Mind-Expansion
Greenlighter
- Joined
- Jan 13, 2018
- Messages
- 21
Hey guys,
First of all I want to clarify that GHB was not meant to be abused as date rape drug or as a 24/7 intoxication. If used responsible, it does neither lead to tolerance nor withdrawals. The FDA actually approved GHB to treat narcolepsy. It's usually dosed twice at night at 4.5 grams. Compared to other depressants like benzodiazepines, GHB actually increases sleep quality.
Here are some studies:
There was a doubling of GH secretion, resulting from an increase of the amplitude and the duration of the first GH pulse after sleep onset. This stimulation of GH secretion was significantly correlated to a simultaneous increase in the amount of sleep stage IV. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508244/)
Unlike most synthetic hypnotics, GHB increased delta sleep and did not suppress REM sleep. It shortened the REM sleep latency and shifted REM sleep into the first third of the night. On one occasion it induced a sleep onset REM period which was experienced as an attack of sleep paralysis. Withdrawal was simple; there was no REM sleep rebound and sleep patterns immediately returned to their pre-drug form. Its major clinical drawback was its short duration of action: its hypnotic effect lasting only 2 to 3 hr. We suggest that GHB may serve as the prototype for a new class of hypnotic compounds derived from natural sources and capable of activating the neurological mechanisms of normal human sleep. (https://www.ncbi.nlm.nih.gov/pubmed/192353)
It's almost perfect except its short half life. But then I discovered the following:
It is possible, that, after entry into the cell, the compound ethyl 4-acetoxybutanoate of the invention slowly hydrolyses to form gammahydroxybutanoate or a similar compound in situ, to exercise the therapeutic effects thereof over a longer period of time. In any event, it has been found that ethyl 4-acetoxybutanoate has a much longer lasting effect, at equivalent dosage levels, than gammahydroxybutanoate. This makes it a far more effective treatment for narcolepsy than anything heretofore available. Indeed, the effect is so markedly longer lasting that ethyl 4-acetoxybutanoate shows potential for treatment of patients having conditions or disorders where gammahydroxybutanoate is of little or no use. In cases of chronic insomnia, for example, sufficient dosages of the present compound can be administered to maintain sleep throughout the night, without incurring the development of tolerance or withdrawal side effects. Currently available chemotherapeutic agents will not do this. (http://patents.com/us-4599355.html)
Unfortunately, I'm not a chemist. But this would be the ideal sleeping pill.
First of all I want to clarify that GHB was not meant to be abused as date rape drug or as a 24/7 intoxication. If used responsible, it does neither lead to tolerance nor withdrawals. The FDA actually approved GHB to treat narcolepsy. It's usually dosed twice at night at 4.5 grams. Compared to other depressants like benzodiazepines, GHB actually increases sleep quality.
Here are some studies:
There was a doubling of GH secretion, resulting from an increase of the amplitude and the duration of the first GH pulse after sleep onset. This stimulation of GH secretion was significantly correlated to a simultaneous increase in the amount of sleep stage IV. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508244/)
Unlike most synthetic hypnotics, GHB increased delta sleep and did not suppress REM sleep. It shortened the REM sleep latency and shifted REM sleep into the first third of the night. On one occasion it induced a sleep onset REM period which was experienced as an attack of sleep paralysis. Withdrawal was simple; there was no REM sleep rebound and sleep patterns immediately returned to their pre-drug form. Its major clinical drawback was its short duration of action: its hypnotic effect lasting only 2 to 3 hr. We suggest that GHB may serve as the prototype for a new class of hypnotic compounds derived from natural sources and capable of activating the neurological mechanisms of normal human sleep. (https://www.ncbi.nlm.nih.gov/pubmed/192353)
It's almost perfect except its short half life. But then I discovered the following:
It is possible, that, after entry into the cell, the compound ethyl 4-acetoxybutanoate of the invention slowly hydrolyses to form gammahydroxybutanoate or a similar compound in situ, to exercise the therapeutic effects thereof over a longer period of time. In any event, it has been found that ethyl 4-acetoxybutanoate has a much longer lasting effect, at equivalent dosage levels, than gammahydroxybutanoate. This makes it a far more effective treatment for narcolepsy than anything heretofore available. Indeed, the effect is so markedly longer lasting that ethyl 4-acetoxybutanoate shows potential for treatment of patients having conditions or disorders where gammahydroxybutanoate is of little or no use. In cases of chronic insomnia, for example, sufficient dosages of the present compound can be administered to maintain sleep throughout the night, without incurring the development of tolerance or withdrawal side effects. Currently available chemotherapeutic agents will not do this. (http://patents.com/us-4599355.html)
Unfortunately, I'm not a chemist. But this would be the ideal sleeping pill.