Mental Health Coming off Invega (Paliperidone, Xeplion) injections v 6.0

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I’m 5 months & 1 day off of Invega so far, and it’s been rough. I still have all the Anhedonia, & akathisia is a little less severe, but still pretty bad. Cognitively I think I’m a little better, but still have a long way to go, I can now actually keep up with and understand TV shows and movies, but i still don’t get any pleasure out of watching, just something to pass the time and distract myself with. I still have trouble communicating and thinking of things to say.

I’m sure some of you will be glad to hear this, at 5 months off, I get high from smoking regular weed (not taking 2000 mg in edibles like before) and alcohol works as well. Shitty part is I still feel terrible while drunk/high, and getting high has been making my anxiety go crazy.

One last thing that I haven’t seen anyone mention, I HURT so fucking bad, all the time, all over, no matter if I take Ibuprofen or Tylenol, it’s in my muscles and my joints. It’s gotten really bad over these past couple of weeks and now I feel like a chronic pain patient in addition to the Invega. Has anyone else had this?
Yeah bro in my first month off I had chronic back pain it went away though.
 
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Last time I had invega was in January or February. I then was on haldol until May and been on abilify ever since. I was hoping the abilify would make me hypersexual but it didn't. I can get an erection on abilify just not as easily as before, on invega I couldn't at all. On abilify my semen has also got better. I'm thinking about stopping smoking cigarettes to see if it helps bring back my sensitivity because I heard smoking causes issues down there. My mums nurse also said her patients never complained about sexual side effect of abilify so assumes everythings fine. My life would be perfect if I had high sensitivity in my penis like I did before, even if it's harder to get a boner. I'd rather be able to feel pleasure and have a boner not as easily, than having a boner and not feeling pleasure at all.
 
Same bro. Only problem I have is I get random muscle twitches and my feet or fingers will jerk. TD mostly.but it's very mild and truly don't care I have it
@Bigsmoke420 can you feel adrenaline/HIGH levels of excitement from music or winning at games pre-Invega or is it kinda flat, endorphins from workouts and laugh until your side hurts, and be bubbly/giggly? Also are you able to have multiple thoughts where your mind is back normal? I used to have like 5-6 thoughts at a time. Now I just have 0-2 thoughts at a time with some mind blankness. Lastly, do you currently take any other meds?
 
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Thank you for sharing your sketches. I can’t really notice a difference between the sketches just before and after Invega, they both look great to me. But I do notice that your most recent sketches are a bit off. I agree though that as long as the motivation is back, you can put in the practice required to get back your skills. All the best!
The last sketches were from life. Maybe I'll do some from photograph like the former sketches to get a true somparison of my abilities
I’ve always wanted to try ecstasy, but I have no idea where to get these drugs. Someone recommended hydrocodone to relieve anhedonia from the poison sustenna, but I’m sure a doc wouldn’t prescribe that easily. I really could use some relief at this point. I’ve been so patient but this has been so difficult.
I've heard that you can't get ecstasy anymore and it's all just fentanyl
Your posts are too long to read for my post-invega brain, sorry pal lol
My ability to focus and read is fully recovered and I also skip his posts
Neither for me. I'm at the 11 month mark (off of paliperidone). My psychiatrist kept me on paliperidone for a whole extra month even after my syndrome (side effects) emerged, so I've been experiencing these things for 12 months, while being 11 months off paliperidone.


Yep, I had that same experience at the 4 month mark. And at the 11 month mark, I too, am still as impotent as day 1, sadlol.


First off, those are really impressive numbers. Your bench is out of control good. Since squat and deadlift in a balanced body are supposed to be significantly higher than bench, I think your squat and deadlift ceiling is way higher than that.

You guys have the right ideas and ask the right questions. Measures like continuing to work out and nofap are very wise and should, by conventional wisdom, work. However, I just wanted to share, for anyone who cares, that exercise and nofap has not worked for me at all. I do, admittedly, have a severe form of this paliperidone syndrome. Seems like the metabolism and the fish downstairs are totally dead, lol.


Hormone and blood tests--the right ideas and the right questions. I did want to share that at just 1-2 months off paliperidone, I, also, did a prolactin and testosterone test. My levels were normal (much to my disappointment, hoping for a smoking gun leading to a direct cure). Whether my prolactin and testosterone levels were not affected at all by paliperidone or whether they leveled off right away, either way, in my situation, it seems to suggest that these terrible adverse side effects/symptoms can persist and exist in spite of normal prolactin and testosterone levels. Abnormal hormones have been implicated in the "man-boobs" problem (Gynecomastia) and in some forms of sexual dysfunction, low libido, sexual anhedonia. However, if my case is any indication, it may be that paliperidone achieves all these horrible life-devastating effects by some other mechanism or pathway we don't understand.
Do you have a full list of meds you've taken/are taking? Were regular benzos on there somewhere?
When did everyone’s inner dialogue return?
Beginning around 13 months
@iridescentblack haven’t you been off for a while?
He's on other APs.
I can’t hold a conversation to save my life. Does anyone know when that comes back?
Around 13-14 months you'll be able to practice speaking again.
 
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I’m about eight pounds overweight right now, but I’m on a small dose of APs so I guess it’s not that bad. Still very annoying though! Wish I could lose the last eight pounds!!!!
 
Anyone able to laugh, joke and be as bubbly as before or is everyone just kinda ‘content’ now? Also does anyone sleep in 2-3 increments now since the shot?
 
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Anyone able to laugh, joke and be as bubbly as before or is everyone just kinda ‘content’ now? Also does anyone sleep in 2-3 increments now since the shot?
No laugh in ages. Only in dreams sometimes
 
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Day 92:

Restlessness has eased up majorly. I get what they say most improvements happen from month 3-4. Can actually feel my brain. Blank mind is starting to ease up. Enjoy brushing my teeth and using deodorant again. Still suffer from being bored. Hopefully I can be one who heals in 7 months. Good luck everyone. Healing is definitely possible!
 
Day 92:

Restlessness has eased up majorly. I get what they say most improvements happen from month 3-4. Can actually feel my brain. Blank mind is starting to ease up. Enjoy brushing my teeth and using deodorant again. Still suffer from being bored. Hopefully I can be one who heals in 7 months. Good luck everyone. Healing is definitely possible!
I get what you say about being bored, that's my main struggle right now.
I lost my patience for things I used to love doing, everything is boring.
 
However, you mentioned norepinephrine, and that peaks my interest. I have considered the importance of norepinephrine while slightly dismissing it. Particularly, I personally did not come across evidence for its strong role in sexual function, but I might have misread/not read enough and am going to do more reading.

NE is strongly associated with libido. It's kinda painted as the 'driving' or 'motivating' push factor in sexual interest, as it is more generally in motivation and in overcoming depression. For some people (like myself) anxiety, stress and panic can actually cause a powerful kick to libido. There have been times I've luckily been able to flip instantaneously like a switch from full blown panic attack into almost unbearable sexual desire just by looking at something that would normally turn me on when it starts.

Dopamine doesn't really seem to be tied into libido in quite the same - it's more about transforming that sexual interest into a habit that can in turn be stimulated with increasing potency in future through a number of associated simuli that get pulled into the sexual moment and packaged together (via enhanced neural connectivity). And which then prompts its own flood of motivating NE under conditions associated to the forming habit in a self-reinforcing cycle. Much like an addiction.

Of course, DA and NE can also interact at each other's receptors in certain parts of the brain and under certain conditions, there are loads of subtypes, and undoubtedly the incredibly and overwhelmingly complex assortment of simultaneous pre and post synaptic actions of everything come into play too. But for sure, there's a big role played by adrenergic stimulation.
 
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