N&PD Moderators: Skorpio
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SYDNEY
2-(N-hydroxyethylamino)-1-phenylpropane
PERTH
1-(4-bromoindole-3-yl)-2-dimethylaminoethane
The West (oeste) Is Associated With Wisdom; The East (este) With Money, Property, & Prestige.
LAVENDAR
1-isopropyl-4-oxocyclohex-2-eneJabberwocky
Frumious Bandersnatch
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I'm actually thinking about trying this new 2 in 1 antipsychotic later this year when it comes out. The reason being that I am curious about what's so great about being addicted to opiates. Yes, I know that 'curiousity killed the cat." But, like Schrodinger's cat, this here cat is BOTH alive & dead! And loved either way. 
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JONES 21
1-(1,3-benzodioxole-5-yl)-2-(2-hydroxyethylamino)propane
PENNINGTON 48
2-methylamino-1-(4-amylphenyl)-propane
Sister Aimee
The Torah
The Talmud
The Pentateuche
The Koran
The Tao te Ching by Lao Tzu
The Religions of Man by Huston Smith
The Bhaghavad Gita
The Rig Vedas
Suzanne Vega
Viva Las Vegas, 'the fertile (!) plane.'
VISA Green Cards R.E.M. Madonna. Ciccone Jennifer Cohen
J.P. Morgan Chase The Muppets Took The Manhattan Project
Going Viral Is A Thing.
Linkin Park.
A Pill Press.
North Druid Hills.
"I Will Lift Up My Hands Unto The Hills From Whence My Salvation Comes."--La Santa Biblia. Radiohead. Augusta, ME (Maine). Same Name Fun & Games. A Digital Eternity.Rectify
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PLURIPOTENT
1-(4-methoxyphenyl)-1,3-bis-(dichloroacetoxy)-2-(dichloroacetamido)propane
-investigational new antibiotic / wart, skin cancer, age spot chemical cauterizer
-inspired by chloramphenicol, a natural product antibiotic found in the ocean
EDIT: When In Doubt, Leave The Stereochemistry Out.Rectify
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RASPBERRY_CHAMPAGNE.
1-(4-methoxyphenyl)-2-(2-hydroxyethylamino)propane
Cleverness Hace Lo Que Se Puede.
¡Genius Hace Lo Que Ich MuB!
We Are Living In The Land Of Shadows.
Take A Walk Through The Crystal Meadows.
SID_CAESAR_AUGUSTUS.
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-hydroxylaminopropane
Pizza! Pizza!
ZUESY_KIM.
1-(3,4-methylenedioxy-6-(methylthio)phenyl)-2-aminopropane
OPEN_SESAME_STREET'S_BEATIFIC_BEAT.
1-(3,4-methylenedioxy-6-hydroxyphenyl)-2-aminopropane
Las Puertas Estan Abiertas.
Yo Soy La Llave.Jabberwocky
Frumious Bandersnatch
bruhhh
I'm actually thinking about trying this new 2 in 1 antipsychotic later this year when it comes out. The reason being that I am curious about what's so great about being addicted to opiates. Yes, I know that 'curiousity killed the cat." But, like Schrodinger's cat, this here cat is BOTH alive & dead! And loved either way.
i wish you luck with that
as in, i hope you dont have to get addicted cuz its hell you kinda stop giving a fuck about things that once made u happy until opiates are your only happiness
Truth.
i wish you luck with that
as in, i hope you dont have to get addicted cuz its hell you kinda stop giving a fuck about things that once made u happy until opiates are your only happiness
Any addiction sucks, but opiate addiction REALLY really sucks.izo
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Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines
Abstract
A representative series of N-substituted derivatives of the morphine-based trans-4a-aryldecahydroisoquinoline were synthesized and evaluated for opioid analgesic activities. Compounds with potent analgesic activity and high affinities for the mu and kappa opioid receptors were discovered. The effect of varying the N-substituent in the trans-4a-aryldecahydroisoquinoline paralleled, to a certain extent, previous findings with other morphine part structures. Replacement of the N-methyl with a phenethyl group significantly increased analgesic potency. The N-cyclopropylmethyl analogue was found in rodents to have mixed agonist-antagonist properties; however, its antagonist activity was far weaker than those reported for the N-(cyclopropylmethyl)morphinan and -benzomorphan derivatives. Resolution of the stereoisomers and determination of their absolute configuration by X-ray crystallography showed that the opioid receptor effects were predominantly found with the 4aR,8aR isomer, the same relative absolute configuration of morphine. Unexpectedly, the 4aR,8aR N-cyclopropylmethyl analogue (compound 30), which in rodents had mixed agonist-antagonist properties similar to those of pentazocine, was found in rhesus monkeys to behave as a full morphine-like agonist.
Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines - PubMed
pubmed.ncbi.nlm.nih.gov
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WIDGET
1-(2-hydroxyethyl)piperidin-4-yl
phenyl ether
FIDGET
1-(2-hydroxyethyl)piperidin-4-yl 3,4-methylenedioxyphenyl ether
NaOMe (Na+[-O-CH3])
NAOMI
Sodium Methoxide
The Williamson Ether Synthesis
CHRIS
3,5-dimethoxy-1-(2-aminoethyl)-benzene-4-yl (2-hydroxyethyl)piperidine-4-yl ether
RICK
2,6-dimethoxy-1-(2-aminoethyl)-benzene-4-yl-(2-aminopropane)
LIL DANNY
1-(4-ethylphenyl)-2-aminopropaneRectify
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PEEWEE
N-isopropyl-1-phenyl-2-aminoethane
ANDOUILLE
1-phenyl-2-(dichloroacetamido)propane
GUBERNATORIAL
1-(4-ethoxy-3-methoxyphenyl)-2-methylaminopropan-1-one
HYBRID_THEORY
N-(1-methyl-2-phenylethyl)-2-(indole-3-yl)ethyl-N-methylamine
AWAKE
N-(1-methyl-2-phenylethyl)-2-(indole-3-yl)-(1-methylethyl)amine
Sometimes I Take Medicine To Kill Neurons. But Usually I Take Medicines To Regrow Neurons.
ELASTIC_ELATEMENT
1-(4-hydroxyindole-3-yl)-2-aminopropaneizo
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Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug
Abstract
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre- or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug - PubMed
pubmed.ncbi.nlm.nih.gov
Phenibut (β‐Phenyl‐GABA): A Tranquilizer and Nootropic Drug - PMC
www.ncbi.nlm.nih.gov