Health Daily psilocybin use with my Quetiapine ok?

[Opi_Kid_Rock]

Dear BL Fam,

I have been taking pure psilocybin 20-30mg(*typo edited) per day while I take 50mg Quetiapine for sleep each night. I feel I am currently dependant on the Quetiapine for sleep after I had been on it for 4 years due to PTSD recurring dreams in the past. I have just gotten off suboxone 2mg/day for 30 days. My question is, is it fairly safe in the short and long term to be combining the daily psilocybin and Quetiapine, or do they work against each other -brain chemical wise?
The psilocybin helps with my chronic headaches, where I sometimes take CBD in addition, in search for relief. Thank you for everyone's input.

OpiKR

 

[JackARoe]

I have been taking pure psilocybin 200-300mg per day while I take 50mg Quetiapine for sleep each night.

Hey OP, not sure on the contraindications of this combo. I have zero experience with quetiapine. (or any antidepressants or anti psychotics for that matter) But i have to go back to my notes. I thought an average dose psilocybin was 15 mgs. Is that a typo?

If I were to guess? Quetiapine would prevent full effect of psilocybin. I thought I had read here at BL it can be used to completely kill a trip. But I myself am not 100% sure. But someone in the BL fam for sure has mixed these two and had some result.

 

[foodcrisis]

have heard some people say they trip on anti-psychotics, but i'd think if you were using them daily, they wouldn't really have any effect... personally i can't trip on AP's with my average doses that i'd take with out them at all. like i did a couple grams of shrooms on risperdal which is another AP and got zero effect. that's not everybody, but it's a pretty popular opinion, and a lot of people claim AP's especially the one you are using to be "trip killers"

personally, i don't think a lot of people's microdosing schedules that they find helpful would have any effects on me like at all.... i really think that stuff is just placebo from what i experience... even just thinking with out drugs can cause people to release brain chemicals.... i'm not gonna say people that microdose daily are wrong and aren't getting results because of the drug... i just know something completely different goes on in my brain when i take a dose of shrooms after taking some time off. there has to be some tolerance with daily use. from what i understand most psychedelics build tolerance pretty quickly, but it goes away in a few days to a couple weeks.... like i said though, different stuff could be going on with microdosing and i just don't notice it... when people going on psych meds they usually are stronger and have other side effects at the start, but they will continue to help the person when the original side effects of the drug wear off. i would think that's cause there is a tolerance to the drug, but it still works... definitely different types of drugs, so that might not really be anything, but i do hear people claim that psychedelics and AP's will still make them trip or feel good and people do microdose daily.

i don't think it's really known if anything is bad about psychedelics kind of combatting the effects of the AP's... i've thought of that before, like if it stresses the brain out. i think it'd show up on search engines if it were known. probably not a big deal and won't effect most people if there's nothing on the net at this point about it. i'm sure a ton of people tried... so if it's working for you, i guess it's probably not a big deal.. let me know if anybody can find anything why it's bad to combine psychedelics and AP's other than it might not be good for mental health or the AP's will dull the psychs.. i don't think it's toxic or going to give serotonin syndrome or whatever can happen crossing certain types of drugs.

 

[Quasimoto]

Dear BL Fam,

I have been taking pure psilocybin 200-300mg per day while I take 50mg Quetiapine for sleep each night. I feel I am currently dependant on the Quetiapine for sleep after I had been on it for 4 years due to PTSD recurring dreams in the past. I have just gotten off suboxone 2mg/day for 30 days. My question is, is it fairly safe in the short and long term to be combining the daily psilocybin and Quetiapine, or do they work against each other -brain chemical wise?
The psilocybin helps with my chronic headaches, where I sometimes take CBD in addition, in search for relief. Thank you for everyone's input.

OpiKR

I assume you mean 200-300mg of mushroom material (??). 300mg of pure psilocybin would be like eating 30 grams of mushrooms every day, which would probably land you in a psych ward eventually, heh.

Mushrooms contain approximately 10mg of psilocybin per gram, but this can vary by strain and size of the shroom.

But no, I don't see any major contraindication here. But I would watch out for side effects for sure, because that's not a micro dose. It's not a macro dose either. That's a threshold dose.

As others have mentioned, the quetiapine is going to block the effects of mushrooms, but if it helps with your headaches it might be worth it.

If you are actually eating 300mg of pure psilocybin every day... that is a very bad idea and will eventually lead to psychosis and other very negative effects on your brain. Too much neurogenesis is a bad thing.

 

[foodcrisis]

^^^^i wasn't aware they were taking a large dose. i assumed it was a typo when poster JackArose mentioned... maybe they are on a larger dose cause it dull the effects. the same thing i wrote stands about tolerance that i wrote even if they are taking a lot.

 

[Didgital]

No one is taking 300mg of pure psilocybin a day. We can move past that.

 

[JackARoe]

No one is taking 300mg of pure psilocybin a day. We can move past that.

Also is pure psilocybin even available beyond the people that are in the know? I mean with mushrooms how can one even know how many milligrams they are taking. They are so variable.

Hopefully the OP comes back and tells us what he does and what he is going to do.

Slightly OT but since headaches were mentioned I used to get cluster headaches. From age 26 to 48. Every spring and fall I would wake up every other night feeling like an ice pic was stabbing the side of my head. I’d fall asleep and wake up exactly 2 hours after like that. The only thing that helped me was caffeine. Morphine even made it worse. It’s a shitty thing to have to take caffeine in the middle of the night to get back to sleep. Luckily, I grew out of the cluster headaches. I had read as people get older that you do grow out of them and for me that was true. However, there was no information on psilocybin and cluster headaches back when I had them. And I would also do mushrooms occasionally, but I never noticed they would stop a cycle. I even had a cluster headache after a nice LSD trip. Yet there’s literature on these substances, helping both migraines and cluster headaches. I just never noticed anything. My cycles would only last about three weeks.

 

[Sylvia Thyssen]

Might be ok. Snap.

 

[Esperighanto]

Daily dosing indolic psychedelics is super ineffective for microdosing. Imo you should "barely" be able to feel a microdose, I often refer to it as "thresholding" instead of "microdosing", but finding the threshold point for mushrooms is something you need to feel out after homogenizing the batch into powder, and keep in mind that it'll only last 3-4 months (even in proper storage conditions) until it begins to weaken. I found that taking a threshold dose every 2-4 days was the sweet spot, wicked low doses can be done every other day, moderate to larger doses will leave that good good afterglow for something like 3-4 days in my experience.

If you want hyperconsistent fungi, grow them yourselves from the same culture and the same growth/drying/storage conditions. As a former cultivator, it's a pain in the ASS to get batches super consistent, hell recent evidence even indicates a small-but-present difference in potency between caps and stems.

 

[Opi_Kid_Rock]

Hey OP, not sure on the contraindications of this combo. I have zero experience with quetiapine. (or any antidepressants or anti psychotics for that matter) But i have to go back to my notes. I thought an average dose psilocybin was 15 mgs. Is that a typo?

If I were to guess? Quetiapine would prevent full effect of psilocybin. I thought I had read here at BL it can be used to completely kill a trip. But I myself am not 100% sure. But someone in the BL fam for sure has mixed these two and had some result.

Hi JackARoe,

I checked the packaging for my psilocybin capsules and they say they are 30mg each capsule that I take.

 

[paranoid android]

Also is pure psilocybin even available beyond the people that are in the know? I mean with mushrooms how can one even know how many milligrams they are taking. They are so variable.

Hopefully the OP comes back and tells us what he does and what he is going to do.

Slightly OT but since headaches were mentioned I used to get cluster headaches. From age 26 to 48. Every spring and fall I would wake up every other night feeling like an ice pic was stabbing the side of my head. I’d fall asleep and wake up exactly 2 hours after like that. The only thing that helped me was caffeine. Morphine even made it worse. It’s a shitty thing to have to take caffeine in the middle of the night to get back to sleep. Luckily, I grew out of the cluster headaches. I had read as people get older that you do grow out of them and for me that was true. However, there was no information on psilocybin and cluster headaches back when I had them. And I would also do mushrooms occasionally, but I never noticed they would stop a cycle. I even had a cluster headache after a nice LSD trip. Yet there’s literature on these substances, helping both migraines and cluster headaches. I just never noticed anything. My cycles would only last about three weeks.

Never had cluster headaches but i have had migraines and shrooms really helped mine. For migraine attacks i found the best thing for it back in the day was demerol aka pethedine with dramamine. I dont know if demerol would even work on me now seeing as i have somewhat of a what looks like permanent tolerance going on with opiates. It's pretty weak but was good for some stuff like migraines and also stomach pain. I had it once in hospital for food poisoning and it worked pretty well for that as well.

 

[Opi_Kid_Rock]

Also is pure psilocybin even available beyond the people that are in the know? I mean with mushrooms how can one even know how many milligrams they are taking. They are so variable.

Hopefully the OP comes back and tells us what he does and what he is going to do.

Slightly OT but since headaches were mentioned I used to get cluster headaches. From age 26 to 48. Every spring and fall I would wake up every other night feeling like an ice pic was stabbing the side of my head. I’d fall asleep and wake up exactly 2 hours after like that. The only thing that helped me was caffeine. Morphine even made it worse. It’s a shitty thing to have to take caffeine in the middle of the night to get back to sleep. Luckily, I grew out of the cluster headaches. I had read as people get older that you do grow out of them and for me that was true. However, there was no information on psilocybin and cluster headaches back when I had them. And I would also do mushrooms occasionally, but I never noticed they would stop a cycle. I even had a cluster headache after a nice LSD trip. Yet there’s literature on these substances, helping both migraines and cluster headaches. I just never noticed anything. My cycles would only last about three weeks.

Hi JackARoe,

I personally started experiencing worse tension/migraines as I got older. I'm starting to pay close attention to what I put into my body, and quit those entirely. While emotional stress could cause my headaches to flame up again.
I was wondering if LSD mini trips or full trips could help keep my headaches away, or if all this messing around with the chemical balance of my brain made them worse. Just a general food for thought I'm putting out there I guess. Thanks for your replies/feedback.

 

[Opi_Kid_Rock]

I assume you mean 200-300mg of mushroom material (??). 300mg of pure psilocybin would be like eating 30 grams of mushrooms every day, which would probably land you in a psych ward eventually, heh.

Mushrooms contain approximately 10mg of psilocybin per gram, but this can vary by strain and size of the shroom.

But no, I don't see any major contraindication here. But I would watch out for side effects for sure, because that's not a micro dose. It's not a macro dose either. That's a threshold dose.

As others have mentioned, the quetiapine is going to block the effects of mushrooms, but if it helps with your headaches it might be worth it.

If you are actually eating 300mg of pure psilocybin every day... that is a very bad idea and will eventually lead to psychosis and other very negative effects on your brain. Too much neurogenesis is a bad thing.

I typed it wrong. I checked the packaging and it says 30mg psilocybin capsules. Sorry about that.

 

[JackARoe]

Never had cluster headaches but i have had migraines and shrooms really helped mine. For migraine attacks i found the best thing for it back in the day was demerol aka pethedine with dramamine. I dont know if demerol would even work on me now seeing as i have somewhat of a what looks like permanent tolerance going on with opiates. It's pretty weak but was good for some stuff like migraines and also stomach pain. I had it once in hospital for food poisoning and it worked pretty well for that as well.

Migraines and clusters are different but both vascular. Honestly I have not researched in years as mine did go away and luckly I lost interest. But some years after clusterbusters and a few other sites were coming around. I would love to have had that info when I was going through stuff but it was not around. It is said even just a mini dose in early Spring or Fall could help adjust the cycle so it goes away quicker.

Demerol is a little different than say morphine. So maybe that would have worked. If I took morphine during a cluster cycle I would almost for sure make the headache worse. Not sure why. I know caffeine helps with vasoconstriction. Maybe that itself narrowed whatever was pounding on my brain.

Hi JackARoe,

I personally started experiencing worse tension/migraines as I got older. I'm starting to pay close attention to what I put into my body, and quit those entirely. While emotional stress could cause my headaches to flame up again.
I was wondering if LSD mini trips or full trips could help keep my headaches away, or if all this messing around with the chemical balance of my brain made them worse. Just a general food for thought I'm putting out there I guess. Thanks for your relies/feedback.

Thanks for clarifying OP. 30 mgs makes more sense. Still intrigued on packaging.

Tension headaches are very different from migraine or clusters. I am not sure it is the same. So something like clusterbusters probably does not apply. That is the headache/psychedelic as medicine site. CBD probably much better. I have to say since daily kratom, plain leaf, I have not had a tension headache in years. But I use to use ibuprofen for them before that. Whatever it takes to get relief I would do though.

OP if you do give it a shot and see if the quetiapine/psilocybin experiment works, give us an update.

 

[Opi_Kid_Rock]

These so called psilocybin capsules I buy have misleading labeling. The 250mg capsule must be a stack of other non-psilocybin mushroom like their other product; while it only says psilocybin capsules on the packaging.

I should go to an actual shroom shop to know what I'm buying.

 

[Didgital]

These so called psilocybin capsules I buy have misleading labeling. The 250mg capsule must be a stack of other non-psilocybin mushroom like their other product; while it only says psilocybin capsules on the packaging.

I should go to an actual shroom shop to know what I'm buying.

You're better off just growing your own. A good amount of mushroom products out there contain rc's such as 4-aco-DMT and who knows what else.

Growing your own is cheaper and you actually know what's in them.

 

[Esperighanto]

I was wondering if LSD mini trips or full trips could help keep my headaches away, or if all this messing around with the chemical balance of my brain made them worse. Just a general food for thought I'm putting out there I guess. Thanks for your replies/feedback.

Set, setting and intention will really guide the impact of psychedelics on somebody in my experience.

Growing your own is cheaper and you actually know what's in them.

Great advice here imo, but also RCs like 4-AcO-DMT are equally worth exploring imo as they're very likely just prodrugs to psilocin. Hell, Shulgin thought he couldn't tell miprocin from ethocin from psilocin in TiHKAL.

 

[Nas47]

man...i dunno how is possible to combine nasty grand tranquilizers with visiogens???One blocks most of ur dopamine and serotonion receptors....others like triptamins acts like agonist on serotonin type receptors....drink this seroquel(which is a terrible thing for me) if u really helps u......or take triptamins only....can't imagine to mix mushrooms with anything else except little bit of weed after the trip....but that's only me and eveybody is insane these days

 

[Esperighanto]

man...i dunno how is possible to combine nasty grand tranquilizers with visiogens???One blocks most of ur dopamine and serotonion receptors....others like triptamins acts like agonist on serotonin type receptors....drink this seroquel(which is a terrible thing for me) if u really helps u......or take triptamins only....can't imagine to mix mushrooms with anything else except little bit of weed after the trip....but that's only me and eveybody is insane these days

Imo it's about the mixture of doses. For example, 150ug of LSD and 7.5mg of diazepam still has a full trip, but with a uniquely bright vibe to it. Upbeat thought processes, seemingly even more color enhancement, more empathogenic sorts of feelings, I think that sedative + psychedelic combos have their place and time but it's very underexplored as of yet imo.

 

[Opi_Kid_Rock]

I've been off 50mg Quetiapine for 4 days now. I'm looking to stay off it. The psilocybin and LSD have given me some headache relief, but I'm still surprised how mild headaches return every 4 days or so.