JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,465
I shouldn't have to ask this question but, when it comes down to it - how's it done?
Cause I can't find receptor affinity/Ki values for H1, 2 or 3, and short of that, I'm at a loss to understand how potency of by example, a standard OTC anti-histamine like diphenhydramine or promethazine can be compared to the anti-histamine I'm most used to, mirtazapine.
Cause I recently had a piece of surgical stainless steel removed from my jaw and it seems I no longer require the meds I've been taking; a combo of mirtazapine and atomoxetine.
However, it seems there's a little insomnia now without the mirtazapine so, I've been trying to replace it with an OTC anti-histamine.
The pharmacists have basically been telling me, quite specifically that, it'll take about a box of standard OTC anti-histamines to compare to even 15 mg of mirtazapine.
How do they know this so specifically?
If there was a Ki chart of affinities to histamine receptors, like there is for 5HT receptors etc - I'd say, I understand.
But this doesn't exist.
So - how do they know how to compare potencies so accurately?
Cause I can't find receptor affinity/Ki values for H1, 2 or 3, and short of that, I'm at a loss to understand how potency of by example, a standard OTC anti-histamine like diphenhydramine or promethazine can be compared to the anti-histamine I'm most used to, mirtazapine.
Cause I recently had a piece of surgical stainless steel removed from my jaw and it seems I no longer require the meds I've been taking; a combo of mirtazapine and atomoxetine.
However, it seems there's a little insomnia now without the mirtazapine so, I've been trying to replace it with an OTC anti-histamine.
The pharmacists have basically been telling me, quite specifically that, it'll take about a box of standard OTC anti-histamines to compare to even 15 mg of mirtazapine.
How do they know this so specifically?
If there was a Ki chart of affinities to histamine receptors, like there is for 5HT receptors etc - I'd say, I understand.
But this doesn't exist.
So - how do they know how to compare potencies so accurately?