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  • BDD Moderators: Keif’ Richards | negrogesic

Opioids Opioid stacking

J

jerseyshark

Bluelighter
Joined
Jan 11, 2021
Messages
153
Location
Florida
I have had members alluded that stacking produces positive synergy with oxycodone. So, not to beat the subject into the ground, my question to ya'all is if this scene you take a couple of M3(30 mg codeine/300 tylenol) pills , wait 60-90 min and take 2 10mg percocet (total 20 mg oxy and 600 mg tylenol). The objective: to reduce percocet use by combining with another opioid (codeine), and, increase synergy of oxycodone by the combination. So. Does "stacking" actually work? Can someone explain in scientific terms how it does...Thank everyone. JS
 
I can't answer your question ( it's an interesting one) but I suggest that you make your topic more clear and specific in your title. "Opioid" is pretty general. This way someone is more likely to notice and answer, I think.
 
Codeine slows the metabolism of oxycodone. The former is some x18 less potent than the latter so I would suggest that any 'synergy' is a product of increase plasma levels of oxycodone.

But mixing stuff is generally a bad idea.

Oh, and you might consider taking a methionine supplemnent to protect your liver from paracetamol (acetaminophenol) damage. Health food shops sell it.
 
GulpingBatteryLiquid said:
Why not just do more oxy? Codeine is pretty lame recreationally and it makes you extermely itchy. When I dose high on codeine I have to strip off and vigorously rub myself with a towel
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While I'm only too aware of the addictive nature of oxycodone, adding codeine to the mix didn't notably alter the experience. BUT it did HUGELY increased my tolerance due to it slowing down the metabolism of the oxycodone.

In short - you get nothing from it but a worse habit.

I'm not in a position to compare it to simply having a worse oxycodone habit, I was shocked at how the mixture damaged my life.

Also, mixing stuff just increases the possible risks. I discovered the interaction the hard way.
 
4DQSAR said:
Codeine slows the metabolism of oxycodone. The former is some x18 less potent than the latter so I would suggest that any 'synergy' is a product of increase plasma levels of oxycodone.

But mixing stuff is generally a bad idea.

Oh, and you might consider taking a methionine supplemnent to protect your liver from paracetamol (acetaminophenol) damage. Health food shops sell it.
Click to expand...
I'm trying to understand what you mean. I gather that codeine and oxy compete for the same receptors for metabolization. So there is a limit in general to how fast you can metabolize, and therefore your body is "wasting" some of it's ability to do so on the weaker codeine? This means you have higher levels of it in your blood waiting for the opportunity to be metabolized? Does this mean the oxy effect becomes weaker at any given point in time but more drawn out ( longer lasting)? Sort of becomes an extended release drug rather than an instant release?
I guess the other question that occurs to me is, CYP26 metabolizes many more things than opiates. Does occupying it with the metabolism of codeine and oxy keep it from doing it's job on other drugs and substances? I've never heard it said so, but that seems like an implication, at least to my unknowledgeable mind.
 
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chippermonk said:
I'm trying to understand what you mean. I gather that codeine and oxy compete for the same receptors for metabolization. So there is a limit in general to how fast you can metabolize, and therefore your body is "wasting" some of it's ability to do so on the weaker codeine? This means you have higher levels of it in your blood waiting for the opportunity to be metabolized? Does this mean the ixy effect becomes weaker at any given point in time but more drawn out ( longer lasting)? Sort of because an extended release drug rather than an instant release?
I guess the other question that occurs to me is, CYP26 metabolizes many more things than opiates. Does occupying it with the metabolism of codeine and oxy keep it from it's job on other drugs and substances? I've never heard it said so, but that seems like an implication, at least to my unknowledgeable mind.
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YES - exactly that.

If you take codeine before oxycodone, the oxycodone's elimination half-live is increased. Take enough codeine and oxycodone will last 24 hours.

Of course, it means your tolerance and dependence rockets up. I know because I was prescribed both and when the doctor decided it was better to stop the codeine and increase the oxycodone, I went through withdrawal in spite of being given what is suppose to be an eqipotent increase in my oxycodone.

The full kick. Not fun.

So I do not recommend the mixture as dependence occurs quickly and the rattle is evil. The full puking, shitting, eye-watering, nose-running and every single part of the body aching like crazy rattle that goes on for weeks.
 
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Extended relese oxycodone with 100mg/1ml tramadol oral solution is working wonderful ( be careful, i am on anticonvulsants, dont take high dose if u are not ). I write this ONLY because tramadol Is synthetic derivative of codeine and prodrug too.
 
BadBoy377 said:
What about mixing codeine and dihydrocodeine?
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Well, dihydrocodone IS active - it's not just a prodrug. But on the other hand, it's not anywhere nearly as potent as oxycodone. So if enough codeine is consumed, the metabolism of DHC will be slowed but I don't think it would be as big an issue.

But I tell you - the sheer panic when I realized what was going on followed by understanding and then knowing I would have to sit still for withdrawal. Why not tell the doctor you may ask. Well, the reason the doctor didn't want me taking codine was her stating 'codeine is to addictive'. Addiction is a psychological issue, dependenc quite another but I do wonder if she used a term I would more easily understand.

But it's pretty horrific.
 
Aye, codeine is actually very addictive as we both know. Probably due to the fact it's active at other receptors too. It was you that made me aware of that.
 
But yeah I didn't notice much benefit to mixing the two. Codeine and dihydrocodeine. Other than you can stack the dhc on a couple hours after a hefty codeine dose. In terms of general please I actually think codeine is slightly better.

Stacking tramadol and tapentadol and codeine was interesting. 300/100/150 ish kinda doses. A little edgy from the tapentadol. Wouldn't recommend from a safety point.
 
I'm curious about how stacking kratom with other opiates works. I hear it isn't a good idea, that it messes up tolerance. I also feel like it works on various pathways that true opioids don't and this could cause problems. It also can make really nauseous at higher doses and I wouldn't want to stimulate that.
I'm not asking because I really want to. I don't feel any need to. Just curious. I don't think common wisdom about opioids necessarily applies to kratom.
 
chippermonk said:
Active at other receptors how so?
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A very knowledgeable friend showed me this...

pubmed.ncbi.nlm.nih.gov

Codeine produces a cholinergically mediated analeptic effect in rats and rabbits - PubMed

The intravenous administration of codeine to diazepam-narcotized rabbits resulted in a shortened duration of loss of righting reflex. Coadministration of naltrexone plus codeine enhanced this analeptic effect and was also effective in shortening the duration of pentobarbital narcosis. The...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Very interesting
 
BadBoy377 said:
But yeah I didn't notice much benefit to mixing the two. Codeine and dihydrocodeine. Other than you can stack the dhc on a couple hours after a hefty codeine dose. In terms of general please I actually think codeine is slightly better.

Stacking tramadol and tapentadol and codeine was interesting. 300/100/150 ish kinda doses. A little edgy from the tapentadol. Wouldn't recommend from a safety point.
Click to expand...

When you mixe stuff, you are always increasing the risk over and above a simple addative mix.

Tapentadol is an odd one. I looked into it and while it'a MOR affinity is low, it appears to act as a SUPERaconist i.e. it activates the site more then the body's endogenous opioids.

It appears the nitazenes are both potent AND are superagonists so I foresee a major problem for anyone who becomes physically dependent i.e. there is no dose of methadone or buprenorphine that will fully substitute. I hate to say it but to me, nitazenes seem like a one way street. I mean, FANTASTIC for the dealers but very bad for the consumers.

But with nitazenes and fentanyl analogues on the market, nobody could compete on price. Someone COULD produce an alternative that was much better subjectively (and there are still some examples that are quite potent i.e. x80 M) but we are seeing Grisham's law played out in the most tragic manner.

Take care ofr yourself, man!
 
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4DQSAR said:
When you mixe stuff, you are always increasing the risk over and above a simple addative mix.

Tapentadol is an odd one. I looked into it and while it'a MOR affinity is low, it appears to act as a SUPERaconist i.e. it activates the site more then the body's endogenous opioids.

It appears the nitazenes are both potent AND are superagonists so I foresee a major problem for anyone who becomes physically dependent i.e. there is no dose of methadone or buprenorphine that will fully substitute. I hate to say it but to me, nitazenes seem like a one way street. I mean, FANTASTIC for the dealers but very bad for the consumers.

But with nitazenes and fentanyl analogues on the market, nobody could compete on price. Someone COULD produce an alternative that was much better subjectively (and there are still some examples that are quite potent i.e. x80 M) but we are seeing Grisham's law played out in the most tragic manner.

Take care ofr yourself, man!
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I also read that Nitazeni are dangerous. A lot.
But you're probably talking about another drugs, not the tapentadol (palexia).
But having tried tapentadol up to 300 mg. a day, I had no effect, and had it changed to oxy then fentanyl and methadone
Bye
 
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