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"Legal" RC synthetic opiods?

There are indeed others right now (...I'm not aware of any 'before'), but I won't name them here, because I don't want to inspire all those opioid addicts out there to obtain some presumably safe (and maybe legal) alternative. We are talking about some quite potent shit, that call for casualties.

As was said before: Opioids are definitively nothing to be sold as RCs. Low safety margin meets potential letality meets high addiction liability. That just calls for fatalities! Arrgh! Let me quote FnB (see p.1 of this thread):
Hope none ever make it to the RC market as they are a disaster waiting to happen. Look at the irresponsible use of mephedrone etc, then translate that to legal RC opiates - many deaths will ensue
Click to expand...
And oh yes Sir, he's so goddamn right!

- Murphy
 
There are indeed others right now (...I'm not aware of any 'before'), but I won't name them here, because I don't want to inspire all those opioid addicts out there to obtain some presumably safe (and maybe legal) alternative. We are talking about some quite potent shit, that call for casualties.
Click to expand...

I am not an opioid addict. Potent don't call for casualties. Dumb vendors and users call for casualties (see BDF/2c-b-fly thread).
 
High potency definitely results in casualties. It's no surprise when people OD on fentanyl (even with known, measurable doses) constantly and less frequently with heroin- which has far less sure doses.
 
Hammilton said:
High potency definitely results in casualties. It's no surprise when people OD on fentanyl (even with known, measurable doses) constantly and less frequently with heroin- which has far less sure doses.
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You are right on that one.
 
Didnt someone on here sell this stuff from Denmark. a whole bunch of RC opiods in the ug range.
He was also a pedophile or something. Anyone remember that?
 
I posted this in another thread, but no one will likely look at it. It is an article discussing the seizure potential of tramadol and its metabolites.

The fact that one of the enantiomers of tramadol might be particularly
potent (potency in terms of seizure potential) was not found to be the case; the (+)- and
(–)enantiomers were about equipotent to tramadol. The
fact that the M1 (aka o-desmethyltramadol) metabolite or its enantiomers might be particularly potent was also not found to be the case. M1 and
its (+)- and (–)enantiomers were less potent than tramadol
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http://jpet.aspetjournals.org/cgi/reprint/325/2/500.pdf
 
Does that mean that it is LESS potent than tramadol or just that it has LESS seizure potential than tramadol?!
 
Yes, less potent as seizure inducing agents...

I would still be cautious...

Personally the spasticity from tramadol at 800mg seemed somewhat benign, but can certainly be problematic for others.
 
hamhurricane said:
ive used p. bicolor skin secretions which contain dermorphin and many other related peptides. i rubbed the secretions into an open wound (in the amazon) and did not find it especially recreational, moderate euphoria, there are some ethnobotanical vendors which sell the secretions though.
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Hamilton Morris???? Lol
 
I know I'm bumping an old thread but what about currently??? Are there any good moderately potent opioid rcs on the market other than the usual fent analogues or mitazimes that are everywhere?? I was looking for something weaker like ODSMT as a maintenance
 
hamhurricane said:
ive used p. bicolor skin secretions which contain dermorphin and many other related peptides. i rubbed the secretions into an open wound (in the amazon) and did not find it especially recreational, moderate euphoria, there are some ethnobotanical vendors which sell the secretions though.
Click to expand...

I wonder if it would be safe to administer kambo via syringe.
 
I've noted that certain vendors look at animal models of pain and assume that such models automatically translate to the objective and subjective effects in man. In the 1990s a researcher in Austria found a series of compounds that were potent analgesics but importantly, mediated that analgesia via both the MOR and DOR receptors. So hard to know what the subjective effects would be in man.

But more recently I've noted at least two compounds that at first glance appear to be extremely potent but on closer inspection are more active at the KOR receptors than the MOR or DOR. Similarly, another class recognized to primarily mediate analgesic activity via NOP activity were on offer.

I have no idea if they were ever actually synthesized by the vendors but when the total price of all the precursors is far higher than the price that the compounds are being offered, something is clearly no quite right.
 
4DQSAR said:
I've noted that certain vendors look at animal models of pain and assume that such models automatically translate to the objective and subjective effects in man. In the 1990s a researcher in Austria found a series of compounds that were potent analgesics but importantly, mediated that analgesia via both the MOR and DOR receptors. So hard to know what the subjective effects would be in man.

But more recently I've noted at least two compounds that at first glance appear to be extremely potent but on closer inspection are more active at the KOR receptors than the MOR or DOR. Similarly, another class recognized to primarily mediate analgesic activity via NOP activity were on offer.

I have no idea if they were ever actually synthesized by the vendors but when the total price of all the precursors is far higher than the price that the compounds are being offered, something is clearly no quite right.
Click to expand...
Hey now, they must just have a hell of a recipe that allows for a super high return rate 🤣
 
This Was The RC That Killed Prince. But Don't Worry. He's Back Now.

3,4-Dichloro-N-%5b(1R,2R)-2-(dimethylamino)cyclohexyl%5d-N-methylbenzamide.png


U-47,700
3,4-Dichloro-N-(1R,2R)-2-(dimethylamino)cyclohexyl-N-methylbenzamide
 
7 oh? Not totally illegal or unavailable yet!

I know partial agonist --- I didn't read the whole thread.....FTR.

I think some nitrazenes (Sp) may be in the grey area -- but I don't know if they sealed that up in the last 10 or so years.
 
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