dopamimetic
Bluelighter
Since I got diagnosed with inattentive ADD and tried the meds available as well talking with other patients, and being not satisfied with methylphenidate and d-amphetamine (or their side effects), I have thought about possible "better" treatment options.
Pemoline being the one that interests me at most. Wiki describes that it is not a sympathomimetic or NDRI / NDRA but instead working as a surrogate for dopamine, not affecting endogenous dopamine (reminds me of dopamine agonists, but they don't seem to be that effective at all.. outside of treating parkinsons') - requiring some time for effects to become evident, like with antidepressants, and not having sympathomimetic side effects of course. Then I've read that one could nevertheless stay up for two days or more with Pemoline. And of it having nootropic like effects, maybe especially in the magnesium salt form.
They say it has been pulled off the market due to some cases of liver damage. While this is serious of course, it wonders me how serious it really was since there are just around twenty cases out of millions of patients and I guess they did not have liver enzymes monitored, as that side effect was not known back then. Thinking of other, widely used pharms like sodium valporate (just as an example) or that nasty new Agomelatine that are known to be hard on the liver and get prescribed nevertheless.
Then there are of course the more or less related aminorex chemicals. I have done that 4,4'-dimethylaminorex many times in low dosage, and while its effects are heavily serotonergic, it has some distinctive "sharp-minded" clearness to it that 4-MAR is said to have as well - and regarding the (acute) subjective side effects, this category of chemicals seems interesting to me too.
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So, what I'm wondering about now is, has Pemoline really been such a top ADHD med / superior to what's available today or is it overhyped and comparable to the amphetamines? Could it be that the liver damage was not the only reason to pull it?
Are there papers on other oxazoline derivates that are dopaminergic like pemoline and possibly safer to the liver?
Pemoline (2-amino-5-phenyl-1,3-oxazol-4[5H]-one) and Aminorex (5-phenyl-4,5-dihydro-1,3-oxazol-2-amine)
Pemoline being the one that interests me at most. Wiki describes that it is not a sympathomimetic or NDRI / NDRA but instead working as a surrogate for dopamine, not affecting endogenous dopamine (reminds me of dopamine agonists, but they don't seem to be that effective at all.. outside of treating parkinsons') - requiring some time for effects to become evident, like with antidepressants, and not having sympathomimetic side effects of course. Then I've read that one could nevertheless stay up for two days or more with Pemoline. And of it having nootropic like effects, maybe especially in the magnesium salt form.
They say it has been pulled off the market due to some cases of liver damage. While this is serious of course, it wonders me how serious it really was since there are just around twenty cases out of millions of patients and I guess they did not have liver enzymes monitored, as that side effect was not known back then. Thinking of other, widely used pharms like sodium valporate (just as an example) or that nasty new Agomelatine that are known to be hard on the liver and get prescribed nevertheless.
Then there are of course the more or less related aminorex chemicals. I have done that 4,4'-dimethylaminorex many times in low dosage, and while its effects are heavily serotonergic, it has some distinctive "sharp-minded" clearness to it that 4-MAR is said to have as well - and regarding the (acute) subjective side effects, this category of chemicals seems interesting to me too.
--
So, what I'm wondering about now is, has Pemoline really been such a top ADHD med / superior to what's available today or is it overhyped and comparable to the amphetamines? Could it be that the liver damage was not the only reason to pull it?
Are there papers on other oxazoline derivates that are dopaminergic like pemoline and possibly safer to the liver?
Pemoline (2-amino-5-phenyl-1,3-oxazol-4[5H]-one) and Aminorex (5-phenyl-4,5-dihydro-1,3-oxazol-2-amine)
)? Well, whoever made that edit is mistaken, as the compound interacts strongly with DA and NE transporters, most likely reversing transport. It is really a "vanilla stimulant".