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Rectify's molecular poetry thread

^ that should work. 4’-methoxycocaine isnt devoid of activity so methylphenidate analog should follow.
At least, one of the weird metabolite of cocaine is 4’-methoxy-3’-hydroxycocaine.(minor)
Apartt fron the major metabolites of N-desmethylcocaine, Methylecgonine, Benzoylecgonine.
 
You still have not backed up your claim to be in drug design. It still has absolutely zero substance WHATSOEVER; and given your repetitive posting of utter, total garbage about drugs that all you have been able to do in any such instance, is to 'assign' a trivial name to the structure devoid of meaning, prancing about as if you are Sasha Shulgin himself, whilst being able to give not ONE trip report. If you were anything but a liar,regarding being a 'drug designer' then you would have actually MADE, and tested these garbage molecules, and given us trip reports as feedback. Being a drug designer. well, it might surprise you Dresden; but it involves actually designing drugs. Drawing pictures, deciding what name you will pull from out of your arse and not even making educated reasoning as to WHY these specific molecules have been drawn; what activity you expect they would have and why doesn't make you a 'drug designer'.

Tell us, just how many of these compounds you have actually synthesized, how many have undergone biossay? or am I right in my belief that you have, in reality, not synthesized a single one of them much less ever tasted, and that all you have ever done is depict structures using chemdraw or similar and given them meaningless names.

The way you have acted, posting this meaningless dreck, that justifies our asking you to back up your claims. So, back up your lofty claims, or admit to us all, that you are a liar and stop with the posting of this damnable, disgraceful spammy and meaningless garbage. I find it absolutely unbelievable that this spamming of total fucking shit and lies has been allowed in ADD. Its fucking shocking to be honest, that this GARBAGE has been allowed to continue.

So, the time for you to prove the truth of your words, or for you to admit to us all that you are, in actual fact, telling us all lies and stop the shitspeak.
 
Who do you think you are talking to like that? I don't have to explain or prove shit to you, punk. Fuck off.
 
Christ, I told you to back up a claim you yourself made. If you say it, you ought to be able to back it up. Show some knowledge, not necessarily claim to have done a specific (potentially incriminating) act at a given time or place, just knowledge, you have shown and contributed nothing.`

'sblood, I just took a fucking dump, the kind that feels like its going to go on until judgement day, and while I might barely able to STAND, I would still want you nowhere near my lab. From your posting history, I SERIOUSLY doubt any of the 'named' 'spirit molecules' could be made by you, you'd be a borohydride reduction away from taking yourself up in a pyrophoric fireball =D

Edit for the brain dead among us-I speak to you, dresden, worthless son of a gutterbegotten tu'penny syphilitic whore, trash born and to trash you will return. If I speak false in my doubt of you, prove otherwise. You won't. You have neither the honour nor the brains. Now, for the love of fucking christ, just do one already and stop befouling this otherwise good subforum with your mewling shitspeak, because I am fucking tired of it, and tired of you, you crow-born guttersnipe.
 
1-(4-oxocyclohexyl)-2-ethylaminopropan-1-one.png


BETH(ANY)

1-cyclohexyl-1-oxo-2-(1-pyrrolidinyl)pentane.png


JOYCE

1-cyclohexyl-2-aminopropane.png


PHIL(IP)[IANS]

1-(2,4,6-trichlorophenyl)-2-aminopropane.png


CHARLES
 
Propylhexedrine is the second to the last molecule's N-methyl homologue.

1-(5-methoxy-2-oxo-benzofuran-6-yl)-2-aminopropane.png


ELON MUSK
^--one of the coolest names I can think of

1-(2-oxobenzofuran-6-yl)-2-methylaminopropane.png


LEON SANFORD

1-(1-acetyl-indole-3-yl)-2-dimethylaminoethane.png


HARRY HOUDINI

GANNON --> 1-acetyl-4-OH-DMT
LEE --> psilocin / psilocybin
MIKE --> 4-OAc-DMT (best iv'ed)

Houdini and Gannon are there to skirt legal issues, much like ALD-52 does with LSD. The last two are just trivial nicknames of mine.

"The MIKE stands for money and the D is for diamonds."--The Beastie Boys.
 
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My bad, I had missed it's being the primary amine homolog of propylhexedrine. I was damn tired when I wrote that, and just recovering from a nasty stomach virus.
 
No Worries!

(2S)-N-hydroxy-1-phenyl-2-methylaminopropane.png


FRENCH MONTANA

"I Will Raise My Hands To The Mountains From Whence My Salvation Comes."--The Bible.

This one--O-acetyl-bufontenine--is for IV use.

1-(5-acetoxyindole-3-yl)-2-dimethylaminoethane.png


NATHAN

Not completely convinced this next one, 2-des-methoxy-DOC, is active.

1-(4-chloro-3-methoxyphenyl)-2-aminopropane.png


SEAN

1-(3-methoxy-4,5-methylenedioxyphenyl)-1-(pyrrole-2-yl)methanone.png


DREAM SURREAL

1-(3,4,5-trimethoxyphenyl)-1-(pyrrole-2-yl)methanone.png


NIGHT VISIONS

1-phenyl-1-(pyrrole-2-yl)methanone.png


RIDGEVIEW (weak stimulant)

1-(3,4,5-trichlorophenyl)-1-(pyrrole-2-yl)methanone.png


X-RAY OJOS

1-(isobenzofuran-5-yl)-2-methylaminopropane.png


DAN(IEL)

1-(7-bromo-isobenzofuran-5-yl)-2-aminopropane.png


NICHOLS
 
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OAc-bufotenine might be more active or easily absorbed than bufotenine itself. I'd not reccomend it however, bufotenine in my experience is active, but very,very rough in terms of bodyload.
 
I don't think 2-benzoyl-pyrrolidine is active as a stimulant, unfortunately.
 
That is a pyrrole, not a pyrolidine,
Anyway, pyrole N is not basic as the lone pair is imbued as a part of aromatic ring system.
 
Ok, so then, maybe make these next two with dimethyl amines instead of pyrrole or pyrrolidine?

1-(1-pentyl-4-hydroxy-indole-3-yl)-1,2-dioxo-2-(pyrrole1-yl)ethane.png


WAYNE

1-(1-pentyl-4-hydroxy-indole-3-yl)-1,2-dioxo-2-(pyrrolidine-1-yl)ethane.png


FLOYD


Am quite sure I was telepathically high on

1-(3,4-dichlorophenyl)-1-(pyrrole-2-yl)methanone.png


WILLING WAY

the morning of my spinal tap last spring. It was very, very peaceful. Don't hate me because I can be telepathic please.
 
Some points:

1.If you want cannabinoid activity, remove the OH from WAYNE and FLOYD,
Or change it to OMe, or they will be absense of CB1/2 activity.

2.WAYNE is quite unstable to acidic environment, i think even pH5-6 aq. workup will dealkylate the pyrrole.
Maybe the phenolic OH itself is able to autocatalyse this reaction in polar solvent already

3.Both seems to not withstand vaporization tho, if administration is done at all, they seemed to withstand less than 100 C due to the nature of that “oxalyl” type, prone to degrade to carbon monoxide, idk about your molecules, but similar molecules with this indole,CO,CO,aryl bridge decomposes at like 45C-70C so i had to workup in ice bath. (I was synthesis polyamine coupling agent at the time)
 
Ok, thanks, Pomzazed. I need to do more basic and hands on research and am, in fact, starting chemistry graduate school Tuesday. So wish me luck, my friends, good night, to quote Morrissey. How gay is that?
 
1-(indole-3-yl)-1-(pyrrole-2-yl)methanone.png


ALLISON

1-(indole-3-yl)-1-(pyrrolidin-2-yl)methanone.png


WONDERLAND

If either of these two skeletons are active, then dozens of things can be done at the 1, 2, 4, and 5 indolylic positions, just to name a few.

Next Battle Be TiHKAL. Put It On The Platter--Wu Tang Forever, circa 1997 AD.

Yes, Sir, Mister Method Man.
 
Limpet_Chicken, this thread and prior excessive posting of random analogues is obviously a joke, perhaps a sarcastic joke on the "I like to draw random molecules" thread. Some of the structures posted there were hilarious, but still, the point of the other thread, despite it being in NPD forums, was to be a place for light-hearted discussions on possible analogues of existing psychoactives for people who have knowledge on drug design or are just amateur hobbyists, a place to share ideas where people might learn some interesting facts without necessarily having to dive deep into chemistry or pharmacology. So let it be. It makes me wonder why this thread is still alive considering how time consuming drawing these structures and coming up with random names for them must be overall, but I happen to kill time with useless activities too, so I'm not judging. ;D
 
Dresden, i am not keen about tryptamines, so wait for ppl who is better on this subject.

Alisson seems to be an aryl-receptor ligand tho, but i dont think it will do anything besides activating more enzymes responsible for aromatic oxidation (epoxidation, hydroxylation) and maybe possible acting as xenooestrogen.

Wonderland may be active (unsure, wait for tryp people) but seems to be sucky in effect if it is. (See, lucigenol, for reference)

Anyway; good luck in your chemistry studying!
If you are open-minded about the topics, you will find out it has much a vast, vast more interesting topics apart from neuroacgive molecules. This subject is exceptionally wonderful! This is also why I like it, chosen it as my main during my university times.

And I am not regret about it, i feel glad I doing so.
Playing Lego is fun, especially when your pieces are atoms!
 
A pretty bad joke,pomzazed, and the really annoying thing is the OP is obviously a liar.

Look at him say he is just starting to learn basic chem, then further back, claimed to be an 'established drug designer' whatever that is. I saw through through it and called him out, to give an explanation of his statements, only to be told to fuck off.

So yes I'm annoyed, because the OP is full of shit and a liar.
 
Pomzazed, what are the structural requirements for aryl hydrocarbon receptors? an agonist at that target would be bad news thats for sure.
But you spotted it, I didn't, not sure of the structural requirements of aryl hydrocarbon receptor ligands.
 
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