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Benzos Clobromazolam / Phenazolam Megathread

if you tried real pyrazolam and not the bs china sold it as "desalkylgidazepam, or bromazolam depending on dose/effects) felt , it was extremely special.


No high, euphoria, cognitive impairment, just made me feel very sober and normal.
 
pcplease said:
if you tried real pyrazolam and not the bs china sold it as "desalkylgidazepam, or bromazolam depending on dose/effects) felt , it was extremely special.


No high, euphoria, cognitive impairment, just made me feel very sober and normal.
Click to expand...

I believe earlier in the thread I detailed the activity of each homologue.

Pyrazolam - anxioytic with selective a3/a4 affinity
Pyeyzolam - alcohol mimic with selectice a5 affinity
Pynazolam - potent serotonin releaser with a3/a4 affinity

So pynazolam is, more or less, midway between diazepam and MDMA.
 
notsmokeymcpot42088 said:
a benzo with MDMA like effects sounds like the holy grail. serotonin so no MAOI's (Same as MDMA).

very interesting/promising about the most excited ive been about a substance since I heard oxymorphone was going to hit the market (but before I knew they'd ruin it thoroughly in pill form).

I don't think I ever noticed the damn n and thought you were talking about pyrazolam the whole time and kept thinking 'there was nothin special bout that one' (To me at least)
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Well - know what you have, go slow and I would not recommend it's use if a person is prescribed MAOI inhibitors. Cohort size was 87 and median dose was 11.4mg - but franky, 10mg is what I consider safe. I took a lot more and just wound up lying in bed. I felt very good - but I just didn't want to do ANYTHING. Lying there was perfect for me.

But consider the cohort size, median dose and warnings. We went slowly and carefully knowing what we had. While we had a reasonable cohort size, it's not enough to assert inherent safety.

TBH first into man was me, first into woman was my wife, first into son was my son.

My safety metric isn't ME, it's my son. I simply ask 'would I be happy for him to consume THIS compound' and yes, the majority were discarded. You will disgard the vast majority of designs if you really take safety seriously.

BTW may son was in his 20s at the time.
 
I doubt he understands what you mean, but simply put, recreational/regular benzos, especially triazo or "-Lam"'s, have high affinity for a1.

a1- Loss of executive function, blackouts, and a feeling of euphoria due from the loss of cognizance, Logic starts to fade, and all your troubles get washed away.
 
pcplease said:
I doubt he understands what you mean, but simply put, recreational/regular benzos, especially triazo or "-Lam"'s, have high affinity for a1.

a1- Loss of executive function, blackouts, and a feeling of euphoria due from the loss of cognizance, Logic starts to fade, and all your troubles get washed away.
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As I think I mentioned, we purposefully designed a 'frustrated a1 ligand' i.e. it could bind but essentially it just blockaded the a1b1y2 receptors. So it was the a3/a4 that brought the profound tranquility and the robust serotonin release that amplified that tranquiliy.

I won't lie - we ALL asked each other 'is this one TOO good' i.e. our concern was that it MIGHT be subject to abuse. That is why our initial proposal was that a 5mg dose at bedtime would bridge the gap between a patient presenting with clinical depression and conventional antidepressants becoming active. But we simply lacked the resources to do this.
 
I respect the absolute hell out of that, acknowledging it publicly. I hope you live to see it come to fruition, and if i recall correctly, you have a son or someone to pass down this info too. It will be needed. The alcohol substitute. Pyrnazolam and pyrazolam potential for treatment of anxiety.

Japan I expect a long time before they start treating an alcohol as a problem, it ever, and treat benzos as more dangerous drugs of abuse. I respect how they use them, as 30/day make treatments that build up enough to hopefully have enough buildup to where enough has built up that the patient can discontinue with lasting effects for a long time. Mexazolam quickly (maybe not so much for them given they are often alcoholics) becomes delorazepam and lorazepam. 3x/day for 30 days, and that's it. With liver impairment that delorazepam is going to build to incredibly high levels quickly.

It certainly did for me, and I felt its effects for days after 1 day taken as prescribed. Scared to take it unless necessary, just in case, and would rather a small dose of 3-OH-phenazepam which also lasts a couple days and know it's not going to be in my system more than a couple weeks, max. It works better for me ( and some) due to benefiting from a little loss of amnesia and cognitive function. My level of cognizance and memory can easily be problematic
 
notsmokeymcpot42088 said:
a benzo with MDMA like effects sounds like the holy grail. serotonin so no MAOI's (Same as MDMA).

very interesting/promising about the most excited ive been about a substance since I heard oxymorphone was going to hit the market (but before I knew they'd ruin it thoroughly in pill form).

I don't think I ever noticed the damn n and thought you were talking about pyrazolam the whole time and kept thinking 'there was nothin special bout that one' (To me at least)
Click to expand...
thats pretty much just clonazolam
 
vlzinspace said:
thats pretty much just clonazolam
Click to expand...

Yeah - I expect it would be more or less the same. The key difference is that the nitrogen at the 8-position cannot be metabolized (reduced) by the body. I think earlier in this thread I noted that for some odd reason, nitrobenzodiazepines are far more toxic than other benzodiazepines and that the toxicity appears to be a function of the potency e.g. patients prescribed 1mg fluitrazepam (Rohypnol) were, on a per prescription basis, dying as frequently as those prescribed nitrazepam (Mogadon) which is odd as one might expect the former to be safer. To be clear, these were intentional overdoses but it just looked so strange to me that those two benzodiazepines were responsible for ALL the fatalities.

That's why we went with the far more difficult pynazolam. Pynazolam is excreted from the body unmetabolised so we didn't have to worry about potentially toxic metabolites.

So we never went complex for the sake of it, we went with the safest scaffold we could find.
 
well i suppose i'll guinea pig myself since i cannot seem to find info on clobro / alcohol mix. of course, its not good, but we shall see how not good lol. going to sip 12% alcohol, had 2mg clobro 6 hours or so ago. will report the info here. i usually like to lowdose alc with a benzo albeit dangerous, i do just a touch
 
vlzinspace said:
well i suppose i'll guinea pig myself since i cannot seem to find info on clobro / alcohol mix. of course, its not good, but we shall see how not good lol. going to sip 12% alcohol, had 2mg clobro 6 hours or so ago. will report the info here. i usually like to lowdose alc with a benzo albeit dangerous, i do just a touch
Click to expand...

I have to admit to not concentrating. PyEYzolam is the alcohol mimic, not pyNAzolam that was more or less a serotonin releaser that was a 'frustrated' a1 ligand i.e. it would compete for a1 occupancy but couldn't then adopt the active conformation.

With pyNAzolam we found 5-10mg to be the active range. Now I really would assume clonitazolam would be more potent. But we avoided the existing nitrobenzodiazepines for the reasons explained i.e. people under the influence of such compounds sometimes suffer a loss of judgement (loss of executive function) on the lines of 'this feels great, I will consume some more' and that, with nitrobenzodiazepines, can be a bad thing.
 
took 2 mg of clobro, drank 12% 200ml alcohol, took another 1 mg clobro little bit later.

surprisingly unexciting. my usual kick is to take a bromazolam with a beer, and it would create a euphoric effect somewhat akin to cocaine/alc. with the clobro/alcohol i didn't seem to even feel them interacting at all. my lil anecdote
 
vlzinspace said:
took 2 mg of clobro, drank 12% 200ml alcohol, took another 1 mg clobro little bit later.

surprisingly unexciting. my usual kick is to take a bromazolam with a beer, and it would create a euphoric effect somewhat akin to cocaine/alc. with the clobro/alcohol i didn't seem to even feel them interacting at all. my lil anecdote
Click to expand...

Well, that presumes the compound isn't being misrepresented OR that pynazolam requires that pendent pyridyl moiety. We went with it after observing that the French anxiolytic (bromazepam) only underwent 3-hydroxylation i.e. reliable pharmokinetics. But we discovered that the addition of a triazolo ring prevented even the 3 hydroxylation i.e. they are all excreted unchanged. As you can imagine, no metabolites (especially active metabolites) makes establishing kintetics a much simpler task.

So while pyrazolam took ages to synthesize, with that compound in hand, we could play with the 8 substituents. Too costly for the RC market but if used in medicine, a practical option.
 
pcplease said:
if you tried real pyrazolam and not the bs china sold it as "desalkylgidazepam, or bromazolam depending on dose/effects) felt , it was extremely special.


No high, euphoria, cognitive impairment, just made me feel very sober and normal.
Click to expand...
Noticed how one vendor “sold out” of bromonordiazepam the moment pyrazolam dropped again. Not trying to make any accusations but holy fuck they are playing the market. Now we are at double the average price instead of triple.

BTW the clobromazolam is subtle until you close your eyes, v undecided about the dose in these pellets, one green 2mg pellet should be equivalent to 80mg diazepam? Im at 5-10mg norflurazepam daily and actually feel clear. I have like half a pill,1mg-ish in my system. Insane how sedating norflurazepam is I might need to reconsider this taper.

Nice benzo but tbh I just want flualprazolam 2.0.
 
Esperighanto said:
Got my hands on 100mg of crystal phenazolam, shit is like the euphoria of Valium, hard-hittingness of Xanax and an even longer perceived length of action than Klonopin. I would however say that it's unnecessarily sedative, for my tastes at least.
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Tolerance/dose?

I am getting lackluster results. Pellers are supposed to be 2mg but im taking halves.

It makes the mini-rattle ic-26 gave me bearable at least. Only have the chills and lethargy, no puking and it has been 3 days since dosing. I was 3 days on it, right when my previous 10 day 10g dope ended that rattle was very mitigable with kratom just have to resist buying extracts cheaper than their already cheap quality kratom, dont bother with anything but red varieties. 65 grams continuously dose got me to a worse point im at now. Postage fucked up and of course i couldnt resist.




Btw i tried a 4mg avizafone pellet, sadly not compatible with my tolerance.

Maybe i should go to the gp while dopesick, sadly ill be better before the time has passed to induce benzo wd. I just want to stabilize and reduce 10 percent per week.
Sadly bromonordiazepam doesnt take all the wds away, rather get on that for a bit.

I was contemplating finishing a taper with pyrazolam.
 
Huh?

If I want anxiolytic properties I made the wrong choice? Feels subjective.

What SHOULD I want from a bezno? You tells me
 
TheFunkeeJunkee said:
I can *feel* differences between X benzo and Y benzo but the differences aren't ever enough to draw a meaningful distinction. As I can with opioids, 2a agonists, NMDA antagonists etc but it seems to me within these drug classes there exists a diverse array of effect profiles, whereas with benzodiazepines you don't get that diversity of effects within a single class.

I think even with psychedelics most people couldn't not meaningfully differentiate in a double blind 2C-C from 2,4,5-TMA for instance. I can't recall the exact paper (I could find it if you'd be interested) but in it, human participants couldn't reliably pass a drug discrimination test between psilocyn and DXM. Some did, others didn't.
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Tbh I fully agree with that I cannot ”feel” the difference in benzodiazepines outside onset, duration etc like you said. Some vary slightly in muscle relaxation or delusions of sobriety but theyre all very similar.

But it has me thinking, I know I can feel differences in psychedelics, stimulants dissod etc. But maybe were making an unfair comparison comparing entire drug classes to a single scaffold? If we instead compared GABAergics as a whole then I can certainly feel and notice differences in them.

Same as with dissociatives a lot of PCx analogs feel similar, with stimulants a lot of phenidates or pyrros feel similar or with psychedelic drugs in similar scaffolds they feel similar too. Though I must still say that benzos are the scaffold where I feel the least differences, maybe it has something to do with the inhibiting nature of GABAergic drugs clouding your judgment as well
 
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