RCs New RC-Benzos that Work as Prodrugs for Already Existing Ones (Clonazafone, Diclazafone, etc.)

[Mana0909]

Good Evening​

I think everyone remembers the old RC-Benzos that led to so many overdose incidents and how withdrawal symptoms were already showing after just three days.
Clonazolam, Flubromazolam, Flunitrazolam, etc.

Now we have benzodiazepines like Bretazenil. It's a special benzo that isn't as addictive as the standard ones, and I can agree with that.
In almost every trip, I got some form of dysphoria. It never lifted my mood even a bit, but it was very effective.

Rilmazafone, a Japanese benzo, isn't actually one. It's a prodrug that becomes active once it's in the blood and metabolizes to "Rilamzolam."

1mg of Rilmazafone equals:

• 10mg Diazepam
• 0.5mg Alprazolam
• 0.5mg Clonazepam
• 0.5mg Bretazenil
• 20mg Temazepam

Now, in the last two years, more "-zafone" substances have appeared in RC shops, like:

• Clonazafone - (Clonazepam prodrug)
• Diclazafone - (Diclazepam prodrug)
• Avizafone - (Diazepam prodrug)
• Noravizafone - (Nordazepam prodrug)

There are also "-Desglycyl" versions of these new prodrugs to make them more potent! Does anyone have experiences with the new "benzo prodrug-trend"?

Stay Safe, Mana0909

 

[Dextro .45]

Diclazepam (2-Chloro Diazepam) is a great compound, actually synthesized by the same polish chemist who made Diazepam (Valium), Klonopin and Librium.

Diclazepam 1mg metabolism into 3 legitimate benzodiazepines......the most significant being Delorazepam 78h half life, then finally into Lorazepam (Ativan).

Diclazepam is like the Methadone of benzodiazepines and is longer acting that Valium

Chlorodesmethyldiazepam (Delorazepam) is prescribed in Italy as a long acting anxiolytic benzodiazepine which then metabizes into Lorazepam (Ativan)

Diclazepam isn't very pleasurable or enjoyable but it's a very potent & long acting anxiolytic benzodiazepine. I bought over 1,500mg of Diclazepam and still have a healthy inventory. 2-3mg is a very robust dose and you'll be tranquilized for several days of anxiety free relaxation. A single mg is sufficient but 2mg is best . 2-3 actually

Avizafone (Pro-Diazepam) is also great. I purchased several grams ....oral administration is ok but wasn't getting that real Valium feel .....so I took Avizafone 50mg and SC injection under skin pinched stomach and pocked needle in to bypass first pass metabolism and in 5 to 10 min I was feeling great

Avizafone 22.5mg
Diazepam 10mg ....if I remember correctly

 

[Esperighanto]

Diclazepam isn't very pleasurable or enjoyable but it's a very potent & long acting anxiolytic benzodiazepine.

I've heard so many people claim it's noticeably euphoric and functional, I wonder what leads to the subjective differences in how these are all perceived. Given diclazepam is strong enough to fit on blotter, I'm shocked it hasn't been further propagated since that would theoretically allow the trafficking of the substance to occur by just moving paper, instead of things authorities notice easier like pills or powders. I've never come across diclazepam, but how long would you say the noticeable effects last, a 78h half-life doesn't exactly mean it's noticeable for that long, but it can mean that too.

 

[ShulginsReincarnation]

Good Evening​

I think everyone remembers the old RC-Benzos that led to so many overdose incidents and how withdrawal symptoms were already showing after just three days.
Clonazolam, Flubromazolam, Flunitrazolam, etc.

Now we have benzodiazepines like Bretazenil. It's a special benzo that isn't as addictive as the standard ones, and I can agree with that.
In almost every trip, I got some form of dysphoria. It never lifted my mood even a bit, but it was very effective.

Rilmazafone, a Japanese benzo, isn't actually one. It's a prodrug that becomes active once it's in the blood and metabolizes to "Rilamzolam."

1mg of Rilmazafone equals:

• 10mg Diazepam
• 0.5mg Alprazolam
• 0.5mg Clonazepam
• 0.5mg Bretazenil
• 20mg Temazepam

Now, in the last two years, more "-zafone" substances have appeared in RC shops, like:

• Clonazafone - (Clonazepam prodrug)
• Diclazafone - (Diclazepam prodrug)
• Avizafone - (Diazepam prodrug)
• Noravizafone - (Nordazepam prodrug)

There are also "-Desglycyl" versions of these new prodrugs to make them more potent! Does anyone have experiences with the new "benzo prodrug-trend"?

Stay Safe, Mana0909

Do you have any additional resources which discuss the -desglycyl versions of these prodrugs?

All I could find is this here: https://workpage.ews-nfp.bg/wp-cont...WS-RCS-FN-2024-0028_Diclazafone-desglycyl.pdf

Pretty helpful, but I am looking for something more specific and detailed regarding these compounds.

Thanks.

 

[Mana0909]

Do you have any additional resources which discuss the -desglycyl versions of these prodrugs?

All I could find is this here: https://workpage.ews-nfp.bg/wp-cont...WS-RCS-FN-2024-0028_Diclazafone-desglycyl.pdf

Pretty helpful, but I am looking for something more specific and detailed regarding these compounds.

Thanks.

Yes, because those are "-zafone" and "-desglycyl" of German origin, I don't think you would find that much information. Search, for example

"Clonazafone/Diclazafone/Avizafone Desglycyl" and then put "reddit" or "eve rave" after it.

example: diclazafone desglycyl eve rave

Clonazafone = Clonazepam (prodrug)
Avizafone = Diazepam (prodrug)
Diclazafone = Diclazepam (prodrug)

Info: eve rave is the German version of bluelight.org, but I would say it's even more active, at least in my experience. I can't link any shops here to those products, of course, and I won't, but on reddit and especially on eve rave, you are going to find more information on those new prodrugs.

I have to go now. I'm currently trying out a new "ethyl-" benzodiazepine, and it's becoming more and more difficult to focus. I'm going to answer everything when I'm back tomorrow. Have a good night.

Have a good night, BL. Mana0909

 

[Dextro .45]

I've heard so many people claim it's noticeably euphoric and functional, I wonder what leads to the subjective differences in how these are all perceived. Given diclazepam is strong enough to fit on blotter, I'm shocked it hasn't been further propagated since that would theoretically allow the trafficking of the substance to occur by just moving paper, instead of things authorities notice easier like pills or powders. I've never come across diclazepam, but how long would you say the noticeable effects last, a 78h half-life doesn't exactly mean it's noticeable for that long, but it can mean that too.

Actually….when I take Diclazepam 2-3mg I feel the subtle onset in 1.5 / 2 hours and then it gradually becomes more apparent

The REAL magic happens the next day…..due to its slow metabolism and 3 active metabolites being made active, the user will notice robust anxiolytic effects 2-3 days after…..even longer with daily steady dosing as it can build up to higher levels in bloodstream, which COULD be dangerous and lead to unsafe levels of Delorazepam & Lorazepam in the subject

I usually use mine in a Brompton Cocktail …..but it’s not the best suited compound for such thing. A rapid acting potent benzodiazepine with rapid clearance and fast metabolizing much safer

Diazepam (Valium) 10mg tablets is hands down the best benzodiazepine ever synthesized
Alprazolam (Xanax) 2mg bars are the second best anxiolytic & antidepressant compound

 

[marcoman]

Interesting post and the term "pro-drug" which I haven't heard- is appears to seem quite similar to a "precursor" - that when it metabolizes in the body it changes the compound structure. Which may be similar to steroid precursor stuff (muscle building types) Thus, allows us "commoners" to acquire them without the worries of "torture nd prosecution" from our ruling class bastards and bitches.. But back to the OP's post, I'd have to guess things may very in obtaining them in different countries though. And the actual potency in comparison to the ones we already know about - that exist in the Big Pharma Mafia..I mean Industry.

In regards to the benzo family and it's effects, I have tried almost all of the popular ones here in the United States of Slaves...i mean AmeriKa'..and never experienced any real euphoria. My "buzz" from them is really no buzz at all. I'm a hyped up guy, lots of energy, a racy mind. You've probably seen those types of people as they appear to be on speed or some upper. (excuse the term "upper" I'm an old guy, "a stupid boomer" as someone here recently posted that, and btw, thanks man ,<note eye roll>) That's a completely separate discussion though, as I really dislike being put into the "boomer box" and its snarky, disrespectful insinuation.

Anyway fkn way, benzos are my magic bullets, esp, clonazapam (sorry, I call them k-pins (short for klonopin, boomer talk ) and 2nd magic bullets are Valiums (us idiot boomers call them V's) They slow my racing mind down and I feel as though I can fiannly take a big sigh and as if a 100 pound weight comes off my shoulders. Bu what I try to tell other people what benzos do for me is that they make me feel "normal." Since they basically just slow me down (and my world) I can think clearer and better and not feel so overwhelmed, over-stimulated with life in general.

Yes, how I am (from a medical diagnosis) falls into a lot of categories as I've been through the ringer of docs, specialist, shrinks, etc. I've had these docs put me all over the place with dx's like, ADD/ADHD, OCD, somewhere on the Autistic/Aspergers spectrum, and more. I'm 66, hitting 67 in June...so I've been this way since my early teenage days, maybe sooner. The other benzos are not helpful for me at all, esp. Xanxax and Ambien which many people seem to love. I hate them, lol. I'll skip the details why i dont like them as this post has dragged on further than I wanted it to. Plus every doc I saw had me try just about any drug known to man in attempts to help me. Final Summary: Clonazapam and Diazapam. That's it. For those who me here (and my story) my doc cut me off my k-pin script as she (out of the blue) decided she no longer wanted to script it as I also take oxycodone (5mg 3x a day) The risk of ODing being the reason why the cut-off. Although the concerns from her and the contraindications involving oxy and benzo is a reality, I get it. BUT! for 6+ years I have been on the same dosages without any problems. I still have y oxy script but I am forced to search elsewhere to get either clonazapam or valium. I'm trying to do it through another doc and just be totally honest and upfront with them. I'm also searching other ways to get them.

Bottom line: I have two drugs that work for me. I've been through a shitload of docs. I tried everything possible, pharma, cannabis, ketamine, microdosing mushrooms, herbs, etc etc. I DON"T WANY ANYTHING ELSE. (maybe that's a part of being a "Boomer"...stubborness) LOL. So my search will continue until I find what I want (K-pins or V's). And I have to careful that I don't get red flagged for doctor hopping or appearing like a junkie. And also have to be careful if I go to the streets or online.

So yes, this "pro-drug" thing- possibly same meaning as "pre-cursor" option may be a good avenue to explore. Thanks to OP for the post, I hope it stays up and we can continue the discussion on it.

 

[marcoman]

I've heard so many people claim it's noticeably euphoric and functional, I wonder what leads to the subjective differences in how these are all perceived. Given diclazepam is strong enough to fit on blotter, I'm shocked it hasn't been further propagated since that would theoretically allow the trafficking of the substance to occur by just moving paper, instead of things authorities notice easier like pills or powders. I've never come across diclazepam, but how long would you say the noticeable effects last, a 78h half-life doesn't exactly mean it's noticeable for that long, but it can mean that too.

Having it on paper would be quite fkn awesome!

 

[Esperighanto]

Also worth clarifying for this thread is that a prodrug is something that's converted into the active consistent in vivo, a precursor is something that's used ex vivo to produce an active constituent, hopefully by a chemist but typically by a fool. Most things considered precursors are a huge pain in the ass to synthesize or maintain under the same atmosphere we exist in right now. The real difference to keep in mind is that one is done in the body, one in a lab.

 

[marcoman]

Also worth clarifying for this thread is that a prodrug is something that's converted into the active consistent in vivo, a precursor is something that's used ex vivo to produce an active constituent, hopefully by a chemist but typically by a fool. Most things considered precursors are a huge pain in the ass to synthesize or maintain under the same atmosphere we exist in right now. The real difference to keep in mind is that one is done in the body, one in a lab.

Thanks for clarifying that. I learned something.

 

[Mana0909]

First things first: I wish everyone a very beautiful morning or early noon (im living in the timezone UTC/GMT+1, meaning its currently 11:57am for me)

Diazepam (Valium) 10mg tablets is hands down the best benzodiazepine ever synthesized

When you like Diazepam this much, then I can recommend you "Nordazepam," also known as nordiazepam, desoxydemoxepam, and desmethyldiazepam. It's like Diclazepam, an active metabolite of Diazepam, and is considered the benzodiazepine with the longest half-life currently known: 40 - 200 hours.

It's primarily used as an anxiolytic drug, meaning it's used against panic and anxiety disorders, but it also has amnesic, anticonvulsant, muscle relaxant, and sedative effects (from strongest to weakest). In my opinion, it has many similarities to Diazepam but is overall weaker. Some brand names are: Nordaz, Stilny, Madar, and Vegesan.

Overall, 10mg of Nordazepam equals 5 - 6mg of Diazepam, meaning it's way weaker than Diclazepam and is basically (in my opinion) on the level of Oxazepam (Adumbran) and Chlordiazepoxide (Librium). I'm not a fan of Alprazolam nor Lorazepam. The only good "anxiolytic" benzo is "Bromazepam/Bromazanil" because it doesn't make me as emotionless, dysphoric, dead inside, and tired. Nordazepam is on the same level as Bromazepam and Diazepam for me, meaning I would give it a 3.5/5 in total, but considering your taste, you should definitely check it out.

Recommendations: Bromazepam and Nordazepam

@Esperighanto, thank you for explaining the differences in such a short and nice compact text. I'm truly impressed that you knew this difference too. I only found out about this fact 2 months ago in my university. That was actually one of the first topics in my medicine study, and I must say that I love it. I mean, in general, getting more and more knowledge about how the body works, how medication, plants, etc., actually work and why they do the things they do. The entire history, from shock therapy to barbiturates to methaqualone and now the benzodiazepines. I also got the feeling that gabapentinoids, especially Lyrica, are slowly replacing some of the benzodiazepines, which I can understand in some way.

Only because of the small fact that I agreed to take a drug this one day, it evolved all the way up to a fascination with medicine and especially neuroscience. It still amazes me how 2mg of a powder, a tiny pellet, can change your mood from the most depressed to the happiest in just a couple of minutes. That's also why transmitters like serotonin, dopamine, norepinephrine, oxytocin, etc., are called "the rulers of this world," because they decide how we feel and how we act. That's also why dopamine is often referred to as "dopamine: the neurotransmitter against all our problems," because everyone knows how a drug-triggered dopamine rush feels, and if this could hold on forever, we would fix all of our problems because nothing would make us sad.

(Small fact: dopamine is actually a neurotransmitter and not a hormone. There are differences between those two, but I won't explain that now because this text is already long enough.)

Hope you liked the small facts too, and thanks to everyone who wrote it in its entirety.

EDIT: its now 12:31, meaning this took almost 40 minutes, yikes

 

[ShulginsReincarnation]

First things first: I wish everyone a very beautiful morning or early noon (im living in the timezone UTC/GMT+1, meaning its currently 11:57am for me)

When you like Diazepam this much, then I can recommend you "Nordazepam," also known as nordiazepam, desoxydemoxepam, and desmethyldiazepam. It's like Diclazepam, an active metabolite of Diazepam, and is considered the benzodiazepine with the longest half-life currently known: 40 - 200 hours.

It's primarily used as an anxiolytic drug, meaning it's used against panic and anxiety disorders, but it also has amnesic, anticonvulsant, muscle relaxant, and sedative effects (from strongest to weakest). In my opinion, it has many similarities to Diazepam but is overall weaker. Some brand names are: Nordaz, Stilny, Madar, and Vegesan.

Overall, 10mg of Nordazepam equals 5 - 6mg of Diazepam, meaning it's way weaker than Diclazepam and is basically (in my opinion) on the level of Oxazepam (Adumbran) and Chlordiazepoxide (Librium). I'm not a fan of Alprazolam nor Lorazepam. The only good "anxiolytic" benzo is "Bromazepam/Bromazanil" because it doesn't make me as emotionless, dysphoric, dead inside, and tired. Nordazepam is on the same level as Bromazepam and Diazepam for me, meaning I would give it a 3.5/5 in total, but considering your taste, you should definitely check it out.

Recommendations: Bromazepam and Nordazepam

@Esperighanto, thank you for explaining the differences in such a short and nice compact text. I'm truly impressed that you knew this difference too. I only found out about this fact 2 months ago in my university. That was actually one of the first topics in my medicine study, and I must say that I love it. I mean, in general, getting more and more knowledge about how the body works, how medication, plants, etc., actually work and why they do the things they do. The entire history, from shock therapy to barbiturates to methaqualone and now the benzodiazepines. I also got the feeling that gabapentinoids, especially Lyrica, are slowly replacing some of the benzodiazepines, which I can understand in some way.

Only because of the small fact that I agreed to take a drug this one day, it evolved all the way up to a fascination with medicine and especially neuroscience. It still amazes me how 2mg of a powder, a tiny pellet, can change your mood from the most depressed to the happiest in just a couple of minutes. That's also why transmitters like serotonin, dopamine, norepinephrine, oxytocin, etc., are called "the rulers of this world," because they decide how we feel and how we act. That's also why dopamine is often referred to as "dopamine: the neurotransmitter against all our problems," because everyone knows how a drug-triggered dopamine rush feels, and if this could hold on forever, we would fix all of our problems because nothing would make us sad.

(Small fact: dopamine is actually a neurotransmitter and not a hormone. There are differences between those two, but I won't explain that now because this text is already long enough.)

Hope you liked the small facts too, and thanks to everyone who wrote it in its entirety.

EDIT: its now 12:31, meaning this took almost 40 minutes, yikes

Well, thank you for writing all of this and for your statement about Eve & Rave before. I do not know German yet, but it was on my list of languages to tackle anyway so this will give me more motivation to learn it.

Anyway, also, your explanation of how you came to be interested in the medical science aspect of things matches my own experience very much. I think this is why you stood out to me more than many other users so far; we think the same way. Also, there is the fact that Northern Europe is very familiar to me as well, but that's a topic for another time haha

Thanks again for sharing though; I hope to continue to learn from what you have to share as you are very insightful. Peace.

 

[canadianpeduser]

Diclazepam (2-Chloro Diazepam) is a great compound, actually synthesized by the same polish chemist who made Diazepam (Valium), Klonopin and Librium.

Diclazepam 1mg metabolism into 3 legitimate benzodiazepines......the most significant being Delorazepam 78h half life, then finally into Lorazepam (Ativan).

Diclazepam is like the Methadone of benzodiazepines and is longer acting that Valium

Chlorodesmethyldiazepam (Delorazepam) is prescribed in Italy as a long acting anxiolytic benzodiazepine which then metabizes into Lorazepam (Ativan)

Diclazepam isn't very pleasurable or enjoyable but it's a very potent & long acting anxiolytic benzodiazepine. I bought over 1,500mg of Diclazepam and still have a healthy inventory. 2-3mg is a very robust dose and you'll be tranquilized for several days of anxiety free relaxation. A single mg is sufficient but 2mg is best . 2-3 actually

Avizafone (Pro-Diazepam) is also great. I purchased several grams ....oral administration is ok but wasn't getting that real Valium feel .....so I took Avizafone 50mg and SC injection under skin pinched stomach and pocked needle in to bypass first pass metabolism and in 5 to 10 min I was feeling great

Avizafone 22.5mg
Diazepam 10mg ....if I remember correctly

Shit I literally am in a Canada and I still can’t get my hands on avizafone! Had to pay up the ass to get some actual diazepam and of course due to the yearly Christmas postal strike im still waiting an extra week for that to get here..

Btw @Dextro .45 ; would you mind kindly mentioning how similar avizafone dependency and withdrawals would be like compared to just taking actual diazepam ?

 

[Mana0909]

Well, thank you for writing all of this and for your statement about Eve & Rave before. I do not know German yet, but it was on my list of languages to tackle anyway so this will give me more motivation to learn it.

Anyway, also, your explanation of how you came to be interested in the medical science aspect of things matches my own experience very much. I think this is why you stood out to me more than many other users so far; we think the same way. Also, there is the fact that Northern Europe is very familiar to me as well, but that's a topic for another time haha

Thanks again for sharing though; I hope to continue to learn from what you have to share as you are very insightful. Peace.

Normally, I am a very confident, self-aware, and direct person, you know? In other words, when I don't like someone online, I just block them without a warning because they are just strangers to me. The same goes for compliments—when they come from strangers, I also don't really care. I have a big circle of people who love and appreciate me, but hearing from someone who doesn't know me personally that I stood out because of my knowledge, personality, and experience is making me smile.

Thank you very much for thinking so highly of me. I'm also happy that we share the same fascination with psychoactive substances and how they change our perspective, enhance or decrease our mood, relieve or cause stress, etc.

I only wish you the best for your own journey, and I hope that you achieve all the goals you set in your life.

 

[Esperighanto]

I'll be somewhat intermittent for a couple weeks, moving to an area that will allow me to grow a ton of interesting plants. Trying to have germinated a hundred cacti within a month from now. Really trying to figure out how to grow lotus flowers that also bind to the benzodiazepine receptor in a poorly understood manner.

@Mana0909, Hormones, small molecules (including neurotransmitters), cytokines iirc?, and I thought one or two other things exist at that scale of existence, yeah? It's been a while since I thought about hormonal circuits until I was trying to figure out why smoking cannabis helped my asthma, turns out it's anti-inflammatory likely due to inducing some form of positive allosteric modulation of a hormone called COX10. Objectively a critical part of its pharmacology and it doesn't even touch upon neurotransmitters. I wish more people were aware of things like that, or GHB being a human growth hormone PAM. I started seeing much higher gains as as powerlifter when I was in college when GHB was more common than not in my life.

On the topic of the thread, to these prodrugs have a delayed onset and/or come-up time compared to their targeted metabolite, and are there any other metabolites? I'd assume so, but there's very little in the way of consistent reports, or many reports at all it seems for many of the benzo prodrugs.

 

[ShulginsReincarnation]

It's been a while since I thought about hormonal circuits until I was trying to figure out why smoking cannabis helped my asthma, turns out it's anti-inflammatory likely due to inducing some form of positive allosteric modulation of a hormone called COX10. Objectively a critical part of its pharmacology and it doesn't even touch upon neurotransmitters. I wish more people were aware of things like that, or GHB being a human growth hormone PAM. I started seeing much higher gains as as powerlifter when I was in college when GHB was more common than not in my life.

Glad you have come to these realizations, and GHB was actually initially sold in the 1980s as a body building drug before becoming illegal due to date rape cases involving it rising rapidly... Sad...

But, yes, I feel a lot of the stuff regarding drugs and their effects on hormones is very under discussed too.

On the topic of the thread, to these prodrugs have a delayed onset and/or come-up time compared to their targeted metabolite, and are there any other metabolites? I'd assume so, but there's very little in the way of consistent reports, or many reports at all it seems for many of the benzo prodrugs.

There would be the metabolite of the linker moeity from the clevage of such from the parent compound which may then have more secondary metabolites, but I have only limited knowledge of such aspects of pharmacology. This is something I am learning more in depth now myself.

I do not know many additional details for Tmax as you ask, but there would likely be some sort of delay as it is with lisdexamfetamine preparations (this results in lysine as a metabolic byproduct of course.)


...
Did not mean to intrude on the conversation, but did want to at least shine some light on these things for you as I was checking for updates on the threads I have been involved in just now and I have some extra time.

 

[Esperighanto]

Glad you have come to these realizations, and GHB was actually initially sold in the 1980s as a body building drug before becoming illegal due to date rape cases involving it rising rapidly... Sad...

This is also quite wild to me, the dosage range between incapacitation and death is shockingly low with GHB compared to other things like benzos. I suspect it's just too difficult to hide the bitter taste of benzos.

I'm also curious about possibly novel pharmacodynamics that may come from these prodrugs. Soma as a prodrug for carisoprodol, for example, adds an adenosine reuptake inhibition iirc.

 

[ShulginsReincarnation]

I'm also curious about possibly novel pharmacodynamics that may come from these prodrugs. Soma as a prodrug for carisoprodol, for example, adds an adenosine reuptake inhibition iirc.

Mm, Carisporodol is Soma's generic name. Carisprodol is not necessarily a pro-drug per se, but it is the parent drug of a metabolite known as Miltown as a brand name and generic is Meprobamate which has greater efficacy I do believe. Its been a while since studying that one to any extent.

I just remember it mainly as the drug I ate about 12 tablets from 1986 back in the mid 2000s that I found in my friend's Father's medicine cabnet during school one day, and I ended up feeling mdma like euphoria lol. That was a good day, but it took too many to get an effect like that and so I only got one good buzz, and the rest of them I spaced out to maintain it the rest the day haha. Ahh, to be young again lol

 

[Esperighanto]

Mm, Carisporodol is Soma's generic name. Carisprodol is not necessarily a pro-drug per se, but it is the parent drug of a metabolite known as Miltown as a brand name and generic is Meprobamate which has greater efficacy I do believe. Its been a while since studying that one to any extent.

I just remember it mainly as the drug I ate about 12 tablets from 1986 back in the mid 2000s that I found in my friend's Father's medicine cabnet during school one day, and I ended up feeling mdma like euphoria lol. That was a good day, but it took too many to get an effect like that and so I only got one good buzz, and the rest of them I spaced out to maintain it the rest the day haha. Ahh, to be young again lol

I'm detrimentally geeked off of Soma rn, forgetting that it doesn't turn from a brand name into a generic but from cari into a carbamate hahaha. My apologies about that.

It's definitely an insanely fascinating drug, they've been gaining a lot of popularity on and off over the decades it seems. The MDMA like euphoria remains as long as I give it a couple days between uses, and the potentiation of LSD with carisoprodol is highly underexplored it seems. Psilacetin and miprocin were also potentiated, but 2C-B, allylescaline, MDA, MDMA, and amphetamine all were not. This seems to indicate that the indole core of tryptamines/lysergamides is key to this potentiation, but frankly I've not a clue as to why and I can't find anybody else talking about this phenomenon.

Edit: What tolerance initially forms can become a reverse tolerance with time I've noticed, with only a sample size of three people I've seen that Soma will get weaker for a few days after regular use, then we end up needing less and less and less until taking any at all will give us the shakes. I'm suspecting there may be some sort of long lasting metabolite accumulating? I'll need to hit the literature when I'm less intoxicated from Soma.

 

[ShulginsReincarnation]

I'm detrimentally geeked off of Soma rn, forgetting that it doesn't turn from a brand name into a generic but from cari into a carbamate hahaha. My apologies about that.

It's definitely an insanely fascinating drug, they've been gaining a lot of popularity on and off over the decades it seems. The MDMA like euphoria remains as long as I give it a couple days between uses, and the potentiation of LSD with carisoprodol is highly underexplored it seems. Psilacetin and miprocin were also potentiated, but 2C-B, allylescaline, MDA, MDMA, and amphetamine all were not. This seems to indicate that the indole core of tryptamines/lysergamides is key to this potentiation, but frankly I've not a clue as to why and I can't find anybody else talking about this phenomenon.

Edit: What tolerance initially forms can become a reverse tolerance with time I've noticed, with only a sample size of three people I've seen that Soma will get weaker for a few days after regular use, then we end up needing less and less and less until taking any at all will give us the shakes. I'm suspecting there may be some sort of long lasting metabolite accumulating? I'll need to hit the literature when I'm less intoxicated from Soma.

Very interesting... Yes, I will have to read up more on the phenomenon you describe as well. I appreciate your insights.