☮ Social ☮ PD Social Tripping Thread: aLL aBoArD tHe MoThErShiP 👽🛸
- Thread starter Kaleida
- Start date
Kaleida
Bluelight Crew
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How was your trip?
ions
Mr. Fantasy
In tribute to cosmic Charlie I’m posting to report having taken some mushies. Gotta work on a fresh character for thanksgiving dinner. And declare the Wednesday b4 thanksgiving hatesgiving. So happy hatesgiving. Bitches
marley dope kid
Ex-Bluelighter
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- Nov 22, 2023
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im $orry about heroine
i wanTed 2 $av uz
im gOOd
i wanTed 2 $av uz
im gOOd
Hard for me to think of hate when peaking on mushies or LSD ...
Different strokes for different folks I suppose
Meanwhile, in an alternate universe :
ions
Mr. Fantasy
Like I hate Taylor swift and the rock for stealing money from homegrown. And I think of ways of getting my money back.
marley dope kid
Ex-Bluelighter
- Joined
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If these guys are doing his off while peaking on mushies, LSD or anything like that they have my deepest respect
ions
Mr. Fantasy
Judge not lest ye be judged
Um, who''s judging, LOL ...
Tripping and pulling moves like that are heroic
But, um ... who's judging ?
ions
Mr. Fantasy
I saw the word guilty. Figured somebody passing judgement. But here’s the catch. I ain’t judgin’
ions
Mr. Fantasy
I do accuse you @Cheshire_Kat of having a hard on to prove me wrong.
I accuse you of being stoned.
but then, everyone MUST get stoned
but then, everyone MUST get stoned
ions
Mr. Fantasy
Hence the hatesgiving holiday.
:hai:
:hai:
Love ya dude, have fun !
Deleted member 521610
Bluelighter
gonna go on a heavy journey tomorrow. To try find the joy in life again, and the love of the divine.
Pfafffed
Bluelight Crew
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Really want to do that myself. Unfortunately, I need to stay lucid for the next little while. I have family and friends that are likely to have some heavy stuff to process (loved ones in hospice age such,) so I want to be ready to be present for them if they need me.
But soon. It's been too long, maybe fifteen years since I last ate mushrooms.
Deleted member 521610
Bluelighter
fifteen years is a very long time. I hope everything works out for you and when you have the special time with no worries you get to enjoy a great trip.
I have decided to not dose myself the full 440 ug tonight. In a couple hours I will dose myself with around 300-330 ug of acid. Still super strong. But I just felt like 440 ug was too much, 300 ug will have me transcending space and time and on a heavy trip as it is.
At 300 ug I can still break out of the loops if i get caught in one, at 440 ug a bad thought could have me trapped for a few hours. gonna create a playlist to setup
Deleted member 521610
Bluelighter
Glad i only 330 ug, Lived a lifetime, Had my entire life flash before my eyes, all the pain, so much pain, infact most of the trip spent trying to unpack all the pain and unraveled many things.
It put me on my ass, and humbled me with the hand of god.
I realize that drugs and tripping won't heal the other broken parts of my psyche and that i need to finally go seek therapy to heal and let go of negativity and accept life as it is.
I pretty sure I went through various stages of transpersonal psychlogology described by stanislov grof, i was grinded through a womb and experinced the pain of birth, and witnessed my life and reviewed it.
as the peak hit, and my ego dissolved and i had a very powerful encounter with the divine.
discovered some legendary beats in the process aswell.
But, yeah I won't be tripping again EVER. Thats me done. It was fucking hell of a ride!!!!
But, I gained the insights into my own mind. Instead of tryna to frakenstein put my psyche back together into one piece as i have been for the years and years, I decided its best to see a professional.
It put me on my ass, and humbled me with the hand of god.
I realize that drugs and tripping won't heal the other broken parts of my psyche and that i need to finally go seek therapy to heal and let go of negativity and accept life as it is.
I pretty sure I went through various stages of transpersonal psychlogology described by stanislov grof, i was grinded through a womb and experinced the pain of birth, and witnessed my life and reviewed it.
as the peak hit, and my ego dissolved and i had a very powerful encounter with the divine.
discovered some legendary beats in the process aswell.
But, yeah I won't be tripping again EVER. Thats me done. It was fucking hell of a ride!!!!
But, I gained the insights into my own mind. Instead of tryna to frakenstein put my psyche back together into one piece as i have been for the years and years, I decided its best to see a professional.
Kaleida
Bluelight Crew
- Joined
- Sep 6, 2015
- Messages
- 2,806
Holy moly, nuciferine is a 5-HT2A receptor agonist. This is not a drill, people; I repeat: this is not a drill.
Nuciferine is thought to be the primary active alkaloid from blue lotus, Nymphaea caerulea, as well as the similar plant, Nelumbo nucifera. They each contain multiple aporphine alkaloids, a group that contains nuciferine.
Aporphine alkaloids have long been treated as antagonists of monoamine receptors, including ones for serotonin, dopamine, and norepinephrine. There are many aporphine alkaloids have been studied and they usually have effects like this in scientific studies, being able to block the effects of strong monoaminergic agonists, including nuciferine itself blocking the 5-HT2A receptor-mediated effects of DOI.
However, there is some evidence that aporphine alkaloids can have agonistic effects on monoamine receptors as well. For instance, nuciferine itself in at least one study appeared to function as a D2 receptor partial agonist, and glaucine is a popular fringe recreational drug these days that is an aporphine alkaloid extracted from yellow poppy and is known to produce some odd tranquilizer-like effects alongside some notably psychedelic visuals and perhaps headspace changes, and it has been shown in scientific studies to be a partial agonist at all three 5-HT2 receptors.
Sometimes, when a drug appears to have an antagonistic effect at some receptor, it turns out that that drug is actually just a very weak partial agonist. Partial agonism allows a drug to behave like both an agonist and an antagonist depending on the context due to their very low efficacy at activating a given receptor, but also with that efficacy still being non-zero. For this reason, if the receptors they are binding to are completely free and they're not competing with any other molecules, they'll have an agonistic effect and increase activity compared to when they weren't present, but if they have to compete for receptor binding with full agonists or other agonists with higher affinity than themselves, they will cause a functional antagonism and a lowering of activity compared to before they were present.
In the study I linked above where nuciferine was found to act as a D2 receptor partial agonist, it was also found to be a 5-HT2A receptor antagonist. However, it appears that the way they "verified" this activity was by testing its ability to antagonize the behavioral effects of DOI. Again, it would be expected that it would do this if it was an antagonist, but it could also occur if it was simply a lower efficacy partial agonist compared to DOI, which generally seems to be of higher efficacy. Interestingly, this study also showed that nuciferine substituted in animal discrimination studies for clozapine, an atypical antipsychotic which is often said to have 5-HT2A receptor antagonist activities, but has also more recently been shown to be a functionally-selective 5-HT2A receptor agonist.
Now, a new study from this year has claimed that nuciferine, as well as several other aporphine alkaloids from Nelumbo nucifera, is actually an agonist at 5-HT2A and 5-HT2C receptors, and that nuciferine is the most potent 5-HT2A receptor agonist of the tested molecules. The study is in Chinese, but I ran it through a translator, and for the record, nuciferine is compound 9. Here is an excerpt from the translation.
Interestingly, blue lotus is one of those drugs that is often written to have hallucinogenic effects in scientific articles and medical journals and such even though most users of it seem to disagree. I think most people who have used blue lotus would agree that even in the times when it can get slightly trippy, it's not a very powerful psychedelic or anything like that. That being said, it is not uncommon for people to claim that they have had things like visual effects from it. For example, here's a few posts from a Reddit thread I found easily.
Personally, anecdotally, I have also gotten psychedelic visuals from blue lotus, although I have only noticed them outside while at nighttime. I also wondered if HPPD played a role, but I still remember them standing out. I was staring at some trees in my backyard during the only memory of it I still vividly recall, watching light but clear and colorful geometric patterns moving around on the shadowy tree branches and leaves, but that was the extent of what I saw. This was from smoking it. I have also noticed effects from blue lotus that I considered to be trippy although not necessarily definitely reminiscent of psychedelics, but I did have a hard time connecting them to just its supposed antipsychotic-like activity; these included things like an almost psychedelically peaceful clarity of mind and silence in my headspace, just enjoying my surroundings and taking things in like while on a trip; smoking lots of blue lotus with a friend to the point that we were laughing a lot similar to a good cannabis high as I compared it to at the time, but notably also not unlike on a psychedelic; and I've also gotten some pro-sexual effects from blue lotus which I've talked about here on this forum before (although not in this thread specifically I don't think) where my nipples became highly sensitive, to a degree that I usually don't get stimulated from basically anything from except for select psychedelics like LSD, which notably also acts not only on serotonin receptors but also those for dopamine and norepinephrine, even specifically being known to be a relatively lower efficacy partial agonist of 5-HT2A receptors and D2 receptors.
Coincidentally, before reading all of this, like a week or so ago I think, I bought some blue lotus extract capsules for the first time ever, supposedly a 100:1 extract. I still not tried taking them yet, as I was waiting for a good time to give it a go. After reading this tonight, I decided to take one just before dinner, as of typing this sentence exactly 50 minutes ago. I have no idea what strength to expect it to be and am uncertain how taking it orally will compare to smoking it, as I'd expect there could be differences in metabolism and stuff like that.
So far? I have to say, it gave me a good comeup feeling at the beginning of my typing this post, although it seems to have settled into the background a little bit more. Honestly, I do think it feels not unlike a psychedelic body feeling, all things considered. I also got what I would consider to be genuinely seemingly psychedelic-like visual flashes in my mind's eye similar to coming up on a known psychedelic, although juuuuuust barely, and just flashes, so lightly that I have to wonder if it was placebo, but also notably enough that I'm not convinced that it definitely was just placebo. I think the capsules seem decently potent so far, given that it's my first time ever taking it orally, and I'm interested to see if it continues to develop from this point on, although I won't be taking any more tonight for sure.
In the past, smoking blue lotus during the day has seemed to make me kind of tired, whereas smoking it at night has seemed to keep me awake. This also seems possibly worth noting as I'm starting to wonder if higher concentrations of serotonin and dopamine earlier in the day cause the nuciferine and other aporphine alkaloids to have an antagonistic effect, while taking them at night with lower levels of those neurotransmitters could allow them to be more agonistic....
Anyway, that's what I've got to say so far. I wanted to share the news and also give my experiment updates so far. I'll add more notes if there's more interesting to say about this capsule, although there may not be much more for tonight. But I have to say I'm certainly more interested in experimenting with these blue lotus extract capsules now than I already was before and intend to continue posting about my further experiments here as well.
Hope everyone here is doing well!
Nuciferine is thought to be the primary active alkaloid from blue lotus, Nymphaea caerulea, as well as the similar plant, Nelumbo nucifera. They each contain multiple aporphine alkaloids, a group that contains nuciferine.
Aporphine alkaloids have long been treated as antagonists of monoamine receptors, including ones for serotonin, dopamine, and norepinephrine. There are many aporphine alkaloids have been studied and they usually have effects like this in scientific studies, being able to block the effects of strong monoaminergic agonists, including nuciferine itself blocking the 5-HT2A receptor-mediated effects of DOI.
However, there is some evidence that aporphine alkaloids can have agonistic effects on monoamine receptors as well. For instance, nuciferine itself in at least one study appeared to function as a D2 receptor partial agonist, and glaucine is a popular fringe recreational drug these days that is an aporphine alkaloid extracted from yellow poppy and is known to produce some odd tranquilizer-like effects alongside some notably psychedelic visuals and perhaps headspace changes, and it has been shown in scientific studies to be a partial agonist at all three 5-HT2 receptors.
Sometimes, when a drug appears to have an antagonistic effect at some receptor, it turns out that that drug is actually just a very weak partial agonist. Partial agonism allows a drug to behave like both an agonist and an antagonist depending on the context due to their very low efficacy at activating a given receptor, but also with that efficacy still being non-zero. For this reason, if the receptors they are binding to are completely free and they're not competing with any other molecules, they'll have an agonistic effect and increase activity compared to when they weren't present, but if they have to compete for receptor binding with full agonists or other agonists with higher affinity than themselves, they will cause a functional antagonism and a lowering of activity compared to before they were present.
In the study I linked above where nuciferine was found to act as a D2 receptor partial agonist, it was also found to be a 5-HT2A receptor antagonist. However, it appears that the way they "verified" this activity was by testing its ability to antagonize the behavioral effects of DOI. Again, it would be expected that it would do this if it was an antagonist, but it could also occur if it was simply a lower efficacy partial agonist compared to DOI, which generally seems to be of higher efficacy. Interestingly, this study also showed that nuciferine substituted in animal discrimination studies for clozapine, an atypical antipsychotic which is often said to have 5-HT2A receptor antagonist activities, but has also more recently been shown to be a functionally-selective 5-HT2A receptor agonist.
Now, a new study from this year has claimed that nuciferine, as well as several other aporphine alkaloids from Nelumbo nucifera, is actually an agonist at 5-HT2A and 5-HT2C receptors, and that nuciferine is the most potent 5-HT2A receptor agonist of the tested molecules. The study is in Chinese, but I ran it through a translator, and for the record, nuciferine is compound 9. Here is an excerpt from the translation.
Alkaloids from leaves of Nelumbo nucifera Gaertn and their agonistic activities on 5-HT2A and 5-HT2C receptors said:
Interestingly, blue lotus is one of those drugs that is often written to have hallucinogenic effects in scientific articles and medical journals and such even though most users of it seem to disagree. I think most people who have used blue lotus would agree that even in the times when it can get slightly trippy, it's not a very powerful psychedelic or anything like that. That being said, it is not uncommon for people to claim that they have had things like visual effects from it. For example, here's a few posts from a Reddit thread I found easily.
Personally, anecdotally, I have also gotten psychedelic visuals from blue lotus, although I have only noticed them outside while at nighttime. I also wondered if HPPD played a role, but I still remember them standing out. I was staring at some trees in my backyard during the only memory of it I still vividly recall, watching light but clear and colorful geometric patterns moving around on the shadowy tree branches and leaves, but that was the extent of what I saw. This was from smoking it. I have also noticed effects from blue lotus that I considered to be trippy although not necessarily definitely reminiscent of psychedelics, but I did have a hard time connecting them to just its supposed antipsychotic-like activity; these included things like an almost psychedelically peaceful clarity of mind and silence in my headspace, just enjoying my surroundings and taking things in like while on a trip; smoking lots of blue lotus with a friend to the point that we were laughing a lot similar to a good cannabis high as I compared it to at the time, but notably also not unlike on a psychedelic; and I've also gotten some pro-sexual effects from blue lotus which I've talked about here on this forum before (although not in this thread specifically I don't think) where my nipples became highly sensitive, to a degree that I usually don't get stimulated from basically anything from except for select psychedelics like LSD, which notably also acts not only on serotonin receptors but also those for dopamine and norepinephrine, even specifically being known to be a relatively lower efficacy partial agonist of 5-HT2A receptors and D2 receptors.
Coincidentally, before reading all of this, like a week or so ago I think, I bought some blue lotus extract capsules for the first time ever, supposedly a 100:1 extract. I still not tried taking them yet, as I was waiting for a good time to give it a go. After reading this tonight, I decided to take one just before dinner, as of typing this sentence exactly 50 minutes ago. I have no idea what strength to expect it to be and am uncertain how taking it orally will compare to smoking it, as I'd expect there could be differences in metabolism and stuff like that.
So far? I have to say, it gave me a good comeup feeling at the beginning of my typing this post, although it seems to have settled into the background a little bit more. Honestly, I do think it feels not unlike a psychedelic body feeling, all things considered. I also got what I would consider to be genuinely seemingly psychedelic-like visual flashes in my mind's eye similar to coming up on a known psychedelic, although juuuuuust barely, and just flashes, so lightly that I have to wonder if it was placebo, but also notably enough that I'm not convinced that it definitely was just placebo. I think the capsules seem decently potent so far, given that it's my first time ever taking it orally, and I'm interested to see if it continues to develop from this point on, although I won't be taking any more tonight for sure.
In the past, smoking blue lotus during the day has seemed to make me kind of tired, whereas smoking it at night has seemed to keep me awake. This also seems possibly worth noting as I'm starting to wonder if higher concentrations of serotonin and dopamine earlier in the day cause the nuciferine and other aporphine alkaloids to have an antagonistic effect, while taking them at night with lower levels of those neurotransmitters could allow them to be more agonistic....
Anyway, that's what I've got to say so far. I wanted to share the news and also give my experiment updates so far. I'll add more notes if there's more interesting to say about this capsule, although there may not be much more for tonight. But I have to say I'm certainly more interested in experimenting with these blue lotus extract capsules now than I already was before and intend to continue posting about my further experiments here as well.
Hope everyone here is doing well!