25 have a higher dimensional construction You can absolutely tell the difference in LSD25 it is conceived as a sacrament for self discovery and spiritual journeys, LSD25 presented it enhancing promise, a portal to access higher dimensions of consciousness, transcending social feathers. It was this promise that urged individuals to critically appraise and challenge social structures, instigating a paradigm shift towards individuals and the collective consciousness expansion you get your ass kicked if you come into my town with an analog version of LSD if you’re straight up with exactly what it is then you just got a verbal warning 25 was responsible for the summer of love it absolutely matters for shared hallucinations, & synchronicity psychedelics are not what we in my family fuck with we ARE BLESSED WITH real LSD…however the benzodiazepines and other miscellaneous sedatives and opioid RC’s Are good, that’s just my opinion. We make that real shit 25 you lie to yourself if you think those RC versions of acid are truly like the real thing tried taking 1000 micrograms of real LSD 25. There’s no mistaking who is king. I take 5000 at least 6-8 times per year and you can’t get to that level on RC’s the rest of the year 600 is my norm. I would like to be introduced to some more RC psychedelics but so far all of them just fall very short of mescaline & LSD. If you know your drugs 25 has a connection with an element that is truly blessed.
 
Last edited:
Anyone who knows a thing or two about acid knows that there are also countless RC analogues or 'pro-drugs' for good old 25. What I am referring to here are the 1-x-LSD variants, and not ETH-LAD, AL-LAD, or anything else.

I understand that these LSD 'pro-drugs' are pretty much indistinguishable from LSD-25, unless you want to delude yourself into thinking they have unique properties; (I would understand a slower come up due to hydrolysis) what I am asking is if they are technically less potent by weight than LSD-25 - because If they are really a 'pro-drug', then the added groups (the propionyl, valeryl, etc.) would have an added weight to the molecule - meaning that their breakdown would result in a lighter version of the final product? If so, could you scientificlly tell exactly how much weaker?

Help me understand.

Though I suppose the only way to know for sure would be to do a true blind test with what is confirmed to be 100ugs of LSD-25 with 100ugs of an LSD prodrug - but then again there will always be issues with set and setting and the subjects involved.

Damn you acid with your enigmatic nature.
LSD wasn’t moved and sold like the cartels move coke and heroin it was handled by a brotherhood truly doing the work of the gods The crystals must be handed by a brotherhood of people who truly believe they were doing the work of the gods or whatever you call creation, we believe that LSD Crystal has to be handled by the right people who are completely committed to the vibrant when we move crystal. There was always a feeling that we were protected. I can’t tell you how many times we should’ve gotten busted but didn’t so many times that it can’t be a coincidence why do I think we’re protected because the family does it for mankind not money we view LSD is the only hope for the world

OK, so you have some crystal and you need to get it on blotter it’s a pretty amazing feeling holding a jar in your hands that has 10 g of crystal in it. That’s 100,000 doses in the palm of your hand for dealing with laying will say we got 1 g of acid is always layered 1 g 10, 10 packs. A 10 pack is a 10 sheets 1 g equals 10,000 doses if you’re laying needle point your doses will be 95% pure if you’re laying Amber, your shit will be 70 µg because it’s 70% pure now you get a glass Pyrex pan to dip your 10 packs in your crystal is dissolved into 110 mL of Everclear program. The pure crystals dissolved instantly with a little stirring the not so pure take a little shaking champagne is damn near impossible to get dissolved evenly paper for white bladder standard watercolor paper #14 this paper is crucial or you’ll fuck it ok so you have your crystal dissolved and your paper cut and ready two schools when it comes to putting it on paper first dumped the solution in the pan and drip each 10 pack into it then lift it up and let’s say excess solution runoff into the pan. Second method is to put the 10 pack into the pan and squirt the solution on it with syringes. I’ve done both and preferred dipping them just because it’s quicker than the 10 packs are laid out to dry, which doesn’t take long since it’s alcohol evaporates like very quickly. If you did it right there will be very little residue left in the bottom of the pan. This residue is extremely potent, and it is either soaked up with a piece of paper called a mop head up or made into a potent liquid called wash the best Acid
While you are doing this, you are getting very very very high through the air as soon as you open the crystal. but you shouldn’t have any plans afterwards. It might be slightly different methods used while laying, but this is how to do it after the 10 packs of dried they are distributed and eaten up.

LSD is most definitely still around LSD 25 the clandestine laboratories have to operate for only four years to get four years worth of product something like that, though they usually produce enough to last even longer on a typical East Coast tour 100 to 150 g could easily be sold that’s 1,000,000 to 1,000,000 1/2 doses. This flooded these cities and the LSD trickle down to every nook and cranny of America then supporting the small communities

Common misconception about first purity and dosage so I wanted to make this shit clear because it seems that people are still a little confused about this. A lot of people say LSD is LSD and that is that that is not always true. There are different purities of crystal which have different effects you can have tabs from different sources and have a completely different experience without it being an RC however, LSD will always have no taste. Visual with morphine golden visuals other is more geometrical and usually has more body load and leaves me more drained the following days needlepoint very pure 95% white light flakes of crystal silver is good. It’s cleaned 85 to 90% light gray crystal was was around a lot in the 80s and 90s was really what they ate then there’s an amber crystal at 70% which I guess is decent. It’s buried from a light amber color to like it almost dark brown color. One batch called quadriceps amber with the color of light light honey was very good. Lots of people worked with this crystal, but I always would use silver instead since it was better in the same price lavender is 60 to 70% pure white purple to almost black colored crystal like Amber it varies batch to batch and then there’s TJ a tornado juice purity unknown. I’ve seen this shit in about four different colors, and it always scares me. No experience with it than the champagne that’s 50 to 60% pure and then there’s black crystals which are nasty.
1 g equals 1000 mg equals 1001 mg equals 100 hits 1 g equals 10 sheets or a book a sheet is 100 hits or 1 mg if you’re laying a 1 g of pure noodle point in your doses will be 95 MCG because you’re shit will be 70 MCG because it’s 70% pure THANK YOU,
DH TRISMEGISTUS don’t worry about the spelling errors
 
LSD wasn’t moved and sold like the cartels move coke and heroin it was handled by a brotherhood truly doing the work of the gods The crystals must be handed by a brotherhood of people who truly believe they were doing the work of the gods or whatever you call creation, we believe that LSD Crystal has to be handled by the right people who are completely committed to the vibrant when we move crystal. There was always a feeling that we were protected. I can’t tell you how many times we should’ve gotten busted but didn’t so many times that it can’t be a coincidence why do I think we’re protected because the family does it for mankind not money we view LSD is the only hope for the world

OK, so you have some crystal and you need to get it on blotter it’s a pretty amazing feeling holding a jar in your hands that has 10 g of crystal in it. That’s 100,000 doses in the palm of your hand for dealing with laying will say we got 1 g of acid is always layered 1 g 10, 10 packs. A 10 pack is a 10 sheets 1 g equals 10,000 doses if you’re laying needle point your doses will be 95% pure if you’re laying Amber, your shit will be 70 µg because it’s 70% pure now you get a glass Pyrex pan to dip your 10 packs in your crystal is dissolved into 110 mL of Everclear program. The pure crystals dissolved instantly with a little stirring the not so pure take a little shaking champagne is damn near impossible to get dissolved evenly paper for white bladder standard watercolor paper #14 this paper is crucial or you’ll fuck it ok so you have your crystal dissolved and your paper cut and ready two schools when it comes to putting it on paper first dumped the solution in the pan and drip each 10 pack into it then lift it up and let’s say excess solution runoff into the pan. Second method is to put the 10 pack into the pan and squirt the solution on it with syringes. I’ve done both and preferred dipping them just because it’s quicker than the 10 packs are laid out to dry, which doesn’t take long since it’s alcohol evaporates like very quickly. If you did it right there will be very little residue left in the bottom of the pan. This residue is extremely potent, and it is either soaked up with a piece of paper called a mop head up or made into a potent liquid called wash the best Acid
While you are doing this, you are getting very very very high through the air as soon as you open the crystal. but you shouldn’t have any plans afterwards. It might be slightly different methods used while laying, but this is how to do it after the 10 packs of dried they are distributed and eaten up.

LSD is most definitely still around LSD 25 the clandestine laboratories have to operate for only four years to get four years worth of product something like that, though they usually produce enough to last even longer on a typical East Coast tour 100 to 150 g could easily be sold that’s 1,000,000 to 1,000,000 1/2 doses. This flooded these cities and the LSD trickle down to every nook and cranny of America then supporting the small communities

Common misconception about first purity and dosage so I wanted to make this shit clear because it seems that people are still a little confused about this. A lot of people say LSD is LSD and that is that that is not always true. There are different purities of crystal which have different effects you can have tabs from different sources and have a completely different experience without it being an RC however, LSD will always have no taste. Visual with morphine golden visuals other is more geometrical and usually has more body load and leaves me more drained the following days needlepoint very pure 95% white light flakes of crystal silver is good. It’s cleaned 85 to 90% light gray crystal was was around a lot in the 80s and 90s was really what they ate then there’s an amber crystal at 70% which I guess is decent. It’s buried from a light amber color to like it almost dark brown color. One batch called quadriceps amber with the color of light light honey was very good. Lots of people worked with this crystal, but I always would use silver instead since it was better in the same price lavender is 60 to 70% pure white purple to almost black colored crystal like Amber it varies batch to batch and then there’s TJ a tornado juice purity unknown. I’ve seen this shit in about four different colors, and it always scares me. No experience with it than the champagne that’s 50 to 60% pure and then there’s black crystals which are nasty.
1 g equals 1000 mg equals 1001 mg equals 100 hits 1 g equals 10 sheets or a book a sheet is 100 hits or 1 mg if you’re laying a 1 g of pure noodle point in your doses will be 95 MCG because you’re shit will be 70 MCG because it’s 70% pure THANK YOU,
DH TRISMEGISTUS don’t worry about the spelling errors
Would you ever eat a 1g crystal bro?
 
ime some of the analogues have pretty different body highs, and there actually such thing as clean V.S. dirty LSD25 depending on how it's crystalized from what i read. i really know nothing about it scientifically, but i've heard people say that levels of something in the acid will make needle point or whatever have a different high than fluff and what not. i believe it's just the body high. i've had some street acid actually make me feel kind of shitty and some where i felt great. i would guess it was the type of LSD if what i'm saying is true, but i'm not sure. i'm pretty sure the analogues are different though.

i don't think what a person takes will really change the visuals. i believe that's all psychological. i really don't know if i would be able to tell the difference between LSD25 batches myself, but i believe i can tell the difference between eth-lad and ald-52 pretty easy. the eth-lad is more stimulating than even the 1p-lsd and i kind of feel like a tingly burning sensation from eth-lad. ald-52 isn't really stimulating, and i would be mistaken to say it's a downer feel, but when i say it's not stimulating, there is a weird feel different than the others..


sorry if this isn't the point of your thread. i would think you are wrong saying i'm deluding myself thinking they are different though.. i wouldn't want any one to take a dose of any of the analogues and be surprised the body high feels kind of different. maybe some people don't notice the difference. i've done several hundreds of doses of different analogues from those canadian vendors.



lots of google haters, but it usually picks up stuff people have said on the net. i searched "are lsd analogues said to have different body highs than lsd25?" and got "Yes, LSD analogues (lysergamides) are frequently reported by users to have different body highs, intensities, and physical sensations compared to LSD-25. While many popular 1-substituted analogues are thought to act as prodrugs—meaning the body metabolizes them into LSD-25—the user experience often varies in terms of come-up speed, duration, "body load" (physical tension/nausea), and overall "pleasurable high""


would be interested if people think of this. i know i hear a lot of people saying they are the same. it's actually the majority on the net now a days. people in the early 2000's on a site i was on liked eth-lad and said the analogues were different.
LSD wasn’t moved and sold like the cartels move coke and heroin it was handled by a brotherhood truly doing the work of the gods The crystals must be handed by a brotherhood of people who truly believe they were doing the work of the gods or whatever you call creation, we believe that LSD Crystal has to be handled by the right people who are completely committed to the vibrant when we move crystal. There was always a feeling that we were protected. I can’t tell you how many times we should’ve gotten busted but didn’t so many times that it can’t be a coincidence why do I think we’re protected because the family does it for mankind not money we view LSD is the only hope for the world

OK, so you have some crystal and you need to get it on blotter it’s a pretty amazing feeling holding a jar in your hands that has 10 g of crystal in it. That’s 100,000 doses in the palm of your hand for dealing with laying will say we got 1 g of acid is always layered 1 g 10, 10 packs. A 10 pack is a 10 sheets 1 g equals 10,000 doses if you’re laying needle point your doses will be 95% pure if you’re laying Amber, your shit will be 70 µg because it’s 70% pure now you get a glass Pyrex pan to dip your 10 packs in your crystal is dissolved into 110 mL of Everclear program. The pure crystals dissolved instantly with a little stirring the not so pure take a little shaking champagne is damn near impossible to get dissolved evenly paper for white bladder standard watercolor paper #14 this paper is crucial or you’ll fuck it ok so you have your crystal dissolved and your paper cut and ready two schools when it comes to putting it on paper first dumped the solution in the pan and drip each 10 pack into it then lift it up and let’s say excess solution runoff into the pan. Second method is to put the 10 pack into the pan and squirt the solution on it with syringes. I’ve done both and preferred dipping them just because it’s quicker than the 10 packs are laid out to dry, which doesn’t take long since it’s alcohol evaporates like very quickly. If you did it right there will be very little residue left in the bottom of the pan. This residue is extremely potent, and it is either soaked up with a piece of paper called a mop head up or made into a potent liquid called wash the best Acid
While you are doing this, you are getting very very very high through the air as soon as you open the crystal. but you shouldn’t have any plans afterwards. It might be slightly different methods used while laying, but this is how to do it after the 10 packs of dried they are distributed and eaten up.

LSD is most definitely still around LSD 25 the clandestine laboratories have to operate for only four years to get four years worth of product something like that, though they usually produce enough to last even longer on a typical East Coast tour 100 to 150 g could easily be sold that’s 1,000,000 to 1,000,000 1/2 doses. This flooded these cities and the LSD trickle down to every nook and cranny of America then supporting the small communities

Common misconception about first purity and dosage so I wanted to make this shit clear because it seems that people are still a little confused about this. A lot of people say LSD is LSD and that is that that is not always true. There are different purities of crystal which have different effects you can have tabs from different sources and have a completely different experience without it being an RC however, LSD will always have no taste. Visual with morphine golden visuals other is more geometrical and usually has more body load and leaves me more drained the following days needlepoint very pure 95% white light flakes of crystal silver is good. It’s cleaned 85 to 90% light gray crystal was was around a lot in the 80s and 90s was really what they ate then there’s an amber crystal at 70% which I guess is decent. It’s buried from a light amber color to like it almost dark brown color. One batch called quadriceps amber with the color of light light honey was very good. Lots of people worked with this crystal, but I always would use silver instead since it was better in the same price lavender is 60 to 70% pure white purple to almost black colored crystal like Amber it varies batch to batch and then there’s TJ a tornado juice purity unknown. I’ve seen this shit in about four different colors, and it always scares me. No experience with it than the champagne that’s 50 to 60% pure and then there’s black crystals which are nasty.
1 g equals 1000 mg equals 1001 mg equals 100 hits 1 g equals 10 sheets or a book a sheet is 100 hits or 1 mg if you’re laying a 1 g of pure noodle point in your doses will be 95 MCG because you’re shit will be 70 MCG because it’s 70% pure THANK YOU,
DH TRISMEGISTUS don’t worry about the spelling errors

Would you ever eat a 1g crystal bro?
thats 10,000 doses so maybe if I had a few years for a sabbatical
 
LSD is an organic/synthetic drug much more stable and much more soul the visuals I get from LSD25 have a higher dimensional construction You can absolutely tell the difference in LSD25 it is conceived as a sacrament for self discovery and spiritual journeys, LSD25 presented it enhancing promise, a portal to access higher dimensions of consciousness, transcending social feathers. It was this promise that urged individuals to critically appraise and challenge social structures, instigating a paradigm shift towards individuals and the collective consciousness expansion you get your ass kicked if you come into my town with an analog version of LSD if you’re straight up with exactly what it is then you just got a verbal warning 25 was responsible for the summer of love it absolutely matters for shared hallucinations, & synchronicity psychedelics are not what we in my family fuck with we ARE BLESSED WITH real LSD…however the benzodiazepines and other miscellaneous sedatives and opioid RC’s Are good, that’s just my opinion. We make that real shit 25 you lie to yourself if you think those RC versions of acid are truly like the real thing tried taking 1000 micrograms of real LSD 25. There’s no mistaking who is king. I take 5000 at least 6-8 times per year and you can’t get to that level on RC’s the rest of the year 600 is my norm. I would like to be introduced to some more RC psychedelics but so far all of them just fall very short of mescaline & LSD. If you know your drugs 25 has a connection with an element that is truly blessed.
So how would I know if I am getting just good LSD or this heavenly ALD-52 LSD? ...Or is ald52 just ..LSD and not any analogs?

I'm asking because as far as I can tell .my gel tabs have been consistent with blotters from the past, and they never have a taste. Are all analogs bitter? Or just the nbomes or whatever?
Fucking acid, wish I could try all of the analogs but then again my tasteless stuff seems to be the real deal.?
 
So how would I know if I am getting just good LSD or this heavenly ALD-52 LSD? ...Or is ald52 just ..LSD and not any analogs?
I was about to say it would be very difficult to distinguish between actual LSD and the prodrugs but... Bunk Police claims:
Ehrlich ReagentHoffmanMarquis
LSD-25Pinkish/magenta (instant)Soft purple (instant)No reaction
1P-LSDNo reaction (1 min) Then pinkish after hydrolysisNo reaction (1 min) Then purple after hydrolysisSoft reddish/purple
1cP-LSDNo reaction (1 min) Then pinkish after hydrolysisNo reaction (1 min) Then purple after hydrolysisNo reaction
NBOMe (DANGER)No reactionYellow/orangeBright yellow/green (instant)



So apparently the pro drugs react noticeably slower to the Ehrlich compared to LSD itself. This makes sense as the prod rug will slowly convert/hydrolyze to LSD due to the acid and water content of the reagent itself (ethanol, hydrochloric acid, H2O, dimethylaminobenzaldehyde) before it reacts with the DMAB..

I didn't think you could use a reagent kit myself but there you go.

Also super relevant. I recently stumbled on a paper about a super long chain LSD pro drug that they are claiming could be used as an extended release form of LSD due to it's high fat solubility. I wasn't able to really project estimated duration from their data, but it's interesting to prove that as the ester group gets longer, the efficiency of metabolic hydrolysis itself decreases.

Essentially the pro drugs should have extended come ups and total duration as the compound side chain gets bigger.

"The HTR data confirmed that 1DD‐LSD produces behavioral effects mirroring those induced by serotonergic psychedelics such as LSD. However, the increased N1‐acyl chain length in 1DD‐LSD led to noticeable reduction in potency compared to lower homologues, such as ALD‐52, 1P‐LSD, 1B‐LSD, and 1V‐LSD. Further clinical testing is necessary to assess the abuse potential of 1DD‐LSD and to evaluate its pharmacological interactions and the qualitative nature of its effects in animals and humans. In addition, the pharmacokinetic properties of 1DD‐LSD need to be investigated. Based on the HTR data, 1DD‐LSD appears to have an extended duration of action compared to LSD and other N1‐acyl‐substituted homologs, possibly because it is sequestered in fat, potentially protecting it from enzymatic hydrolysis. Further studies are warranted to investigate whether depot forms of 1DD‐LSD should be developed by adjusting the formulation or by creating lipophilic esters that are sequestered in fat and slowly released and metabolized."


 
Last edited:
I recently stumbled on a paper about a super long chain LSD pro drug that they are claiming could be used as an extended release form of LSD due to it's high fat solubility.
I wouldn't want an extended release LSD personally - 12-14h before being able to sleep is usually long enough! - but it's 27x less potent in animals, so maybe this is like an extended release microdose kind of thing. Perhaps at such a low dose it wouldn't interfere with sleep.

I have met people before who are able to sleep on acid and that just seems so impossible to me. We're really all wired a bit different.
 
I wouldn't want an extended release LSD personally - 12-14h before being able to sleep is usually long enough! - but it's 27x less potent in animals, so maybe this is like an extended release microdose kind of thing. Perhaps at such a low dose it wouldn't interfere with sleep.

I have met people before who are able to sleep on acid and that just seems so impossible to me. We're really all wired a bit different.
Me either. I really liked AL-LAD due to it's recreational aspect and noticeably shorter duration.

As far as the pro-drugs, I've only tried the ALD-52/1A-LSD and while it was great, I'm not sure I could distinguish it from good LSD itself. Haven't particularily been interested, though I've always been very happy to see lysergamides available to the masses.
 
@Didgital the only LSD prodrug I've tried was 1p-LSD and I don't think I can tell it apart from LSD. My assumption is that 1A and the other prodrugs are similar enough or the same, so not worth seeking out for me. I agree about being happy about the availability, a truly great thing in this mad world.

AL-LAD, ETH-LAD and MiPLA were definitely distinct though, and I think LSZ was too but it was a long time ago so need to try it again.
Of that bunch, LSZ was probably the most similar to LSD but with a touch of boring, but again it needs another fair shake.
 
@Didgital the only LSD prodrug I've tried was 1p-LSD and I don't think I can tell it apart from LSD. My assumption is that 1A and the other prodrugs are similar enough or the same, so not worth seeking out for me. I agree about being happy about the availability, a truly great thing in this mad world.

AL-LAD, ETH-LAD and MiPLA were definitely distinct though, and I think LSZ was too but it was a long time ago so need to try it again.
Of that bunch, LSZ was probably the most similar to LSD but with a touch of boring, but again it needs another fair shake.
Ehh I was not a huge fan of LSZ, it was inconsistent IME, but always a bit spacier than LSD. ETH/AL-LAD were excellent, but aside from LSZ I never got to (knowingly) try any of the N substituted compounds (MIpLA, EIPLA, LME-54, LAE-32) but I think it'd be cool to see AL-EIPLA for example..
 
The biggest strength of MiPLA (imo) is having a relatively short-lived lysergamide. It felt nice too, maybe a bit softer than LSD but hard to tell if that's just because it's pretty weak in comparison. I never tried any of the other ones like EiPLA LAE-32 but they are intriguing for sure.

Seems like the overall consensus on LSZ was that it was slightly a dud, but I still want to try it again and try to go in without that bias because sometimes the consensus overlooks a gem. I remember there was a long period where most everyone threw shade on 5-MeO-DMT for example, but my reading on the overall vibe is that it is more appreciated now than it was say 15 years ago.
@Didgital
 
The biggest strength of MiPLA (imo) is having a relatively short-lived lysergamide. It felt nice too, maybe a bit softer than LSD but hard to tell if that's just because it's pretty weak in comparison. I never tried any of the other ones like EiPLA LAE-32 but they are intriguing for sure.

Seems like the overall consensus on LSZ was that it was slightly a dud, but I still want to try it again and try to go in without that bias because sometimes the consensus overlooks a gem. I remember there was a long period where most everyone threw shade on 5-MeO-DMT for example, but my reading on the overall vibe is that it is more appreciated now than it was say 15 years ago.
@Didgital
My problem with LSZ was that it seemed to be rough on the guts and a very highly effective laxative (even ondansetron couldn't keep it under control). A collectors piece rather than fun...
 
But to answer the original question, in my experience I've tended to find ALD-52 to be dependably delightful. I'm certainly not going to pretend that it's anything other than subjective bias (the equivalent of a "red underpants' day...), but as set and setting is very much a mindset issue, it makes sense to cross your fingers and... well... metaphorically put on your lucky underpants.
 
Essentially the pro drugs should have extended come ups and total duration as the compound side chain gets bigger.

I think that depends because the time it takes to peak also depends on transport rates within the gut and/or the blood-brain barrier. A longer alkyl chain may decrease polarity of the molecule which could have the effect of speeding up transport. The time to peak versus chain length may be a U-shaped. This is all just in theory of course.
 
Anyone who knows a thing or two about acid knows that there are also countless RC analogues or 'pro-drugs' for good old 25. What I am referring to here are the 1-x-LSD variants, and not ETH-LAD, AL-LAD, or anything else.

I understand that these LSD 'pro-drugs' are pretty much indistinguishable from LSD-25, unless you want to delude yourself into thinking they have unique properties; (I would understand a slower come up due to hydrolysis) what I am asking is if they are technically less potent by weight than LSD-25 - because If they are really a 'pro-drug', then the added groups (the propionyl, valeryl, etc.) would have an added weight to the molecule - meaning that their breakdown would result in a lighter version of the final product? If so, could you scientificlly tell exactly how much weaker?

Help me understand.

Though I suppose the only way to know for sure would be to do a true blind test with what is confirmed to be 100ugs of LSD-25 with 100ugs of an LSD prodrug - but then again there will always be issues with set and setting and the subjects involved.

Damn you acid with your enigmatic nature
 
Top