Stimulants Methamphetamine and blood clots?

[Specified]

Hello,

If ive haD blood clots in the past is it safe to use methamphetamine?

 

[Jabberwocky]

Hello,

If ive haD blood clots in the past is it safe to use methamphetamine?

No. If you do a google search for “methamphetamine thrombosis research” you will find many papers describing cases of clotting caused by meth. It probably depends a little bit on what the cause of your earlier clotting was.

 

[Specified]

That sucks donkey nuts. So I can't take meth anymore if I want to be on the safe side? FUCK!

What about Ketamine and Fentanyl?

 

[Jabberwocky]

The good news is that ketamine does not cause thrombosis in:

Rabbits

Studies of blood clotting system during dissociative anaesthesia with ketamine - PubMed

The effect of ketamine administered to 20 rabbits in a single dose and in fractionated doses on the blood clotting system was studied. The following blood clotting indices were determined: thrombelastography (TEG), plasma thrombin time, platelet count, euglobulin lysis time. No statistically...

pubmed.ncbi.nlm.nih.gov

Or People (at least not DVT, I don’t know about other forms clotting)

Local anesthesia and ketamine dissociation are not associated with deep venous thrombosis - PubMed

Local anesthesia and ketamine dissociation are not associated with deep venous thrombosis

pubmed.ncbi.nlm.nih.gov

But, some very basic research says that ketamine inhibits platelet aggregation which is one of the very early necessary stages of thrombosis.

Studies of blood clotting system during dissociative anaesthesia with ketamine - PubMed

The effect of ketamine administered to 20 rabbits in a single dose and in fractionated doses on the blood clotting system was studied. The following blood clotting indices were determined: thrombelastography (TEG), plasma thrombin time, platelet count, euglobulin lysis time. No statistically...

pubmed.ncbi.nlm.nih.gov

As for Fentanyl, I don’t know anything at all about opiates.

 

[Specified]

Ok thanks for the info. Could I get a list of what drugs I can take when I've had blood clots in the past ?

 

[Specified]

Shrooms? LSD?

 

[Jabberwocky]

In a major peer-reviewed meta-review of legal and illegal drugs links to blood clotting (thrombosis) the only drug found to have a significant risk (besides cocaine and it’s well-known cardio-vascular effects) was MARIJUANA. The review states that:

“Several cases of acute coronary syndromes have been reported.104–108 The patients affected are usually young and male. Thrombus formation in coronary arteries has been demonstrated on magnetic resonance imaging or at autopsy. Therefore, there is no doubt about the existence of a link between cannabis use and coronary occlusions. Arteritis and occasional ischemic stroke have been also reported.109 Venous thrombosis, on the contrary, seems exceptional.110 The causative mechanisms are still ill-defined. Platelet activation, endothelial damage, and increased oxygen demand due to tachycardia are probably involved, since venous thromboses are rare and no clotting change has ever been demonstrated. Coronary steal or coronaries no flow has also been proposed. Because of the huge economic interest, the toxicity of cannabis has been often minimized. The recent liberalization of the drug in some states of the United States with consequent taxations in order to improve the financial condition of these states is in line with the media underestimation of the problem.

The number of case reports is so large that every caring physician should include, in taking the history of the patient, information on cannabis use or abuse.

It is interesting to note that the only other illicit drug associated with arterial thrombotic events is cocaine and derivatives. No significant rate of MI has been associated with opiates.”

Reference: Girolami, A. et al. (2017) ‘Drug-Induced Thrombophilic or Prothrombotic States: An Underestimated Clinical Problem That Involves Both Legal and Illegal Compounds’, Clinical and Applied Thrombosis/Hemostasis, pp. 775–785. doi: 10.1177/1076029616652724.

 

[Fiori di Bella]

In a major peer-reviewed meta-review of legal and illegal drugs links to blood clotting (thrombosis) the only drug found to have a significant risk (besides cocaine and it’s well-known cardio-vascular effects) was MARIJUANA. The review states that:

“Several cases of acute coronary syndromes have been reported.104–108 The patients affected are usually young and male. Thrombus formation in coronary arteries has been demonstrated on magnetic resonance imaging or at autopsy. Therefore, there is no doubt about the existence of a link between cannabis use and coronary occlusions. Arteritis and occasional ischemic stroke have been also reported.109 Venous thrombosis, on the contrary, seems exceptional.110 The causative mechanisms are still ill-defined. Platelet activation, endothelial damage, and increased oxygen demand due to tachycardia are probably involved, since venous thromboses are rare and no clotting change has ever been demonstrated. Coronary steal or coronaries no flow has also been proposed. Because of the huge economic interest, the toxicity of cannabis has been often minimized. The recent liberalization of the drug in some states of the United States with consequent taxations in order to improve the financial condition of these states is in line with the media underestimation of the problem.

The number of case reports is so large that every caring physician should include, in taking the history of the patient, information on cannabis use or abuse.

It is interesting to note that the only other illicit drug associated with arterial thrombotic events is cocaine and derivatives. No significant rate of MI has been associated with opiates.”

Reference: Girolami, A. et al. (2017) ‘Drug-Induced Thrombophilic or Prothrombotic States: An Underestimated Clinical Problem That Involves Both Legal and Illegal Compounds’, Clinical and Applied Thrombosis/Hemostasis, pp. 775–785. doi: 10.1177/1076029616652724.

I’m so impressed with your answers to Specie!

 

[Specified]

In a major peer-reviewed meta-review of legal and illegal drugs links to blood clotting (thrombosis) the only drug found to have a significant risk (besides cocaine and it’s well-known cardio-vascular effects) was MARIJUANA. The review states that:

“Several cases of acute coronary syndromes have been reported.104–108 The patients affected are usually young and male. Thrombus formation in coronary arteries has been demonstrated on magnetic resonance imaging or at autopsy. Therefore, there is no doubt about the existence of a link between cannabis use and coronary occlusions. Arteritis and occasional ischemic stroke have been also reported.109 Venous thrombosis, on the contrary, seems exceptional.110 The causative mechanisms are still ill-defined. Platelet activation, endothelial damage, and increased oxygen demand due to tachycardia are probably involved, since venous thromboses are rare and no clotting change has ever been demonstrated. Coronary steal or coronaries no flow has also been proposed. Because of the huge economic interest, the toxicity of cannabis has been often minimized. The recent liberalization of the drug in some states of the United States with consequent taxations in order to improve the financial condition of these states is in line with the media underestimation of the problem.

The number of case reports is so large that every caring physician should include, in taking the history of the patient, information on cannabis use or abuse.

It is interesting to note that the only other illicit drug associated with arterial thrombotic events is cocaine and derivatives. No significant rate of MI has been associated with opiates.”

Reference: Girolami, A. et al. (2017) ‘Drug-Induced Thrombophilic or Prothrombotic States: An Underestimated Clinical Problem That Involves Both Legal and Illegal Compounds’, Clinical and Applied Thrombosis/Hemostasis, pp. 775–785. doi: 10.1177/1076029616652724.

So I can touch any drug besides Marijuana, Cocaine and meth. What about other stimulants like research chemicals?

Where did you find that link?

 

[deficiT]

If cocaine and meth are contraindicated, it would be safe to assume that most other stimulants are as well.

 

[Jabberwocky]

So I can touch any drug besides Marijuana, Cocaine and meth. What about other stimulants like research chemicals?

Where did you find that link?

I’m not making any comment on drugs you CAN take safely because there are too many unknowns. I’m only advising which ones you probably SHOULD NOT based on the information provided.

Most of this information i find via searching pubmed and other full text medical databases I can access via my university. You should be able to find a lot of it by searching Google Scholar but you will often only get abstracts and not the full article there.

 

[Specified]

What about if i take blood thinners

 

[Lysosomalstorage]

Stimulants + blood thinners does the opposite you'll just be at risk of bleeding internally. You could try and get your haemoglobin tested but that's a pretty unreliable way of judging future risk of clots. Is bleeding or clots really worth stimulants and possible psychosis?

 

[Specified]

True...ill just stick to other drugs.

 

[Frazzled1990]

Hello,

If ive haD blood clots in the past is it safe to use methamphetamine?

It's never "safe" to use Methamphetamine. You're always taking a risk with it. Even if you have zero clotting right now, the narrowing of the arteries could quite easily create a new one if there's too much plaque build up somewhere in an artery.

You can combat artery narrowing with Magnesium, although I doubt it would do much to keep the arteries open when stacked up against the potency of Methamphetamine.

 

[Specified]

It's never "safe" to use Methamphetamine. You're always taking a risk with it. Even if you have zero clotting right now, the narrowing of the arteries could quite easily create a new one if there's too much plaque build up somewhere in an artery.

You can combat artery narrowing with Magnesium, although I doubt it would do much to keep the arteries open when stacked up against the potency of Methamphetamine.

Thanks for the info! I'll steer clear from meth and any stimulants.

 

[tweakerguy]

Is bleeding or clots really worth stimulants and possible psychosis?

Apparently you've never used the stuff.
I'd like to think if I were faced with that scenario I'd be able to just walk away, but I'd probably be kidding myself.

 

[tweakerguy]

Thanks for the info! I'll steer clear from meth and any stimulants.

Very nicely packaged thread lol

So is this the real 'Specified', or the replacement i've been hearing so much about?

 

[tweakerguy]

It's never "safe" to use Methamphetamine. You're always taking a risk with it.

That's not true.
And I'd argue the activities and situations most people find themselves in during a binge are more dangerous than the substance itself, not unlike LSD or PCP.
However if you're really prone to blood clotting, thats different.
Hard stimulants (hard anything really) wouldn't be the wisest choice.

 

[Frazzled1990]

That's not true.

Hard stimulants (hard anything really) wouldn't be the wisest choice.

Right.