N&PD Moderators: Skorpio | thegreenhand
The opioid receptors. Cannabinoid receptors, NMDA, AMPA.
amphetamine is analgesic-sparing
Yes, it augments the analgesic effect of opioids. When taken alone, it increases pain tolerance.Meaning they synergize with analgesics?
Yes, but nociceptors are not ligand-gated ion channels.^Well, there are ionotropic and metabotropic receptors, are there not?
"and friends" - I chuckled from how you worded that.Oh yeah, the Na+ channel that's blocked by lidocaine and friends is also a good analgesic target.
Yes, it augments the analgesic effect of opioids. When taken alone, it increases pain tolerance.
Please describe at as specific a quality as possible.
Every pain-sensing nociceptor, although that "-ceptor" suffix is a bit of a misnomer since those are all ion channels.
I believe some morphine patients have reported that they still feel the pain but simply care less about it, oddly.