ro4eva
Bluelighter
If the tinnitus isn't being caused by an inner ear problem, such as Meniere's disease or vestibular neuronitis, then I think the tinnitus is directly caused by the MDMA altering serotonergic inhibitory mechanisms in the prefrontal cortex of the brain. I think this loss of inhibitory mechanisms in the prefrontal cortex is also what is responsible for the feeling of "being able to hear your heartbeat" reported in some MDMA users. These inhibitory circuits in the prefrontal cortex serve to tune out certain ambient elements.
Wow - this is profound in my case, as "being able to hear my heartbeat" is the only symptom which continues to present itself, ever since that reckless day in June 2005.
Over time, my "uncomfortable awareness of my heartbeat" - as I call it - has slowly but surely decreased in intensity, severity, longevity, and frequency. But it's never completely left me.
Zebrafish, would you recommend that I begin taking an SSRI in order to try and get rid of it completely? Perhaps I should have remained on Zoloft for a longer amount of time, back in 2006?
Most people find it hard to believe, and I don't blame them because SSRIs aren't exactly the easiest "anti-depressants" to remain committed to taking on a daily basis for several weeks, months, years, etc. They have some particularly nasty side effects (especially when you first start taking the drug, I find), and a few may be long term, such as issues with achieving and/or maintaining an erection.
Nevertheless, I continue to believe that choosing to use Zoloft for about 8 months back in 2006 aided my recovery.
A thought just popped into my head... Perfect timing too...
Ever since my "bad roll" nearly 9 years ago, there have been (many more) times (than I can count) when, for whatever reason, I decided to use therapeutic dosages of either Diphenhydramine (Benedryl), and also Dimenhydrinate (Gravol) - the later being a mixture of diphenhydramine and a slightly altered form of theophylline, IIRC. The point being that every time that I would be under the influence of diphenhydramine, I quickly began to notice that my "uncomfortable awareness of heartbeat" symptom was noticeably absent.
Eventually, I was surprised to learn that one of - if not - the first SSRIs invented - Fluoxetine (Prozac) - is based on the serotonin transporter inhibitory effect of diphenhydramine. Therefore, it's interesting that you mention the SSRI family as a possible candidate for treating (and perhaps reversing in the long term) prefrontal cortex-related tinnitus, as well as the "being able to hear your heartbeat" symptom which a significant portion of past and present MDMA users claim to be experiencing.
Although to mother nature, the average life expectancy of a human being is nearly nothing to write home about, for a human being who has been dealing with a chronic symptom for about 106 months, it certainly has made me forget how it felt to live without it. Not that I'm expecting any pity, as I am responsible for what has occurred to me.