Why dont long lasting benzos like librium and clonazepam cause rebound anxiety?

[Okiv99]

Im talking in a one time/short term use situation. If i dose on xanax or valium even once ill get rebound anxiety. But in the case of these two very long lasting (not long half life but long effects benzos) I have never got rebound anxiety unless using for more thn a couple of days. Why is this the case? Do the effects just taper off slow like they come up slow so u dont feel any?

 

[SeekingOblivion]

They definitely do in my experience if you use them regularly. They have a longer half life and leave the system more slowly though, so there’s that.

 

[Coffeeshroom]

I also have exp rebound anxiety from clonazepam too but I do use it daily and the last few decades. Benzos in overall, currently back on diazepam, still the best rounded benzo for me.

Maybe it's the short term usage and the long half life but if you keep it up any benzo when stayed long enough on will cause rebound anxiety if you just stop or run out or whatever the case may be.

Just be careful and try to keep usage to a minimum or not at all if not really needed.

 

[Dextro .45]

Longer acting benzodiazepines have reduced liability to cause this due to thier long acting active metabolites

Valium (Diazepam) and even a better one Delorazepam (marketed in Italy) and is also an active metabolite of Diclazepam (2-Chloro Diazepam) . Delorazepam is used as a very long acting anxiolytic benzodiazepine and is further metabolized into Lorazepam (Ativan) .....so they stay active for 78-200 hours and are slowly metabolized and excreted from the body

A super short acting benzodiazepine like Alprazolam (Xanax) while an effective rapid acting anxiolytic & antidepressant also have a faster clearance....so rebound anxiety is more likely

A common practice is a rapid acting short half life Alprazolam (Xanax) 1-2mg ......and a long acting anxiolytic like Valium (Diazepam) 10mg after 4-6 hours so it provides anxiolytic/muscles relaxation for longer and is still active inside the body several days after (with steady state dosing / daily / week)

Diazepam 10mg tablets & Alprazolam 1mg tablets would be all you'd need....with Pregabalin 150mg capsules and a Clonidine 0.1mg an hour before bed......for Serious PTSD / chronic stress/ panic attacks etc

For me, a 240 lbs / 6" tolerant man.....my cocktail would be:

Diazepam 30mg
Alprazolam 2mg
Pregabalin 300 - 450mg
Clonidine 0.1mg (half tablets hour before bed) and optional / not needed in most cases

 

[chris_p]

Im gonna completely agree with OP here simply based on the fact that I was on a regimen on 2mg kpins a day (1mg in the morning and 1mg in the evening) and never remember experiencing any significant withdrawal. It was a long time ago so maybe I just didn't feel it as strongly, but compared to my extremely short term use of xanax (2-5mg a day for about 2 months) which resulted in extreme anxiety and sometimes suicidal ideation whenever I didn't have access to it, there is definitely a huge discrepancy here in withdrawals. This is all anecdotal, so don't take it as fact

 

[Okiv99]

I also have exp rebound anxiety from clonazepam too but I do use it daily and the last few decades. Benzos in overall, currently back on diazepam, still the best rounded benzo for me.

Maybe it's the short term usage and the long half life but if you keep it up any benzo when stayed long enough on will cause rebound anxiety if you just stop or run out or whatever the case may be.

Just be careful and try to keep usage to a minimum or not at all if not really needed.

Valium felt no different to xanax for me. It has a way longer half life on paper but in terms of its onset and the length of its actual effects it felt almost equal.

 

[Coffeeshroom]

Valium felt no different to xanax for me. It has a way longer half life on paper but in terms of its onset and the length of its actual effects it felt almost equal.

And that's why we all don't get the same benefits from said benzo cause of our bodies being different. For me alprozalam has no muscle relaxing properties and is only good for me when I get extreme anxiety out of nowhere then it has it place. We all different why we need to find what works for us.

 

[Okiv99]

I also have exp rebound anxiety from clonazepam too but I do use it daily and the last few decades. Benzos in overall, currently back on diazepam, still the best rounded benzo for me.

Maybe it's the short term usage and the long half life but if you keep it up any benzo when stayed long enough on will cause rebound anxiety if you just stop or run out or whatever the case may be.

Just be careful and try to keep usage to a minimum or not at all if not really needed.

Yh I think the worry for me with my clonazepam usage is its so long lasting I could take it say 4 days apart and still have some in my system and build dependence tht way.

 

[Coffeeshroom]

Yh I think the worry for me with my clonazepam usage is its so long lasting I could take it say 4 days apart and still have some in my system and build dependence tht way.

Okay but now I'm asking you this. Why you using. For medical reasons or recreational. This helps give us and yourself for future use what to do and expect. I personally think any benzo used constantly (daily) for 3 weeks and plus and then stopped even if tapered will cause rebound anxiety.

 

[Okiv99]

Okay but now I'm asking you this. Why you using. For medical reasons or recreational. This helps give us and yourself for future use what to do and expect. I personally think any benzo used constantly (daily) for 3 weeks and plus and then stopped even if tapered will cause rebound anxiety.

Just job interviews etc. I got a bit of social anxiety after isolating myself with kratom for a while. Now im going bk into the real world been using propanolol most days allon with exercise (helps allot) then tougher things like job interviews I take a bit of klonopin. I wont ever use daily most has been twice a week I hated kratom withdrawal and read benzo withdrawal is way worse and the paws is way way longer. Also I just dont find it addictive the way I found kratom.

 

[Coffeeshroom]

Just job interviews etc. I got a bit of social anxiety after isolating myself with kratom for a while. Now im going bk into the real world been using propanolol most days allon with exercise (helps allot) then tougher things like job interviews I take a bit of klonopin. I wont ever use daily most has been twice a week I hated kratom withdrawal and read benzo withdrawal is way worse and the paws is way way longer. Also I just dont find it addictive the way I found kratom.

Glad to read that and with that said and approach, you should really have no issue with addiction or even rebound anxiety but doesn't make it impossible.

Rebound anxiety can be self triggered and now you don't have something in your system to help making you feel it more pronounced I would say.

But if it's for those sole purposes you good and congrats on wanting to be part of society so to speak again and integrate or engage. Hard to step out your comfort zone sometimes.

 

[euphoricc]

you said it --=LONG LASTING comes on slow and leaves as slow thats why i have been on them for 14 years 3 mg a day i came home from marines and my ptsd was bad i stayed inside for a month only went to get weed i thought i was still at war........aggravating

 

[StylishKidsInRiot]

It doesn’t sound like anyone here has actually been addicted to benzos, which is such a blessing.

Over time of daily usage, Clonazepam, because of the super long half life, is by far the worst one for rebound anxiety, mania, helmet head, etc..

After a weekend binge or a few days, Alprazolam is the worst as it’s the shortest duration with the most intense euphoria..

 

[StylishKidsInRiot]

you said it --=LONG LASTING comes on slow and leaves as slow thats why i have been on them for 14 years 3 mg a day i came home from marines and my ptsd was bad i stayed inside for a month only went to get weed i thought i was still at war........aggravating

I highly recommend you taper down, or stop completely. This is how it brainwashes you. The long half-life is actually working against you. You are in the honeymoon stage of Clonazepam addiction and if you’ll know exactly what I mean if you continue for a month and stop completely..

 

[StylishKidsInRiot]

I must say, I just started frequenting these forums again and I’m shocked that nobody has noted this here yet and reached out to assist…

 

[Keif' Richards]

I think in general, they do cause rebound anxiety to the same degree that any other Benzodiazepine can cause this symptom. There are differences between the Benzodiazepines obviously, but in broad terms, they all do the same thing and are mostly differentiated by their duration of action as opposed to their minute differences.

Everybody is different. Your subjective experience here is not invalid. These Benzodiazepines are longer-acting. It's a well-established phenomenon that drugs with a longer duration are thus going to cause slower changes in blood levels, thus making it more difficult for a person to discern these differences.

What you're describing is pretty normal reaction.

 

[SeekingOblivion]

I think in general, they do cause rebound anxiety to the same degree that any other Benzodiazepine can cause this symptom. There are differences between the Benzodiazepines obviously, but in broad terms, they all do the same thing and are mostly differentiated by their duration of action as opposed to their minute differences.

Everybody is different. Your subjective experience here is not invalid. These Benzodiazepines are longer-acting. It's a well-established phenomenon that drugs with a longer duration are thus going to cause slower changes in blood levels, thus making it more difficult for a person to discern these differences.

What you're describing is pretty normal reaction.

You’re totally right. With some subtle variations they all do the same thing. I am a bit of an aficionado and have tried all of them, including obscure ones (not RCs though).

 

[Esperighanto]

Diazepam 30mg
Alprazolam 2mg
Pregabalin 300 - 450mg
Clonidine 0.1mg (half tablets hour before bed) and optional / not needed in most cases

I've never used pregabalin but if I assume that 4 adequately spaced out doses of 300mg of gabapentin add up to roughly this, that would be a crazy ass combination. I've recently found tizanidine, hydroxyzine, and promethazine to all combine to something greater than their individual parts, any two of the three as well. I rarely exceed 50-75mg of either hydroxyzine or promethazine, taking less of one than another, and then decide if some lines of tizanidine would be nice.

@SeekingOblivian I've used benzos and various drugs on and off through my entire life, often taking years off at a time just because I didn't feel like using them. I don't think it's guaranteed that addiction occurs in the first place, but they sure are fun and make things like alcohol completely not worth it to me, personally.

 

[Keif' Richards]

Hey @SeekingOblivian I know that there are Benzodiazepines out there that have significant differences than the 3-4 very common drugs that are prescribed for anxiety and such.

Midazolam (Versed) is very potent and very short-acting. It is most commonly used for anesthesia though I know people who have used them in tablet form. In a hospital, they can give you a continuous flow of the drug through your IV catheter. The short-acting nature of the drug means they can easily knock you out fast and in turn bring you out quickly.

Anyway, I know what I was like when I was young and didn't know anything about the pills I was taking. People saying "oh man, xanny bars hit you harder than anything else bro". Rappers are talking about using Xanax; I can see how people might develop preferences partiall due to true differences in the drugs, but also due to social reinforcement.

In the end, a Benzo addict isn't gonna complain if you're giving him Chlordiazepoxide (Librium) or Alprazolam (Xanax) or Clonazepam (Klonopin). They all work. I guess my obscure point here is that the differences are minute between these drugs, though mental reinforcement/conditioning also play a big role in what someone's preference might be.

I'm not a Benzodiazepine guy though. I would only use them whenever I was doing Amphetamines. They didn't do anything for me outside of helping take the edge off of stimulants.

Opioids are and have always been my thing. I can understand how, when you've done something long enough, you are gonna specialize. For instance, Oxymorphone (Opana; Numorphan) is my favorite of all time. It is a 9/10. Hydromorphone (Dilaudid) is an 8/10 and (Diacetyl)Morphine is a comfortable 7.5/10.

@Esperighanto for future reference 600mg Gabapentin (Neurontin) = 100mg Pregabalin (Lyrica). I feel from experience that this figure is pretty accurate. Of course, once you start going higher in dosage with the former, you start running into a complex pharmacokinetic situation that is too much to describe here.

 

[AngelsandFairiesarereal]

Years ago I was taking massive amounts of Xanax … my doctor was actually prescribing them. After a couple years of it I started getting really bad panic attacks and had to move. The new doctor said that I was probably getting panic attacks because I was getting inter dose rebound anxiety because Xanax has such a short half life. So he cut my Xanax dose in half and also prescribed me clonazepam because he said that clonazepam has much longer half life than Xanax and it will smooth out the rebound anxiety. He said to take the clonazepam and only take Xanax as needed. It actually really did work.

*However we all have different back stories and I have severe PTSD (and my ex that was stalking me, found out where I was staying so I had to move again) … anyways so I had a lot going on. The panic attacks were definitely 80-90 % slowed down though when I made that switch to clonazepam. lol hope any of that made sense