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Benzos clonazepam how much is too much?

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panocha_44

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My girlfriend has taken clonazepam in the past as a recreational high. She takes them maybe two to three months apart. The last time she took 2 1/2 2mgs. Now she wants to try 4 pills, she can't really over dose on this amount? Thanks in advance you guys.
 
She won't overdose unless she mixes it with other sedatives.

EDIT: Alcohol is one of the sedatives/depressants that a benzo naive, and anyone really should not mix.
 
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Generally at 4mg, someone without a benzodiazepine tolerance will simply go to sleep.

It is people tolerant to CNS depressants, taking very high doses, that tend to act insane. Although, clonazepam is GENERALLY less sedating than other strong benzo's, so it is easier to "act a fool", if ya know I mean.
And benzodiazepines are actually quite safe on they're own, as others said, it is mixing them with other drugs,(CNS depressants) that spells danger(Will Robinson).
 
Personally I just don't see anything recreational with clonazepam. Sure mg for mg it is a strong benzo but I find its effects to be much more subtle than others.
 
Thanks for the quick replies, besides "act a fool" @ 4 pills @ 2mgs. each, is the worst that will happen to her is passing out? We generally stay at home so she's be safe.
 
No - passing out is not the worst thing that could happen. She could potentially have paradoxical effects, or just a serious kind of "act a fool" - similar to when people are blackout drunk. Some people are just obnoxious and clumsy, others are violent; in any case, she could end up doing some really stupid shit, and she probably won't remember a thing about it the next day. Anyway, if you're with her, then it should be fine - if she was alone, then there would be the possibility that she wanders out and does some real dumb shit - I know several people that have woken up at the police station, bruised, with no idea of what they'd done the night before.

Also, 8mg of clonazepam is a lot, and it has a long half-life, so she will probably still be feeling it the next day - and might get surprisingly fucked up even if she drinks a beer or two tomorrow.

So in summation: there is absolutely no risk of overdose (unless you are mixing other CNS depressants). I have eaten 600mg temazepam in one go, and while I blacked out for a good while, nothing happened. That is equivalent to 15mg clonazepam.
 
^^^ Some good point's some debatable:

Correct: It is common for people who black out on benzo's to have little to no control of know what and when they are doing things for instance, I have heard of numbers of Benzo User's passing out in public / people's front yards...

Also correct, she will be feeling that shit the next day.... Very very long half life.

However the OP does not state the females body weight and 8MG once active is ALOT for someone with no tolerance. Just because you took .6temaz with no effect does not mean the user in this thread cannot be harmed by a smaller dosage.
 
I believe the ld50 off the top of my head would amount to you having to digest 20000 1mg pills, which is pretty impossible. Otherwise I think the max dose that docs script is 20mg.
 
EarthBounded said:
Also correct, she will be feeling that shit the next day.... Very very long half life.

.
Click to expand...

No, that is incorrect. Although the half-life of clonazepam is quite long, the duration of action if a single dose is MUCH shorter.

Generally, with acute dosing, clonazepam has a duration of 6-12 hours, unless an insanely high amount.

People forget that duration if action and half-life are not mutually exclusive; and especially with benzodiazepines, the duration is ALWAYS (usually much) shorter than the half-life.

The idea you could take a single 8mg dose of clonazepam and be high the next day is silly.
And at 8mg, she will most certainly pass out. Again, people who act silly on benzodiazepines are people tolerant enough to stay awake. Paradoxical effects are also unlikely at that dose, as again, the notorious paradoxical effects of clonazepam tend to affect benzo-tolerant people taking higher doses, not people who take benzos once every 2 or 3 months.
 
Um you are actually wrong. if someone was benzo naive taking 8mg of Clonazepam or even someone with a little bit of experience could very easily be high the next day. i remember my first time taking klonopins i took 3mg had zero benzo tolerance and was still high the next day also had bad balance still. i recently took 11mg of klonopin (stupid i know) on a trip to las vegas and dont remember my 2 days there really.
Lorne??? said:
No, that is incorrect. Although the half-life of clonazepam is quite long, the duration of action if a single dose is MUCH shorter.

Generally, with acute dosing, clonazepam has a duration of 6-12 hours, unless an insanely high amount.

People forget that duration if action and half-life are not mutually exclusive; and especially with benzodiazepines, the duration is ALWAYS (usually much) shorter than the half-life.


The idea you could take a single 8mg dose of clonazepam and be high the next day is silly.
And at 8mg, she will most certainly pass out. Again, people who act silly on benzodiazepines are people tolerant enough to stay awake. Paradoxical effects are also unlikely at that dose, as again, the notorious paradoxical effects of clonazepam tend to affect benzo-tolerant people taking higher doses, not people who take benzos once every 2 or 3 months.
Click to expand...
 
Well it certainly depends on the person taking k-pins it can vary with side effects.
 
Lorne??? said:
No, that is incorrect. Although the half-life of clonazepam is quite long, the duration of action if a single dose is MUCH shorter.
Generally, with acute dosing, clonazepam has a duration of 6-12 hours, unless an insanely high amount.
People forget that duration if action and half-life are not mutually exclusive; and especially with benzodiazepines, the duration is ALWAYS (usually much) shorter than the half-life.
The idea you could take a single 8mg dose of clonazepam and be high the next day is silly.
Click to expand...

No it isn't. Duration of action and half-life are not the same, that's true, and the duration of action of a single dose is much shorter. However. 8mg is not a single dose for a non-tolerant person; that is at the very least four times a normal dose, and possibly 16x (for some people they aren't that potent, but for many they are - personally if all I needed was anxiolytic relief, sometimes 0.5-1mg would do the trick even when I had a bit of tolerance, and I'm 6'4").

Duration inevitably increases with the dose. If clonazepam has a half-life of between 18 and 50 hours (highly variable), and let's say we assume this person metabolizes it quickly, in about 20 hours, then in a day's time she will still have 4mg of clonazepam in circulation. Sure, it's not the same as if she'd just taken a new 4mg, but it's not as if your metabolism goes into overdrive and sorts out all of it in the normal 10-12 hours by turning it into inactive metabolites and distributing it to peripheral areas - a lot of that stuff will still be going to your brain.

You don't need an "insanely high amount" for a reasonably long-acting benzodiazepine to still be exerting noticeable effects the next day, and we are seriously talking about a substantial amount for a non-tolerant person. Alprazolam will also miraculously work for longer than the typical 4 hours or so if you suddenly scarf down four Xanax bars without any tolerance. The "returns", if you can call them that, are diminishing in that it doesn't work for twice as long with twice the dose, but I would be surprised if she wasn't feeling it the next day. I'm not saying she'll be fucked up like the night before, but definitely not sober either.
 
Lorne??? said:
The idea you could take a single 8mg dose of clonazepam and be high the next day is silly.
Click to expand...

Clonazepam has an unusually long elimination half-life of 18–50 hours <--- http://en.wikipedia.org/wiki/Clonazepam

The biological half-life or terminal half-life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity, as per the MeSH definition <---- http://en.wikipedia.org/wiki/Biological_half-life

I'm not trying to be rude but DO NOT make pharmaceutical comments based solely on your own opinion, that in turn could harm someone, keep it factual so BL users can make there own choice after research and getting questions answered.

Lorne??? said:
the notorious paradoxical effects of clonazepam tend to affect benzo-tolerant people taking higher doses, not people who take benzos once every 2 or 3 months.
Click to expand...

Paradoxical reactions to benzodiazepines, characterized by increased talkativeness, emotional release, excitement, and excessive movement, are relatively uncommon and occur in less than 1% of patients. The exact mechanism of paradoxical reactions remains unclear. Most cases are idiosyncratic; however, some evidence suggests that these reactions may occur secondary to a genetic link, history of alcohol abuse, or psychological disturbances. <---- http://www.medscape.com/viewarticle/489358_1
 
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EarthBounded said:
Clonazepam has an unusually long elimination half-life of 18–50 hours <--- http://en.wikipedia.org/wiki/Clonazepam

The biological half-life or terminal half-life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity, as per the MeSH definition <---- http://en.wikipedia.org/wiki/Biological_half-life

I'm not trying to be rude but DO NOT make pharmaceutical comments based solely on your own opinion, that in turn could harm someone, keep it factual so BL users can make there own choice after research and getting questions answered.



Paradoxical reactions to benzodiazepines, characterized by increased talkativeness, emotional release, excitement, and excessive movement, are relatively uncommon and occur in less than 1% of patients. The exact mechanism of paradoxical reactions remains unclear. Most cases are idiosyncratic; however, some evidence suggests that these reactions may occur secondary to a genetic link, history of alcohol abuse, or psychological disturbances. <---- http://www.medscape.com/viewarticle/489358_1
Click to expand...

And I'm not trying to be rude, but don't discuss pharmacology with me if the extent if your argument relies on a wiki link!

It is well know that the duration of benzodiazepines is much shorter than the half life, especially with acute doses.

Now of course very large doses can extend the duration, but I never said that *some* effects couldn't linger until the next day, but their is no way that she's gonna be fucking blacked out for 24 hours, and if so, she's likely in need of a liver transplant!

Actually, even reduced hepatic function wouldn't change the fact that benzo's are ultimately redistributed from the CNS to various body tissues, and so with acute dosing, they say "so-long and goodnight" long before the T1/2 would suggest.

As I said, but as you Apparently missed, or ignored, HALF-LIFE IS NOT THE SAME AS DURATION OF ACTION. T1/2 refers to the time it takes for your body to clear roughly half the dose, it is (often) irrelevant to how long a substrate it available to it's target(in this case, the so called benzodiazepine receptors, in the CNS)

I don't have the time, but I suppose ONCE AGAIN I shall post the myriad of literature documenting duration vs half-life for the benzodiazepines. Better yet, read through my posts, as I have covered this several times.

And my "opinion"? Ha!

(And let me please note, again that 8mg clonazepam is a fucking huge dose. Like seriously, it roughly equal to 160ng diazepam, so it can/will certainly have an extended duration...)

But in general? 6-12 hours, acute dosing...
 
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