LabRat74
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MDMA &
Empathogenic
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MDMA Moderators:
Does Cocaine Ruin MDMA?
- Thread starter Dexta
- Start date
AutoTripper
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Do you have a version of this question that's even more self-explanatory?
epic11
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Sure Mr. just registered. Change "I've" to "we've" in my statement, and also the next "I" to "we" Hope you understand. Relax my man. We are on the same team. Bluelight isnt new, we have been here a long time.
LabRat74
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Imagine thinking the number of posts accrued had anything to do with the relevance or manner of what you said.
It reads pretty damn judgy. I'm very relaxed lol.
BlueBull
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Very interesting. Thank you for correcting me, learned something new today. I am going to read the entire study when I have some time, I am curious about the dosages and methodology involved. It will be interesting to compare them to the earlier research I've read on the subject
LabRat74
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No worries it's a very common misconception even among those who have professions in the field. The review I linked covers several substances but pg 34 and 35 have the stuff about c'lene.
Further reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812060/
"The cocaine and BE plasma concentration-time profiles after oral administration of cocaine with and without ethanol are shown in Fig. 3. Ethanol coadministration produced a 4-fold increase in cocaine AUC0–∞. Oral cocaine systemic bioavailability and Cmax were significantly increased by 4- and 3-fold, respectively, after ethanol administration. Ethanol pretreatment did not affect oral cocaine elimination half-life. The BE AUC0–∞ was approximately 2.5-fold higher with ethanol coadministration than with oral cocaine given alone. Cocaethylene was not detected after the coadministration of ethanol and intravenous cocaine (lower limit of detection was 25 ng/ml), but when ethanol was coadministered with oral cocaine, the mean peak cocaethylene concentration was 30.9 ± 7.3 ng/ml. A significant 33% increase in the intravenous cocaine AUC0–∞was seen with the coadministration of ethanol. Ethanol did not significantly affect the BE AUC0–∞ for intravenous cocaine."
I actually LOVE the effects of cocaine on it.
I hate the effects after it wears off, it leaves me totally sunk
I can honestly say despite doing drugs in the multiple hundreds of times all over the world for 30 years approx, not one person has ever specifically said cocaine negates MDMA
JUst bizare, maybe it's an age thing and the younger generation know this and us older buggers never learnt.
Is there somewhere I can read more on this receptor stuff?
BlueBull
Moderator: MDMA
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Just searching for 'cocaine' in this section does seem to produce some threads asking about this combo
If you're wondering about the methods of action of a specific drug, the search term to use is either 'pharmacology' or more specific 'pharmacodynamics', for MDMA specifically this would be 'MDMA pharmacodynamics'. You can also check the directory sticky at the top of this section, it should contain some links to relevant information. If you're wondering more about the general topic, 'neuroscience basics' on google will give you an overview while 'neurochemistry basics' and 'cellular neuroscience basics' will give you the basics about things like transporters, synapses, receptors,...
Hilopsilo
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Errr... isn't this whole thread you asking if coke makes MDMA shitty? But you're saying you love it? If you love the effects of cocaine on MDMA, i'm confused why you're asking if doing coke on MDMA is why your MDMA experiences are lack luster. If you're doing bumps of coke throughout your roll, yeah thats gonna totally dilute and ruin it, I guarantee it
It's pretty well known that coke ruins MDMA, just throw "mdma and cocaine combo reddit" into google and theres probably hundreds of people asking the question and 99% of replies are that its utter crap.
That said, in real life I've been around a ton of people who have combined them anyways, a lot of people just want to get as fucked up as possible and don't care entirely how they're fucked up, just, more is more. Aside from potential harm and health risks, there is nothing inherently wrong with wanting that, I just think there are maybe better ways. MDMA works very will on combination weed, psychedelics, ketamine, and even alcohol if consumed with care, just not coke.
Regardless, just try MDMA without coke and see how it is for yourself
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draculic acid69
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Yeah the coke might kill the magic of mdma if used before or during.id save it for after during the comedown
Nope, absolutely do not love the effects of them together, the oppposite. Love the effects of both of them however.
First post explains it fella. Synopsis , Love coke. Love MDMA. Never combined them in the old days. Came back to the scene, lot of combining going on. Tried it - didn't work for me well asking if this is known quantity or a "me" thing.
Clearer now?
That indeed appears to be the case. Very much looking forward to the next night out ditching this model. I was left wondering ifg it was bad coke, bad MDMA etc a couple of times but this and other research has validated it.
Interestingly it's incredibly popular, at least around my way. Almost a natural combination it seems, along with a lot of booze, something I also never did on MD.
I have no objection to being fucked up but not being happy while being fucked up on good MD I object to strenuously.
I was wondering was it an age issue, had I just gotten to old for this shit, was my MD crap, my coke nasty..
Either way, I feel encouraged the consensus is it does you no favours at all and I should still be able to enjoy my high.
As per initial post. I did MDMA sans booze or coke for nearly 15 years - no issues.
It's been my reintroduction to the scene that's been a mixed bag the last year or so.
ageingpartyfiend
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We discovered in the early 90's (when mdma was awesome) that the mix with cocaine pretty much completely killed the mdma high...certainly the empathic element of it and the heightened music appreciation. It's an awful combo and I'm truly surprised to read that some are not aware of this, or that they disagree.
If you must combine the two, wait until you've pretty much come down from the mdma, then start on your coke. It's still not all that but at least you'll feel the cocaine to some degree that way. From a harm reduction standpoint however the advice would be to stick to one stimulant per session. Also the comedown from this combo is seriously grim, ugh
If you must combine the two, wait until you've pretty much come down from the mdma, then start on your coke. It's still not all that but at least you'll feel the cocaine to some degree that way. From a harm reduction standpoint however the advice would be to stick to one stimulant per session. Also the comedown from this combo is seriously grim, ugh
It's such a strange thing I don't ever remember this being the general tone . I actually worked in probably the most popular of the major big night brands for SEVEN years and I can't remember for the life of me this ever being a thing. That said, as per my original post,it rarely happened so perhaps that's why.
You would think. I swear the coke entirely wiped out the MD. I fell asleep as soon as I got home and had virtually no come down at all.
Appreciate your contribution.
emkee_reinvented
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It is, or should be common knowledge, Cocaine is a perfect way to ruin a MDMA high.
Probably the SRI action is the main contributing factor. But the high is so opposed and I can imagine that in itself it overpower's the MDMA.
After coming down on XTC Coke work's like a charm though. Very unhealthy, but it is def better then the usual efffects it has.
Probably the SRI action is the main contributing factor. But the high is so opposed and I can imagine that in itself it overpower's the MDMA.
After coming down on XTC Coke work's like a charm though. Very unhealthy, but it is def better then the usual efffects it has.
BlueBull
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It is, I think, very much dependent on the location whether or not this combo is done regularly and whether or not people are aware of the effects coke has on MDMA. Where I live, people generally do not combine them, most of them because they are aware of the properties of this combo. That said, certain crowds are the exception to this, those are the people that just want to get as fucked up as possible as someone said earlier. True story, I once ran into a group that all took a huge amount of coke and drank a lot of booze but they had also all taken viagra, not because of the well-known property of the drug but because according to them it gave them a buzz. Those kinds of people are found all over the world and generally don't care what drugs they combine, as long as they're as much removed from sober as possible