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How High Are You? v. Everyone Knows You're High And You'll Feel Like This Forever

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Chilling off 30mg Morphine 15mg Oxy not nodding but good enough for shit I gottta do tonight
 
Blah, morning wasn't the most pleasant experience.. Then I popped 6mg Lorazepam, slammed a few beers, and booted around 2.5mg sub, that got the nerves down. Then I laid in bed enjoying my 2 dawgs company as they napped. As of now, I don't feel bad, well aside occasionally yakking from nausea, though that is not uncommon coming off amps and back to the chill side of life. 1mg Lorazepam + 70mg Nitrazepam + 90mg Phenobarbital, now it's time to replenish my body with fast food and dr pepper.
 
ykm420 said:
Blah, morning wasn't the most pleasant experience.. Then I popped 6mg Lorazepam, slammed a few beers, and booted around 2.5mg sub, that got the nerves down. Then I laid in bed enjoying my 2 dawgs company as they napped. As of now, I don't feel bad, well aside occasionally yakking from nausea, though that is not uncommon coming off amps and back to the chill side of life. 1mg Lorazepam + 70mg Nitrazepam + 90mg Phenobarbital, now it's time to replenish my body with fast food and dr pepper.
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Just got xan val and lor andcan't wait to retry the lorazepam this post has me convinced
 
Just did an 8mg D but it made the pain come down to a really nice level so I got a bunch of shit done that I haven't been able to do for a while. So not only am I high on dilly but I'm fucking high on life and achievement man
 
TheRapperGoneBad said:
Just got xan val and lor andcan't wait to retry the lorazepam this post has me convinced
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Atta blood, BOOIIIZZEEEEE, staying in the cut yadadamean? BLLLLLLLLAAAAAAATTTTTTT!
Goddamn, I'm higher than a Georgia pine.. Just need red wine. Off some real T, does anyone like wine? I personally think it tastes god awful. Terrible hangovers, last two times I drank it was eating mad grips, bringing a bottle of my madres expensive bs wine to my broj's, we chugged it (Already shithoused before I arrived, as were they) then we slap boxed.. I got one straight to the fucking ear, then skurted off on his ass with a two peace, then hugged it out. Next round it was broj #2 vs broj #1, which the first hombre definitely had hands.. Next thing I know he gets the fuck slapped out of him and got merked by a viscious left handed power-house, and fell the fuck down..
--
Then I got piss drunk on Bombay, drank a buncha wine with a sesssssy broad, I muff dived, got no remuneration for my snake tongue, and passed the fuck out after 15 minutes of omnomnomnom.. Needless to say, I woke up feeling like an indian tomahawked my front head. Worse than drinking 3 40's of 211, which is up there in my worst hang-overs of all time.
 
Wine sucks ass ykm I agree. At least you got some quality muff diving sounds like. I hate them hangovers too, rival cheap licker honestly.

I'm happily buzzed, still HIGH since oramorph lasts fuckin forever, gotta bounce out now but I'll be back later tonight on some bennies I'm sure.


Happy Friday fuckers =D and enjoy ya twip phatty!!
 
phatass said:
twippin' =D
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Watcha indulge in my dinnerplate broj?! I'ma guessing.. AL-LAD + EPH? :D Maybe some noids' to kick it up 14 notches, NASA, PA has lift off! Houston, we have no problems, just smoove sailin' sherrie!
EDIT! Oramorph! /Envy <3!
Double edit! 1P-LSDiesel, try it yet hombre? :)
 
90mg hydrocodone, 30mg temazepam, 2mg clonazepam, 30mg cyclobenzaprine, and the following potentiators: 150mg clotrimazole, 500mg ciprofloxacin, 800mg cimetidine, large amount of grapefruit juice, 150mg diphenhydramine, and 300mg daily bupropion/Wellbutrin (prescribed for depression/Bipolar disorder). I feel like I have had more like 150mg+ hydrocodone.

About to smoke some weed.

Hydrocodone is metabolized mostly by CYP-450 3A4 but also by 2D6 (at least from the information I have gathered).
Clotrimazole is a strong or moderate inhibitor of 3A4, cipro is either a moderate or strong 3A4 inhibitor, cimetidine is a weak 3A4 and 2D6 inhibitor, bupropion is a strong 2D6 inhibitor, and grapefruit juice contains a moderate 3A4 inhibitor. This is how strong, moderate, and weak inhibitors are defined:
A strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values, or more than 80% decrease in clearance.
A moderate inhibitor being one that causes at least a 2-fold increase in the plasma AUC values, or 50-80% decrease in clearance.
A Weak inhibitor being one that causes at least a 1.25-fold but less than 2- fold increase in the plasma AUC values, or 20-50% decrease in clearance.
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I don't think all drugs metabolized by these enzymes are affected as strongly though.

I have seen conflicting info on whether Cipro is of strong or moderate strength - some lists do not specify its strenght but I read a study showing a significant increase in side effects such as respiratory depression when taken with hydrocodone. Oral clotrimazole+hydrocodone is listed as a major interaction with the drug interaction checker and is in a class of drugs that contain a number of strong and moderate 3A4 inhibitors.

I took most of the inhibitors at least an hour before the hydrocodone. It makes the effects much stronger and much longer lasting. Diphenhydramine and many other antihistimines increase the effectiveness of opiates by 15-30%. You can get clotrimazole OTC - it is in cream for athlete's foot and nail fungus. Whether or not you are willing to eat cream meant to be applied externally is up to you.

For best results potentiating hydrocodone, you probably want to combine a strong 3A4 inhibitor with a strong 2D6 inhibitor if the drug interaction checker is correct, but strong 2D6 inhibition may decrease effects by slowing or stopping conversion to hydromorphone. Maybe the best way to do this is to inhibit 3A4 as completely as possible and not worry about 2D6 (but I need Wellbutrin/bupropion, so I can only try quitting it a few days then seeing if things work better with everything but the 2D6 inhibitors) and an antihistimine. Adding UGT2B7 inhibitors will possiblyly increase the effects noticeably by slowing breakdown of the active metabolite hydromorphone which may be responsible for nearly half of hydrocodone's effects.

I could be wrong. 3A4 inhibition keeps hydrocodone from being metabolized as fast and increases peak levels (not sure if all inhibitors help) but this slows conversion to hydromorphone. In one place I read over, it says maybe about 53% of the effects of hydrocodone are from hydrocodone itself and about 46% from the active metabolite hydromorphone (I do not know how accurate that info is due to the source) and that 2D6 inhibition prevents hydrocodone from being metabolized to norhydrocodone but that is a drug forum website and a scientific study says it is the other way around. Here is where I read that above info: https://www.drugs-forum.com/forum/showthread.php?t=236374

I'll go by a scientific study which seems more reliable and the information seems more like what I have read in the past. The study says 2D6 is responsible for converting it to hydromorphone and it is 3A4 that metabolizes it to norhydrocodone, a very weak opioid. The scientific study says hydromorphone only contributes modestly to the effects of hydrocodone.It is over the topic of conversion to hydromorphone and 2D6 enzyme. It said adding a strong 2D6 inhibitor, quinidine, produced just minor and inconsistent effects and hydromorphone contributes only slightly to hydrocodone's abuse potential. http://jpet.aspetjournals.org/content/281/1/103.full.pdf
But then I see what seems to be a professional source saying hydrocodone is metabolized completely by 2D6 - does not seem to be the case from many other sources, all that disagree - all others say 3A4 and 2D6 are involved.

Hydromorphone can be potentiated with UGT2B7 inhibitors. I only see four listed here: Ketoconazole (also a strong CYP450-3A4 inhibitor), Valproic acid, Silybum marianum, and Valerian root: http://www.pharmacologyweekly.com/c...rbs-substrate-inhibitor-inducer#UGTInhibitors

Maybe the best way is a strong and multiple moderate and weak inhibitors of 3A4 to inhibit the enzyme as fully as possible and maybe a weak or moderate 2D6 inhibitor since your hydrocodone levels should be high much longer and 0 you won't need to convert that to hydromorphone very fast. Adding UGT2B7 inhibitors might help and I am going to try it.
 
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