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Mental Health Coming off Invega Sustenna (Paliperidone) v3

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Does anybody else feel emotions coming from the stomach but not quite reaching the brain? It feels like they’re trapped there somehow.

Also does anyone else have a burning/tingling sensation in certain parts of the brain in response to certain things? It almost feels as though it’s the neurotransmitters trying to work, the brain trying to be stimulated, but not quite reaching all the way.
 
Hopeful29 said:
Also does anyone else have a burning/tingling sensation in certain parts of the brain in response to certain things? It almost feels as though it’s the neurotransmitters trying to work, the brain trying to be stimulated, but not quite reaching all the way.
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Invega antagonizes post-synaptic dopamine receptors. When your brain tells your neurons (brain cells) to fire dopamine, it gets released into the synapse, which is the space between neurons. (see my profile picture, the neuron on the left is pre-synaptic and the one on the right is post-synaptic) Dopamine which has been released into the synapse is called 'free dopamine'. (yellow stuff in my profile pic) The free dopamine affects your mood, body's functions etc, the dopamine inside neurons is basically inactive and won't affect anything, it's just stored in there.
I suggest you and everyone else to try bupropion (wellbutrin, voxra etc..). It blocks the reuptake of dopamine from the synapse back into pre-synaptic neuron, which results in more free dopamine between neurons. When there's more free dopamine around, even though your post-synaptic receptors are antagonized, some will find it's way through. At least that's my hypothesis.
Think it like this; you have a plastic bag which has a small hole in it. You fill it up with just a drop of water. The chances of that drop going through the hole are quite small. Now fill up the bag fully and the water WILL find it's way through. Maybe not the best allegory out there but you get the point. Wellbutrin only took me like 4-5 days to start working and once it did, it significantly relieved the anhedonia, anxiety, depression, insomnia and so on. And I haven't had any side effects from it.

Hopeful29 said:
Does anybody else feel emotions coming from the stomach but not quite reaching the brain? It feels like they’re trapped there somehow.
Click to expand...
I didn't have that kind of feeling but I think it could be because serotonin is primarily found in the enteric nervous system located in the gastrointestinal tract and invega antagonizes some serotonin receptor types too.
 
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i tend to laugh alot the last few days does anyone here do that too? and what does it mean im getting my emotions back?
 
xeplionisbad said:
i tend to laugh alot the last few days does anyone here do that too? and what does it mean im getting my emotions back?
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That's exactly what it means brother, I too noticed that whilst I was recovering. At first nothing made me laugh or even happy but then eventually some comedy shows really made me laugh and that's when I noticed the poison was wearing off. At sixth and seventh months off the crap I really started to make a good recovery, just hang in there =)
 
xeplionisbad said:
i tend to laugh alot the last few days does anyone here do that too? and what does it mean im getting my emotions back?
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that's amazing man!

I can have a hard time smiling and I don't even use AP's right... so I'm proud of anyone here able to smile and laugh in life. Enjoy the emotions coming back, should be getting better!

Every brain is unique. Every person is unique. It's unfortunate the psychiatric community would push medications that could have such long-lasting repercussions. They need to only employ short-lasting ones for people in situations which may require them. That is the future of the market and I don't know why the drug companies are dragging their heels in the dirt over this.
 
NoMoreZombi said:
Psychiatrists should be forced to take the highest dose of antipsychotics. That way they would know how beneficial they are.
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This is true, the psychiatrists claim that most of the negative symptoms of schizophrenia are caused by the illness itself but now that I have witnessed the side effects of Invega, I can tell those symptoms are caused by the medication, not the illness. I don't have schizophrenia but I had every single "negative symptom" of schizophrenia which is kinda fucked up.

Negative Symptoms of Schizophrenia
  • Apathy. ...
  • Absent, blunted or incongruous emotional responses. ...
  • Reductions in speech. ...
  • Social withdrawal. ...
  • Lack of pleasure
  • Impaired attention. ...
  • Anhedonia. ...
  • Sexual problems. ...
  • Memory problems
  • Lethargy.
When someone is battling which such a horrible condition as schizophrenia is, all those symptoms should be avoided more than anything. People with schizophrenia could live a normal life if the medication for the condition wouldn't be so fucked up. The newest research shows that dopamine might not even be involved in sz, it might be caused by disturbances in glutamate regulation. Research has even shown that CBD alone could be beneficial for people with sz, but pharma industry won't back this up because they would lose god damn billions and billions if everyone could just grow their own anti-anxiolytics, -depressants and -psychotics in their own backyard.
 
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PhucInvega said:
Invega antagonizes post-synaptic dopamine receptors. When your brain tells your neurons (brain cells) to fire dopamine, it gets released into the synapse, which is the space between neurons. (see my profile picture, the neuron on the left is pre-synaptic and the one on the right is post-synaptic) Dopamine which has been released into the synapse is called 'free dopamine'. (yellow stuff in my profile pic) The free dopamine affects your mood, body's functions etc, the dopamine inside neurons is basically inactive and won't affect anything, it's just stored in there.
I suggest you and everyone else to try bupropion (wellbutrin, voxra etc..). It blocks the reuptake of dopamine from the synapse back into pre-synaptic neuron, which results in more free dopamine between neurons. When there's more free dopamine around, even though your post-synaptic receptors are antagonized, some will find it's way through. At least that's my hypothesis.
Think it like this; you have a plastic bag which has a small hole in it. You fill it up with just a drop of water. The chances of that drop going through the hole are quite small. Now fill up the bag fully and the water WILL find it's way through. Maybe not the best allegory out there but you get the point. Wellbutrin only took me like 4-5 days to start working and once it did, it significantly relieved the anhedonia, anxiety, depression, insomnia and so on. And I haven't had any side effects from it.


I didn't have that kind of feeling but I think it could be because serotonin is primarily found in the enteric nervous system located in the gastrointestinal tract and invega antagonizes some serotonin receptor types too.
Click to expand...


Thanks for your feedback, it means a lot! With regards to antidepressants, I’m a bit worried to take them as I don’t want to mess with the neurochemicals even more. I am taking St Johns Wort and have just started taking niacin so I’m hoping these have some kind of effect.

With regards to the tingling sensation, I’m wondering if this might be the release of a lot of neurotransmitter and the resultant feeling of them being blocked from entering the receptor.
 
Hopeful29 said:
With regards to antidepressants, I’m a bit worried to take them as I don’t want to mess with the neurochemicals even more. I am taking St Johns Wort and have just started taking niacin so I’m hoping these have some kind of effect.
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Wellbutrin works way differently than regular antidepressants such as SSRI's, SNRI's and so on. I wouldn't touch any other antidepressant even with a stick. And as for the St Johns Wort, some claim it speeds up the detox process but that isn't true. SJW induces some liver enzymes which indeed break down drugs but since paliperidone palmitate is mostly excreted renally it won't speed that up. But if it works for you, of course keep using it. And SJW also inhibits the reuptake of serotonin, dopamine and noradrenaline so it too messes with your neurochemicals. But if you can handle the situation without drugs, it's a lot better.
 
NoMoreZombi said:
Psychiatrists should be forced to take the highest dose of antipsychotics. That way they would know how beneficial they are.
Click to expand...
I have *always* contended psychiatrists should be avid drug users to understand what they're going to put their patients through potentially. Just my 2c.

Now should they have to take antipsychotics? Maybe not. But someone like me would *only* give an AP to a patient who was *willing* to take it and/or basically requested it from me. If you are exhibiting psychotic symptoms normally BZD's like lorazepam, clonazepam, alprazolam work just fine to alleviate symptoms. I don't understand why they don't just keep you guys sedated for a few days and then taper you off. It doesn't make sense. I've seen BZD's work for people with schizophrenia. I don't get it.

I would only use medicine I feel I would use on myself on patients *unless* they requested for something they thought was necessary. And if I was gong to recommend someone take an AP I would tell them the *LONG* list of *VERY SCARY* side effects, so they are an informed patient.

I couldn't live with myself if I prescribed drugs for the kickbacks and didn't care what happened to the individual. That is so unbelievably heartless. My heart goes out to EVERYONE Here trying to regain emotions/happiness again. PLEASE know that recovery MAY be possible and I'm hearing it largely IS for some users here. That doesn't mean some will never recover; there might be future pharmacological interventions that might help you guys. Stay hopeful, and talk out your issues and please, just please keep this a safe space for everyone. <3
 
Captain.Heroin said:
I have *always* contended psychiatrists should be avid drug users to understand what they're going to put their patients through potentially. Just my 2c.

Now should they have to take antipsychotics? Maybe not. But someone like me would *only* give an AP to a patient who was *willing* to take it and/or basically requested it from me. If you are exhibiting psychotic symptoms normally BZD's like lorazepam, clonazepam, alprazolam work just fine to alleviate symptoms. I don't understand why they don't just keep you guys sedated for a few days and then taper you off. It doesn't make sense. I've seen BZD's work for people with schizophrenia. I don't get it.

I would only use medicine I feel I would use on myself on patients *unless* they requested for something they thought was necessary. And if I was gong to recommend someone take an AP I would tell them the *LONG* list of *VERY SCARY* side effects, so they are an informed patient.

I couldn't live with myself if I prescribed drugs for the kickbacks and didn't care what happened to the individual. That is so unbelievably heartless. My heart goes out to EVERYONE Here trying to regain emotions/happiness again. PLEASE know that recovery MAY be possible and I'm hearing it largely IS for some users here. That doesn't mean some will never recover; there might be future pharmacological interventions that might help you guys. Stay hopeful, and talk out your issues and please, just please keep this a safe space for everyone. <3
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The reason why they prescribe antipsychotics and insist the patient take them long term is because that's how pharma makes money. Plain and simple.

There is plenty of research which proves both that APs cause brain shrinkage in long term use (which incidentally explains the cognitive decline they induce) and that long term recovery is better when patients are tapered off APs.

Personally, I am not against the use of APs for acute cases of psychosis. But once the patient is stable they should be weaned off.
 
NoMoreZombi said:
Psychiatrists should be forced to take the highest dose of antipsychotics. That way they would know how beneficial they are.
Click to expand...
And force them to work with that on blood... They think se are week and font have solution.. But the solution its force them to take they own medicine
 
Captain.Heroin said:
that's amazing man!

I can have a hard time smiling and I don't even use AP's right... so I'm proud of anyone here able to smile and laugh in life. Enjoy the emotions coming back, should be getting better!

Every brain is unique. Every person is unique. It's unfortunate the psychiatric community would push medications that could have such long-lasting repercussions. They need to only employ short-lasting ones for people in situations which may require them. That is the future of the market and I don't know why the drug companies are dragging their heels in the dirt over this.
Click to expand...
Agreed and good idea
 
Captain.Heroin said:
And if I was gong to recommend someone take an AP I would tell them the *LONG* list of *VERY SCARY* side effects, so they are an informed patient.
Click to expand...
When I was prescribed invega the psychiatrist told me nothing but how 'modern and researched' drug it is. She didn't tell me anything about it's side effects, nothing. First months on this poison, literally all I wanted to do was inject her with this shit and tell her how modern this crap is. Smh
 
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