Corynanthe johimbe - ingredients and uses.

[izo]

last profile, for now:

Corynanthe johimbe - Wikipedia

en.wikipedia.org

aphordisiac.

alkaloids on wiki:

Yohimbine - Wikipedia

en.wikipedia.org

Corynanthine - Wikipedia

en.wikipedia.org

Ajmalicine - Wikipedia

en.wikipedia.org

tried the extract last year, since it was a whole plant extract there was no effect. the shredded root bark tested almost 20 years ago was nice though, slightly halucinogenic. pure yohimbine is often described as anxiogenic.

 

[izo]

rätsch:

drug
Bark (Cortex Yohimbe, Yohimbe cortex, Yohimbehe cortex, yohimbe bark, yohimbeherinde, potency bark)
The raw drug is presumably absorbed by the bark of other Pcirisirrysttilici species and Corynanthe spp. falsified:
"By the way, it's interesting
that the natives of the French Congo used the bark of a tree as an aphrodisiac,
whom they called "Endun" and which Pierre called "Pausinystalia Trillesii". This bark also contains yohimbine; the tree itself
probably belongs to the genus Corynanthe.« (HIRSCHFELD and LINSERT 1930: 172)

 

[izo]

preparation and dosage
Only the dried bark is used. It can be extracted with alcohol (tincture) or prepared as a tea (cf.
SPEED 1996: 1460.
For a tea, six teaspoons of yohimbe bark per person with 500 mg of vitamin C are boiled for 10 minutes and then
drunk in sips (according to GOTTLIEB 1974: 76*, MILLER 1988: 1430.
A »strong sexual enhancer« is prepared from the following ingredients (according to GOTTLIEB 1974: 81*):
1 teaspoon yohimbe bark (Cortex Yohimbe)
1/2 teaspoon dita seeds (Alstonia scholaris), crushed
1 teaspoon kola nuts (Cola spp.), broken up
1 teaspoon sarsaparilla bark (Stnilax spp.)
The ingredients are boiled in water for 10 minutes and sipped as a decoction.
Yohimbe extracts are used in the pharmaceutical industry to produce aphrodisiacs or medicines
Treatment of impotence used. They are treated with atropine, Turnera diffusa, Strychnos nux-vomica, Strychnos spp.,
Liriosma ovata and others
combined.
The bark is also used in aphrodisiac smoking mixtures (BROWN and MALONE 1978: 20*). Served in West Africa
or serves as an additive to iboga (see Tabernanthe iboga).
A DOSE of 10 drops of a 1% solution is mentioned as a “stimulant for the sexual organs” (BOERICKE 1992: 8030. Zur
further dosage see yohimbine.

 

[izo]

Medical application
In Cameroon, yohimbe is used in folk medicine to treat impotence as a result of witchcraft (cf. AMRAIN 1907).
Preparations containing yohimbe are also used in modern phytotherapy and in western medicine for the treatment of
Frigidity and impotence are used and applied in veterinary medicine (PAHLOW 1993: 4840.
In homeopathy,
»Yohimbinum« as an alternative remedy to Nuphar lutea. It »Excites the sexual organs, acts on the central nervous system and the
respiratory center. Is an aphrodisiac in physiological doses, but in all acute and chronic inflammations of the
Abdominal organs contraindicated.
Homeopathically it should be able to help with congestive states of the sexual organs. Caused
Hyperemia of the mammary glands and stimulates milk production.« (BOERICKE 1992: 802*)
ingredients
The trunk bark of trees older than 15 to 20 years contains 2 to 15% indole alkaloids: yohimbine (= corynine,
quebrachin), a-yohimbine (= corynanthidine,
isoyohimbine, mesoyohimbine, rauwolscine), ß-yohimbine (= amsonine), yohimbinine,
Corynanthine (= rough himbine), corynantheine, dihydrocorynantheine, alloyohimbine (= dihydroyohimbine), pseudoyohimbine,
Tetrahydromethylcorynanthein and ajmalicin (OLIVER-BEYER 1982: 39, PARIS and LETOUZEY 1960, POISSON 1964,
Roth et al. 1994: 544*).
The average content of yohimbine in the merchandise (cortex yohimbe) is between 1.67
and 3.4% (ROTH et al. 1994: 545*). In addition to the alkaloids, the bark contains tannic acid and a coloring agent (PAH LOW 1993:
484* ).

 

[izo]

Effect
The yohimbe bark enjoys the reputation of being a hallucinogen (SCHULTES and FARNSWORTH 1982: 189*). The psychoactive
Effect is mainly determined by the main active ingredient yohimbine (ROTH et al. 1994: 545*). yohimbine has
sympatholytic effects and a local anesthetic effect like cocaine, it also has a vasodilating effect, especially on
the sexual organs (OLIVER-BEYER 1982: 40). Yohimbine interacts with other psychotropic drugs (ROTH et al.
1994: 544*). Overdoses can be very unpleasant (SACHA RUNA and LADY SANNA 1995). to psychoactivity
see yohimbine.
Preparations made from the bark usually have only a weak or subtle effect.

 

[izo]

1981 - Alkaloids of Pausinystalia macroceras

Abstract
A study of the alkaloidal content of
trunk-barks of Pausinystalia macroceras
(K. SCHUM.) PIERRE, Rubiaceae, resulted
in the isolation of six alkaloids, five of
which are indole alkaloids that belong to
the yohimbane and heteroyohimbane
groups; among them, yohimbine was
found in major amount. Moreover, the
levorotatory isomer of calycanthine, a
quinoline dimeric tryptophane derived
base, has been isolated for the first time.
The phytochemical significance of calycanthine
and related alkaloids is discussed.

 

[izo]

2008 - Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry

In the present work, the qualitative and quantitative analysis of Pausinystalia yohimbetype
alkaloids in the barks of Rubiaceae species is presented using different analytical
approaches. Extracts of P. yohimbe were first examined by GC-MS and the major
alkaloids were identified. The quantitation of yohimbine was then accomplished by
non-aqueous CE (NACE) with diode array detection. This approach was selected in
order to use a running buffer fully compatible with samples in organic solvent. In
particular, a mixture of methanol containing ammonium acetate (20 mM) and glacial
acetic acid was used as a BGE. The same analytical sample was subjected to GCMS
and NACE analysis; the different selectivity displayed by these techniques
allowed different separation profiles that can be useful in phytochemical characterization
of the extracts. The linear calibration ranges were all 10–1000 lg/mL for
yohimbine by GC-MS and NACE analysis. The recovery of yohimbine was 91.2–94.0%
with RSD 1.4–4.3%. The LOD for yohimbine were 0.6 lg/mL by GC-MS and 1.0 lg/mL
by NACE, respectively. The GC-MS and NACE methods were successfully validated
and applied to the quantitation of yohimbine.

 

[izo]

2009 - Refractory priapism associated with ingestion of yohimbe extract

ABSTRACT
Extracts of the bark of the central African tree Pausinystalia yohimbe contain yohimbine, an indole alkaloid, which is used to treat
erectile dysfunction. The reported side effects of over-the-counter preparations of yohimbine include gastrointestinal upset, anxiety,
increased blood pressure, headache, agitation, rash, tachycardia, and frequent urination. In this report, we describe a severe case
of intractable priapism associated with the ingestion of yohimbe extract. Management required insertion of a proximal cavernosal
spongiosum shunt (Quackles shunt) in the operating room.

 

[izo]

2012 - Chromatographic fingerprint analysis of yohimbe bark and related dietary supplements using UHPLCUVMS

a b s t r a c t
A practical ultra high-performance liquid chromatography (UHPLC) method was developed for fingerprint
analysis of and determination of yohimbine in yohimbe barks and related dietary supplements.
Good separation was achieved using a Waters Acquity BEH C18 column with gradient elution using 0.1%
(v/v) aqueous ammonium hydroxide and 0.1% ammonium hydroxide in methanol as the mobile phases.
The study is the first reported chromatographic method that separates corynanthine from yohimbine in
yohimbe bark extract. The chromatographic fingerprint analysis was applied to the analysis of 18 yohimbe
commercial dietary supplement samples. Quantitation of yohimbine, the traditional method for analysis
of yohimbe barks, were also performed to evaluate the results of the fingerprint analysis. Wide variability
was observed in fingerprints and yohimbine content among yohimbe dietary supplement samples. For
most of the dietary supplements, the yohimbine content was not consistent with the label claims.

 

[izo]

2013 - Microscopic and UPLC-UV-MS analyses of authentic and commercial yohimbe (Pausinystalia johimbe) bark samples

Conclusions
Yohimbe bark, in transverse section, shows thick-walled
and strongly lignified fibers that are arranged in uniseriate,
bead-like, radial rows; cork cells with thickened, lignified
and pitted walls filled with reddish brown contents; and
abundant idioblasts, packed with sand crystals of calcium
oxalate, are scattered in the secondary cortex and phloem
parenchyma. In accord with previous studies, bast fibers
with striated walls, channeled lumina, and some fibers with
narrow, thinly lignified walls and wide lumina are reported
in the present work. Microscopic studies of 12 commercial
yohimbe samples revealed that three samples were probably
adulterated and four other samples contained various
levels of impurities. Microscopy is an effective tool for
identifying authentic yohimbe bark material. The UPLC–
UV–MS method revealed that one of the samples was
devoid of yohimbine, while in the other commercial samples
the alkaloid was present at levels of 0.1–0.91%. The
UPLC method is useful for achieving high-resolution
separations of yohimbe-containing samples. This method
can be effectively used in routine analysis involving a large
number of yohimbe samples.

 

[izo]

2018 - Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe

ABSTRACT: Ten new alkaloids (1−10), including two pairs of enantiomeric mixtures (5a,b and 6a,b), and 15 known
analogues (11−25) were obtained from the bark of Pausinystalia yohimbe. The structures of 1−25 were established by
spectroscopic methods, and the absolute configurations of compounds 1−10 were resolved by X-ray diffraction and ECD data
analyses. The in vitro immunosuppressive activities of selected isolates were tested. Compounds 11 and 16 exhibited moderate
inhibition with IC50 values of 16.8 and 27.6 μM against ConA-induced T lymphocyte proliferation and 13.5 and 40.5 μM
against LPS-induced B lymphocyte proliferation, respectively.

 

[izo]

papers used:

1981 - Alkaloids of Pausinystalia macroceras.pdf
2008 - Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry.pdf
2009 - Refractory priapism associated with ingestion of yohimbe extract.pdf
2012 - Chromatographic fingerprint analysis of yohimbe bark and related dietary supplements using UHPLCUVMS.pdf
2013 - Microscopic and UPLC-UV-MS analyses of authentic and commercial yohimbe (Pausinystalia johimbe) bark samples.pdf
2015 - Determination of Yohimbine in Yohimbe Bark and Related Dietary Supplements Using UHPLC-UVMS Single-Laboratory Validation.pdf
2018 - Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe.pdf
2020 - Yohimbine.pdf

 

[Neuroborean]

last profile, for now:

Corynanthe johimbe - Wikipedia

en.wikipedia.org

alkaloids on wiki:

Yohimbine - Wikipedia

en.wikipedia.org

Corynanthine - Wikipedia

en.wikipedia.org

Ajmalicine - Wikipedia

en.wikipedia.org

tried the extract last year, since it was a whole plant extract there was no effect. the shredded root bark tested almost 20 years ago was nice though, slightly halucinogenic. pure yohimbine is often described as anxiogenic.

I'm my opinion/experiene Yohimbe itself it's not anxiogenic, what's anxyogenic it's not knowing what to do with the amount of physical energy you gain from it,
just go for a walk, the "anxiety" (adrenaline) will dissapear in seconds once you start walking,
It's no good for studying, but mixing it with kratom (fast reds, greens...) and l-theanine makes it perfect,
mixed with kola nut it's also very nice, better than with coffee.
Strange that you didn't have effects with extract, it seems to be very powerful,

I only use low doses, the ORGASM enhancement it's something else, it doesn't always work but when it does... wow, it seems better than a cathinone or almost like moxy.

did you tried smoking it? that's the way it seems to be hallucinogenic.

 

[izo]

I just took the root bark orally and had and excellent tryptaminish like effect. It was nice and somewhat prosexual. The pure yohimbine is often touted as being somewhat anxoigenic.

 

[Neuroborean]

2018 - Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe

Odd enough I have the tendency to run LOW on my sugar level when taking yohimbe,
I thought that was going to be the opposite since epinephrine, like cortisol, tends to rise Blood Sugar. In this case it's not like that at all, and normally go low or sometimes hypoglycemic (today, for example, mixing it with haritaki).
Normally diabetics type 1 have a very good natural "keto-nic" metabolism, as our body it's used to burn proteins and fats when there's no sugar around, yohimbe makes this even more noticeable but my hypothesis is different:

I think that that inmunosuppresive alkaloids of yohimbe make my body less inflammatory, in terms of immune response (against the pancreas). It's well known lately (the last years) that diabetes type 1 is not like one attack on the pancreas, but a dysregulated immune system that attacks certain tissues non stop, creating inflammatory responses (not letting the pancreas to heal).
I think certain herbs, black seed oil, yohimbe, kratom... create a very good anti-inflammatory response on diabetics and it's all about immuno-supression or immuno-modulation.
@AbbeyLee

 

[Neuroborean]

I just took the root bark orally and had and excellent tryptaminish like effect. It was nice and somewhat prosexual. The pure yohimbine is often touted as being somewhat anxoigenic.

do you remember how much did you take?
for me eating the bark it's more active than the tea, but I tend to make tea instead of eating the bark, my doses are 2-3 grams. 1 teaspoon or teaspoon and a half.
I want to try bigger doses but there's some nausea and hypertension on medium doses...
I felt the tryptaminish effect more than once, it's psychedelic in terms of visual/auditory enhancemente, there's also some little headspace and the ego/confidence boost is fantastic.

 

[Neuroborean]

wow, 6 teaspoons is panic attack territory, that's for sure . It's not anxyogenic when you don't go overboard, but 6 teaspoons would be too strong for a lot of 1.90m gym-sculpted strongmen

"preparation and dosage
Only the dried bark is used. It can be extracted with alcohol (tincture) or prepared as a tea (cf.
SPEED 1996: 1460.
For a tea, six teaspoons of yohimbe bark per person with 500 mg of vitamin C are boiled for 10 minutes and then
drunk in sips (according to GOTTLIEB 1974: 76*, MILLER 1988: 1430."

 

[izo]

do you remember how much did you take?

Too long ago, I smuggled it in a bus along with some shrooms from nl to Germany. Must have been around 2005 or so. Don’t remember the dose but pure root bark is good. Perhaps I’m gonna try pure yohimbine to determine if other plant ingredients are what makes yohimbine so remarkable. It’s at least as good as psylocin, more mellow and energizing.