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I Like to Draw Pictures of Random Molecules

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Ar 2 D2 wont work, argon of course being a noble gas, and will not easily bond with anything at all. Otherwise, 3CPO looks like an actually promising molecule... although since you added the alpha methyl it isnt really 3cpo.


But I am just being a real party pooper, I guess its all fun anyway, although it would be nice if some of those were active too!
 
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Just made my take on an efavirenz analogue - Although, I just realized it really resembles a psychedelic phenethylamine, analogue'd or not.

qQiS5Lv.png
 
thenightwatch said:
naw he had it right... in shulgin's nomenclature, "3C" denotes a molecule with the 3,4,5 substitution pattern and an alpha carbon. 3C-E, for example, is 3,5-dimethoxy-4-ethylamphetamine
Click to expand...

Aw ok, I always thought using the C was meaning that it wasnt an amphetamine, but I haven't read a whole lot of shulgin's work (although I plan to.)
 
its because of the order he came up with everything in... he did the 3,4,5-subbed phenethylamines first (a la Mescaline), then moved his way to the 2,4,5-substituted amphetamines (DOx). it wasn't until after he played around with those two classes that he started making the 3,4,5-amphetamines and the 2,4,5-phenethylamines. so, "2C" stands for the alpha-desmethyl version of its DOx cousin, and "3C" stands for the alpha-methyl version of its Mescaline-analogue cousin.

so 2C-E is the phenethylamine version of DOET, and 3C-E is the amphetamine version of Escaline (3,5-methoxy-4-ethoxyphenethylamine).
 
thenightwatch said:
its because of the order he came up with everything in... he did the 3,4,5-subbed phenethylamines first (a la Mescaline), then moved his way to the 2,4,5-substituted amphetamines (DOx). it wasn't until after he played around with those two classes that he started making the 3,4,5-amphetamines and the 2,4,5-phenethylamines. so, "2C" stands for the alpha-desmethyl version of its DOx cousin, and "3C" stands for the alpha-methyl version of its Mescaline-analogue cousin.

so 2C-E is the phenethylamine version of DOET, and 3C-E is the amphetamine version of Escaline (3,5-methoxy-4-ethoxyphenethylamine).
Click to expand...

Yeah, Shulgin's nomenclature wasn't exactly on point (in some parts(F-22? It sounds like a plane!)) but it did give us the basics for future chems. I don't know how I'd have named it (3C-E) though, maybe MA-4-EO? Doesn't have the same ring to it, in all fairness. Props to Shulgin then!
 
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Posted this on a different forum but didn't receive much feedback. Was wondering what you lot thought.

2vwtwzp.png

1-[4-(3-METHYL[1,1-DIPHENYL])-1-methyl-4-piperidyl]AMINOETHANE

DiPhenMethylPipEtAmine; DPMPEA, DPPE

A PCE + Ketobemidone + Desoxypipradrol hybrid which should retain affinity at both NMDA receptors, Mu receptors, and the DAT - for simultaneous, POTENT, DARI + NMDA antagonism + Opioidergic activity in situ.

I realize it might be TOO long lasting...a solution to that which might also enhance mu-affinity would be to add a hydroxyl group at the 1- diphenyl carbon.

This may lower NMDA antagonism though. Shouldn't affect DAT blockade. The keto-piperidine derivative should work as well, ala *etamines.
 
N0 W4RN1NG said:
Posted this on a different forum but didn't receive much feedback. Was wondering what you lot thought.

2vwtwzp.png

1-[4-(3-METHYL[1,1-DIPHENYL])-1-methyl-4-piperidyl]AMINOETHANE

DiPhenMethylPipEtAmine; DPMPEA, DPPE

A PCE + Ketobemidone + Desoxypipradrol hybrid which should retain affinity at both NMDA receptors, Mu receptors, and the DAT - for simultaneous, POTENT, DARI + NMDA antagonism + Opioidergic activity in situ.

I realize it might be TOO long lasting...a solution to that which might also enhance mu-affinity would be to add a hydroxyl group at the 1- diphenyl carbon.

This may lower NMDA antagonism though. Shouldn't affect DAT blockade. The keto-piperidine derivative should work as well, ala *etamines.
Click to expand...

Wouldn't the DARI action also mean that it would have some action on Norepinephrine reuptake? I don't know how I feel about an adrenergic dissociative.
 
Not necessarily, although I see your concern. PCP has quite a bit of DARI action IIRC, but lacks any appreciable NET obstruction.
 
N0 W4RN1NG said:
Posted this on a different forum but didn't receive much feedback. Was wondering what you lot thought.

2vwtwzp.png

1-[4-(3-METHYL[1,1-DIPHENYL])-1-methyl-4-piperidyl]AMINOETHANE
Click to expand...

I like this. However, I think it would wane towards the DRI side rather than being an NMDA antagonist/opioid, it could even step into the anti-histaminergic side. I know too little of this SAR to comment though. If someone does a synth, however, consider me a rather small rodent!
 
benzo analogue of etiz:
cCuZfw1.png


thienodiazepine versions of

alprazolam:
ghJEe3G.png


flunitrazepam:
58hq8Y1.png


few mxe analogues

pcpr mxe
jVdTNJk.png


pcpy mxe:
tObnma7.png


tcp mxe:
UjGlUET.png


tcpy mxe:
x5tnRaP.png


tiletamine mxe:
O8qzkJS.png


thieno lsd:
la4RCKS.png


think any of these would work?
 
I was recently thinking of the thienobenzos to be honest! I went with isoprotizolam. I'm not sure how the sulphur would react with the chlorines though as someone had warned them off to me before, so I didn't go much further. Would they work?

That tiletamine MXE scares me though. I do not like Tiletamine!!
 
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blueberries said:
I was recently thinking of the thienobenzos to be honest! I went with isoprotizolam. I'm not sure how the sulphur would react with the chlorines though as someone had warned them off to me before, so I didn't go much further. Would they work?

That tiletamine MXE scares me though. I do not like Tiletamine!!
Click to expand...

I just posted a few examples of thio/benzo switches, if the chlorine would be the only problem, just use one without it.
Do you have a pic of isoprotizolam? Sounds interesting.


As for the MXE analogues, again, just posted a whole bunch of them. Some may end up good, right? :) It's time for a good one... especially now that MXE is being banned EU wide...
 
Sure here you go:
Y10kFMg.jpg


MXE analogues, I think, are mostly dead in the water, although I wouldn't mind seeing a few with that amine in different substitutions. I've been playing around with the ACH's quite a bit but never drawn them properly (most are in my notebook). The few I have done are above in the "analogues that should produce holes" picture.

IMO ACH's are very fun to design, I mean there are so many ways you can alter them that have just not been tested ('adder', however gave us that backbone - he's definitely a Shulgin-esgue kind of guy!). I could go on all day with ACH analogues but without testing properly I can't find that golden combination. It may be that the golden one is, in fact, MXE and the rest are pure piss. I don't think so though. I mean MXPy looks great, I wonder if subs on that ring would do any good? For the moment there are hundreds that are active but adding subs on the amine ring would square that number.

I've been thinking about 3-Fl analogues a lot, also 4-propylbenzene analogues...I'm thinking a huge change in potency there!
 
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Interesting, here is one for you:
Yo19gOB.png

notice to which it's similar?

MXE analogues idk.. so many possible ones, some might be ok. On the other hand most other ketamine analogues were crap.

Perhaps we'll be able to simulate activity on our pcs one day... would take a lot of the guess work out of making new ones.
Imo 3-meo-2-oxo-pcp would be good, but that's just a feeling.

The difluoroamphetamines/methamphetamines should be good too imo.
Like:
98rpQWh.png


Or fluorinated phenmetrazine analogues like:
FShGCnB.png
 
blueberries said:
What about 2C-N? Given, the bodyload and all that but it worked well as an amp and an nbome. Surely the same must be said for the Phosphorous?
Click to expand...

The difference is Nitrogen forms more stable bonds with oxygen and carbon then Phosphorus does - look at the rapid metabolism of psilocybin.
 
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