Not gonna lie guys, you have put me down a bit. Here I am, got some pure MDMA from the glorious internet (if I had this access to all the different drugs back then OMG) and MDA, and have had it about a year, waiting like a fine bottle of Champagne to open up on a good day. Well that time is near, and I must say, I am worried.
I was Rolling starting in 2000. Back then man it was amazing, the culture, music, all of it. When I went to college in 2003, I rolled a few times but the pills got dirtier and dirtier with worse come downs and hangovers. So I stopped
I remember the last time I rolled in 2006, at Junkie XL, in ATL. My sister had me up to hang out and roll, and they were fairly new to the scene wheras I am a veteran. The way they did it was odd. They wanted to re dose all night long, I gave up my last roll for my sister. I was taught to take 2 pills then in an hour or 2 take another or maybe 2, but then after that its over. let it go. It was just different, I realize people were doing that before, but it was new to me.
There can only be a few things here. Isomeric differences: with the S-isomer being much more active, looking at PihKAl the R isomer is active but less so, and the experience is similar, but not as sparkly. There should not be any major difference in the lasting hangover, if anything, the more active S-Isomer should be worse since it drains Serotonin much more readily.
Then there are by products in the synthesis, as we all know the differing substiution patterns to amphetamines are pretty much all active, with methylenedioxy compounds probably in the list of impurities found in the endpoint, and also would probably ride along with in the recrystallizations. The only way to get real super pure product reliably is chromatography (do the dutch labs do this?)
My issue with this is with so many people have Marquis tested these things (is this mostly with pills or also powder/crystal?) Marquis can be fooled, but it cant be the rule, rather the exception. Now if you get marquis tested product that turns black/purple immediately, it can safely be said to be high yield. Not many impurities are active in that low of concentration.
I feel that if the synthetic pathway has changed, the issue is a preference for the R-Isomer (remember Shulgin used Racemic MDMA most of the time). So the preference may be fairly high. The issue with all these negative reactions in the following days I feel is probably misuse and over use of the drug.
Or we are getting old... but again, Shulgin and his colleagues werent spring chickens when they tool MDMA.
I hope I aint disappointed when I get the chance to take my MDA/MDMA rolls!
Edit: As someone who has worked in the chemical and pharmaceutical business a very long time, GMP/GLP, albeit slow and tedious as shit is indeed a good thing and brings traceability and accountability to pharmaceutical companies. It is there for a reason.