indigoaura
Bluelighter
- Joined
- Jan 4, 2009
- Messages
- 1,707
I was researching another topic, and I stumbled down a rabbit hole that may be relevant to our thread.
Specifically, I was researching Zinc deficiencies and how Zinc impacts hormone levels.
First, I read this, "Zinc also improves the stability of oxytocin, and the stabilization effect is correlated with the ability of the divalent metal to interact with oxytocin. Zinc is essential for the binding of oxytocin to its cellular receptor " (https://www.intechopen.com/books/nutritional-deficiency/zinc-deficiency).
That made me stop and ponder the implications of Zinc deficiency on the MDMA experience. So, I decided to see if there were additional possibly relevant connections between Zinc & neurochemistry.
That led me to this dense article:
www.ncbi.nlm.nih.gov
Admittedly, I have only scratched the surface of that article. However, there are potentially significant interactions. The article goes into detail about Zinc's role with SERT, DAT, and NET transporters as well as the entire serotonergic system. I had no idea that Zinc played such a tremendous role in brain functioning and depression.
If I am reading all of this correctly, it seems like Zinc deficiency could lead to improperly functioning oxytocin receptors as well as a sub-optimal serotonergic system.
Someone asked awhile back if all of the people who are experiencing MehDMA could have a common factor between them. What if that factor is Zinc deficiency?
Specifically, I was researching Zinc deficiencies and how Zinc impacts hormone levels.
First, I read this, "Zinc also improves the stability of oxytocin, and the stabilization effect is correlated with the ability of the divalent metal to interact with oxytocin. Zinc is essential for the binding of oxytocin to its cellular receptor " (https://www.intechopen.com/books/nutritional-deficiency/zinc-deficiency).
That made me stop and ponder the implications of Zinc deficiency on the MDMA experience. So, I decided to see if there were additional possibly relevant connections between Zinc & neurochemistry.
That led me to this dense article:
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity - PMC
Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in ...

Admittedly, I have only scratched the surface of that article. However, there are potentially significant interactions. The article goes into detail about Zinc's role with SERT, DAT, and NET transporters as well as the entire serotonergic system. I had no idea that Zinc played such a tremendous role in brain functioning and depression.
If I am reading all of this correctly, it seems like Zinc deficiency could lead to improperly functioning oxytocin receptors as well as a sub-optimal serotonergic system.
Someone asked awhile back if all of the people who are experiencing MehDMA could have a common factor between them. What if that factor is Zinc deficiency?