• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ

Dissociatives The Big & Dandy Diphenidine Thread

I posted this on another forum but I figured I'd post here as well just to add to the collective experience.

So I thought I'd share my experiences with Diphenidine since nobody seems to be talking about it. This is based on four experiences, never higher than 100mg. I'll probably push the dose a little but the magical 150 people talk about seems like a bit much for me. To start this one has almost no euphoria or sense of well-being like many of the arycylohexylamines. WIth MXE you can take a low dose and just relax, enjoying movies and music. With Diphenidine everything seems distant and uninteresting. This is one to take for exploring different states of mind rather than recreation, I'd be very surprised if there was any affinity for SERT or DAT.

The time frame of diphenidine is what makes it difficult, it has a slow come, about an hour without feeling much of anything. Then out of nowhere it all comes on at once. A very powerful dissociation characterized mostly by sensory distortion, a strong buzzing in your head, and amnesia. This state, which I'll talk about a bit more later, lasts maybe an hour tops before devolving into a pretty lucid but still altered headspace. The entire experience resembles a dissociative punch in the face, the rapid onset of the peak leaves you disoriented and confused, combined with the amnesia the second less intense portion is spent mostly wondering what just happened.

Now when I say amnesia I don't mean it in the sense of benzos or alcohol. You can still remember what you were doing and what happened but you can't remember your thoughts, feelings, or even being there really. It feels like you blacked out for about an hour and someone else made up some memories for you to fill in the gaps. It's the kind of drug where I could see myself staring at a wall for 45 minutes without even realizing it. Some people have described this as being similar to a type of "zen state" where you have silenced your inner dialogue but comparisons to becoming a zombie or having a lobotomy also come to mind.

There are no CEVs like MXE or Ketamine but there is the capability for some horrendus sensory distortion. I'm sure all of us are familiar with the "stuttering" effect that can happen with high dissociative doses, the stuttering on diphenidine was to the point where I couldn't tell what was to my left and what was to my right at times. To summarize your senses become a jumbled confused mess and your subconscious seems to take control almost like an emergency autopilot as your conscious mind fails to connect with even your thoughts or emotions.

Next I want to talk about the "buzzing" I've experienced. With many drugs there is an associated physical feeling in your head. Diphenidine is one of those, the only way to describe it is a buzz especially since there is a literal buzzing sound which I can only assume is some kind of tinnitus warped by the sensory distortion. This buzz is very similar to the one that I get on 4-MeO-PCP but beyond this superficial aspect the chemicals are nothing alike. Infact the headspace doesn't resemble arylcyclohexylamines at all, when described they both sound like dissociatives but they *feel* completely different.

Finally I want to mention the combos with MXE I've done. The "boring" phase after the peak tends to last for a really fucking long time and so sometimes I've found myself taking bumps of MXE during it to spice it up a bit. Both times have resulted in a very deep but lucid hole from relatively small amounts of MXE. The hole resembles some of my early MXE holes but without the overwhelming confusion. The visual aspect is more muted than a standard M-hole, there are no otherworldly visions conjuered but there are some rather abstract psychedelic CEVs.

I hate to simply reiterate what everyone else has said before but this is something worth taking a handful of times at most. It certainly gives you some interesting data points in the spectrum of altered states and I would be VERY interested to see it's binding affinities, but it's not one that I can see myself coming back to for mind blowing experiences and certainly not one for recreation.

I will give it one or two more tries, maybe 110mg and once again mixed with noopept. The second phase is a good launching point for other dissociatives but I also found the mix quite physically draining.
 
This stuff is complete mind-fuckery.

My dissociative experience: Methoxetamine pretty much since it came out but don't do it too often anymore, I've done quite a bit of Ketamine, and tried 3-MeO-PCP and 4-MeO-PCP about 5-10 times each.

I tried this last night, about 4-5 hours after 5mg of 3-MeO-PCP, some sake and 6 beers.

Since I have a tolerance to NMDA antagonists I figured a good starting dose for myself would be 95mg. My girlfriend and I both came home from a party and figured we'd end the night off trying this as we'd just received some this week. We both did the same amount and both have close to the same tolerance towards NMDA antagonists, but her body reacts differently to it as she gets motion sickness/dizzy from mxe/ketamine fairly easy, whereas I have pretty much never in my life felt dizzy or sick from either.

We both parachuted 95mg at the same time, and as I swallowed mine I noticed that it tore open a bit because I could taste it instantly (tastes like pharmaceutical vomit fyi).

I don't remember a whole lot after that other than this morning I have slight memories of being in my house with a lot of different people (even though it was just us two), and being very confused and mind blown.

My girlfriend barely felt anything other than it kept her up for two hours. But from what she said, 5 minutes after taking it I started feeling it, and I just sat on my couch for 2 hours with a blank/terrified look on my face, completely unresponsive. I apparently noticed her and would look at her when she talked to me but I wouldn't say anything back. That's pretty normal for me when I K-hole, so I suppose I would kind of relate this to a K-hole. After 2 hours I became sober enough to start saying what the fuck and holy shit over and over a again for what she says felt like half an hour; but she says her time perception was a bit off as well from taking it so she's not quite sure.

But as I started slowly coming back to reality I was talking about how I figured the world out, but couldn't explain anything beyond that. She asked me what happened but I just kept saying what the fuck, and holy shit. She went to bed once I started to seem kind of normal as she wanted to make sure I was okay, and apparently even after she went to bed she could hear me saying what the fuck and holy shit in the living room.

That's pretty much all I know. All I remember now is having my mind completely blown at some point last night and feeling like I wasn't even in my own house, but somewhere else in the world with random people. It felt almost salvia-esque in a way. Normally I can't remember anything when I K-hole so I would relate it more so to Salvia than Ketamine for myself personally.

This is straaaaaaange shit. And that's coming from someone who is very used to strange things lol. I basically fell right off the end of the world.

Will be trying again at a lower dosage; I'm thinking 80mg should be less confusing. Also I'm assuming that the tail end of 5mg of 3-MeO-PCP and alcohol had an effect on my trip so we'll see.
 
3-MeO-PCP seems to have some very intense interactions with other dissos, and with psychedelics. Its total duration is much longer than 5 hours, so it will still have been very much active - I've found it significantly deepens Ketamine, MXE and Ethyl-Ketamine experiences in a very unique way, so I expect it had a profound influence on the Diph hole. Very interesting mention of the combo, Mung. Wish I could still get hold of 3-MeO to try it myself!
 
IV 50 mg diphenidine and 50 mg MPA

My first post on Bluelight (been reading for 5+ years now) is a kind of a warning or small trip report. I had a really scary experiece with diphenidine today. I've used most the common dissociatives (Ketamine, MXE, Nitrous, 3-MeO-PCE, 3-MeO-PCP and ether) a lot and feel familiar with all of them. Today - under the influence of various benzos and on 45 mg mirtazapine daily - I decided to IV 50 mg diphenidine and 50 mg MPA in the same shot.

Not a good idea. I went straight to dissohell, I instantly lost connection with with the normal world and my body transformed into extremely weird forms. The left arm, where I had just shot the mixture transformed into a wavy shape, double its normal size. Heart rate doubled and I got scared shitless that I had some kind of reaction to the shot mutilating my arm. As I feared for my life I instantly called for an ambulance, slurring my name and address. By the time the paramedics had arrived I had regained control of myself, so they just monitored my vitals for like half an hour while I returned to a sober state and explained the pharmacology of diphenidine and MPA. After a while my vitals returned to expected from the MPA (high BP) and I refused to go to the hospital for overnight monitoring (despite adviced to do so from the doc they called), as I now felt I could handle myself and actually felt quite sober. After a long talk with the paramedics about changing my habits they finally left. Scary as hell though, I'd advice all of you not to go beyond 25 mg diphenidine IV and don't mix it with substantial doses of MPA.

Just a warning. Stay safe!
 
Last edited:
Glad you're ok. Have you tried other roas for diphenidine? If you have, how do the doses compare between them and iv for you?
 
Phew, good to hear you're alright gaba. I had a scary experience (high BP/temp/seizure) with a high dose of Methoxphenidine recently, and that on top of your report suggests to me that these two compounds are dangerous to combine with other dopaminergic drugs. Diphenidine seems to have significantly lower affinity for dopamine sites than the Methoxy derivative, but your report has further convinced me that serious care must be taken when combining either of them. Hazarding a guess, I don't think your experience had much to do with your ROA.
 
Glad you're ok. Have you tried other roas for diphenidine? If you have, how do the doses compare between them and iv for you?

Phew, good to hear you're alright gaba. I had a scary experience (high BP/temp/seizure) with a high dose of Methoxphenidine recently, and that on top of your report suggests to me that these two compounds are dangerous to combine with other dopaminergic drugs. Diphenidine seems to have significantly lower affinity for dopamine sites than the Methoxy derivative, but your report has further convinced me that serious care must be taken when combining either of them. Hazarding a guess, I don't think your experience had much to do with your ROA.

I've tried intranasal, rectal and just swollowed a gelcap with 50 mg. Sort of idiotic to IV dissociatives as the "hit" can be quite scary even though I enjoy the hit from ~25 mg Ketamine or MXE IV. The reason I did 50 mg IV was the very pleasant and managable experiences I've had with 20 mg diphenidine + 25 mg MPA + 15 mg zolpidem IV and hence had an urge to try i higher doser. Being on lots of benzos yesterday made me reckless. I should have threaded easier, like upping to 25 mg dipenidine instead. As pointed out earlier it appears to have a non-linear and quite steep response curve.

Rectal and nasal ROA definately has a lot lower BA, longer and softer onset and seems a lot safer.

I came to think that I almost when into hypertensive crisis, with a BP of up around 120/160 for about half an hour (I closelý watched the monitor the whole time). No actions where taken to lower my BP though other than me taking 40 mg propranolol after the paramedics left. They admitted that I had a lot more pharmocological knowledge than them, so I didn't talk to them about taking propranolol. The doc they called apperently did not recommend any measures to lower my BP, despite alarming values. I should also add that my EKG looked like a childs drawing for the first 10 mins of monitoring, but then returened to normal sinus rythm. BPM was 80-90 all the time (as expected from the MPA and maybe mirtazapine and me being scared), but that wasn't considered a significant problem by the doc or paramedics. I should add that my oxygen saturation never went lower than 97%, and I had no chest pains or breathing problems.

Big thanks for the caring words, black53 and Dioxy, despite not knowing any of you from before. <3
 
gabafish, so how stronger would you put iv as opposed to other roas? 4x oral?

>Being on lots of benzos yesterday made me reckless.
Believe me, I can relate to doing stupid stuff on benzos :D

>Big thanks for the caring words, black53 and Dioxy, despite not knowing any of you from before.
no problem bro :)
 
gabafish, so how stronger would you put iv as opposed to other roas? 4x oral?

Yeah, in my experience the BA appears to be about 4 times higher IV compared to oral. Just a rough estimate though. The time of onset is a big factor to take into consideration here aswell. Those of you whom have ever went IV with Ketamine or MXE knows that it hits hard and strong within a few seconds after injection and the same goes for diphenidine. Oral adminstration on the other hand will creep up on you and reach full effects at about T+60-90 minutes. The experiences are fundametally different.
 
Thanks, just wanted the dangerous dose in oral format since that will probably help more people.
 
I'm after the potential long term antidepressant (i.e. ketamine therapy) effects but I'm fascinated by altered states and will explore this one. I have no experience with dissociatives other than DXM so I started very cautiously, a vaped allergy dose a few days ago and today vaped ~5mg, then insufflated 20mg. I took 15mg mirtazapine last night so that could have combined with the effects. About 1 hour after insufflation I got some confusion and a buzzing in my head. I was looking for euphoria, but didn't find any. There was a bit of dysphoria instead. My plan was to gradually ramp up the dosage on the condition that there was no dysphoria or scary effects with that small dose but there was definitely a hint dysphoria there. I'm not experienced with dissociatives, but I am with other psychedelics so I know how a hint of dysphoria can turn into a full blown spiritual ordeal and I try not to avoid that kinda thing unless the time and place is right. Its only been 2 hours since insufflation and the confusion and dysphoria is gone completely. I'm wondering now if adding a benzo will counteract the dysphoria and confusion. Since its christmas I'd like to be able to socialise. With that in mind, I'm guessing I should just leave this stuff alone until after christmas but in reality I'm gonna end up doing it, are there any drugs to take to make things more manageable (as in make it easier to function). Benzos really help with other kinds of psychedelics, but I hear combining them with NMDA antagonists causes blackouts. Thats obviously dose dependant though, if anyone here has experience with combining this with BZ agonists like alprazolam or etizolam can you share your experience.

Also, how does diphenidine compare to DXM? I've had good experiences with DXM doses of 200-400mg (bad experience with doses above and below that) and found that it interacts with trazodone, taken over 24 hours after trazodone theres profound synergy (my theory is that the longer lasting SSRI effects of trazodone are responsible for the synergy), but under 24 hours after there are bad interactions like dizziness, disorientation and nausea. I have never tried it after mirtazapine.

BTW: I should mention that microdosing with this stuff does seem to be providing a significant mood lift. Only done it twice so far though, too early to make any conclusions, might just be the placebo effect.
 
Last edited:
I'm wondering now if adding a benzo will counteract the dysphoria and confusion. Since its christmas I'd like to be able to socialise. With that in mind, I'm guessing I should just leave this stuff alone until after christmas but in reality I'm gonna end up doing it, are there any drugs to take to make things more manageable (as in make it easier to function).
Dude don't be a moron, cmon. Dissociatives, able to socialize? Just don't...
 
Alright, I'll take your advice and halt this experimentation until the time is right. I've heard many people say that low doses of K and MXE are relaxing so I took that to mean that they don't render you unable to function, similar to low doses of serotonergic psychedelics. I take it I have the wrong idea, thanks for filling me in.
 
its quite possible to socialize on low doses, though it depends on the type of socializing i guess and also it wouldn't be a good idea for a begginer for sure
 
I posted this on another forum but I figured I'd post here as well just to add to the collective experience.

So I thought I'd share my experiences with Diphenidine since nobody seems to be talking about it. This is based on four experiences, never higher than 100mg. I'll probably push the dose a little but the magical 150 people talk about seems like a bit much for me. To start this one has almost no euphoria or sense of well-being like many of the arycylohexylamines. WIth MXE you can take a low dose and just relax, enjoying movies and music. With Diphenidine everything seems distant and uninteresting. This is one to take for exploring different states of mind rather than recreation, I'd be very surprised if there was any affinity for SERT or DAT.

The time frame of diphenidine is what makes it difficult, it has a slow come, about an hour without feeling much of anything. Then out of nowhere it all comes on at once. A very powerful dissociation characterized mostly by sensory distortion, a strong buzzing in your head, and amnesia. This state, which I'll talk about a bit more later, lasts maybe an hour tops before devolving into a pretty lucid but still altered headspace. The entire experience resembles a dissociative punch in the face, the rapid onset of the peak leaves you disoriented and confused, combined with the amnesia the second less intense portion is spent mostly wondering what just happened.

Now when I say amnesia I don't mean it in the sense of benzos or alcohol. You can still remember what you were doing and what happened but you can't remember your thoughts, feelings, or even being there really. It feels like you blacked out for about an hour and someone else made up some memories for you to fill in the gaps. It's the kind of drug where I could see myself staring at a wall for 45 minutes without even realizing it. Some people have described this as being similar to a type of "zen state" where you have silenced your inner dialogue but comparisons to becoming a zombie or having a lobotomy also come to mind.

There are no CEVs like MXE or Ketamine but there is the capability for some horrendus sensory distortion. I'm sure all of us are familiar with the "stuttering" effect that can happen with high dissociative doses, the stuttering on diphenidine was to the point where I couldn't tell what was to my left and what was to my right at times. To summarize your senses become a jumbled confused mess and your subconscious seems to take control almost like an emergency autopilot as your conscious mind fails to connect with even your thoughts or emotions.

Next I want to talk about the "buzzing" I've experienced. With many drugs there is an associated physical feeling in your head. Diphenidine is one of those, the only way to describe it is a buzz especially since there is a literal buzzing sound which I can only assume is some kind of tinnitus warped by the sensory distortion. This buzz is very similar to the one that I get on 4-MeO-PCP but beyond this superficial aspect the chemicals are nothing alike. Infact the headspace doesn't resemble arylcyclohexylamines at all, when described they both sound like dissociatives but they *feel* completely different.

Finally I want to mention the combos with MXE I've done. The "boring" phase after the peak tends to last for a really fucking long time and so sometimes I've found myself taking bumps of MXE during it to spice it up a bit. Both times have resulted in a very deep but lucid hole from relatively small amounts of MXE. The hole resembles some of my early MXE holes but without the overwhelming confusion. The visual aspect is more muted than a standard M-hole, there are no otherworldly visions conjuered but there are some rather abstract psychedelic CEVs.

I hate to simply reiterate what everyone else has said before but this is something worth taking a handful of times at most. It certainly gives you some interesting data points in the spectrum of altered states and I would be VERY interested to see it's binding affinities, but it's not one that I can see myself coming back to for mind blowing experiences and certainly not one for recreation.

I will give it one or two more tries, maybe 110mg and once again mixed with noopept. The second phase is a good launching point for other dissociatives but I also found the mix quite physically draining.

This is quite close to my experiences with this: I Really liked this stuff - certainly didn't seem dysphoric - I can see why some would say neutral maybe: I've had quite valuable experiences off it. It's definately distinct stuff. Orally takes a good hour to kick in and the trip lasts about 2 hr although true baselines a bit further off although I wasn't bored, I'd cetainly like to do more and explore it a bit deeper. There's definately some buzzing which superficially reminds me of ibogaine and makes me feel I'm heading somewhere magic. It doesn't seem to have the amnesia of ket (better recall)nor be as disabling .As to DXM - only tried that twice & I found this better.
 
Last edited:
I'm after the potential long term antidepressant (i.e. ketamine therapy) effects

Chances are there are no long term antidepressant effects. A lot of NMDA antagonists are great for rapid relief of depression, but there have never been any studies for maintenance of those antidepressant effects and judging by my own extensive dissociative use and what I have seen from others, you might get even more depressed. Careful man.

its quite possible to socialize on low doses, though it depends on the type of socializing i guess and also it wouldn't be a good idea for a begginer for sure
I would recommend just drinking if you need a social lubricant for the xmas celebrations. ;) Then again, there's probably people out there who can take their math exams on 100mg PCP.

Alright, I'll take your advice and halt this experimentation until the time is right. I've heard many people say that low doses of K and MXE are relaxing so I took that to mean that they don't render you unable to function, similar to low doses of serotonergic psychedelics. I take it I have the wrong idea, thanks for filling me in.
Hope you had a nice xmas still. I actually just received my diphenidine yesterday and was very eager to try it. Had to hold myself back until I'm alone tomorrow. :D
 
Last edited:
I gave it a whirl last night, wrote my trip report here:
http://www.shroomery.org/forums/showflat.php/Number/19322583
I'll tell ya, its a strange one alright. Stranger than MXE. Someone above asked about etizolam, I can confirm this is a good combo. I hid all substances in a hard to get at place but I had no desire to redose. I don't think I was physically capable of it, I had this important task that I needed to do before 3:33. I don't really know what that task was, I was trying to figure something out or solve some kind of universal mystery or something. I think I solved it, I believed I had uncovered the meaning of the everything and it all revolved around the hole and the number 0. I snorted 80mg over about an hour period.
 
I gave it a whirl last night, wrote my trip report here:
http://www.shroomery.org/forums/showflat.php/Number/19322583
I'll tell ya, its a strange one alright. Stranger than MXE. Someone above asked about etizolam, I can confirm this is a good combo. I hid all substances in a hard to get at place but I had no desire to redose. I don't think I was physically capable of it, I had this important task that I needed to do before 3:33. I don't really know what that task was, I was trying to figure something out or solve some kind of universal mystery or something. I think I solved it, I believed I had uncovered the meaning of the everything and it all revolved around the hole and the number 0. I snorted 80mg over about an hour period.
Lol dude, you had me when you said "This is substance is even weirder than PCP". Not that I wasn't gonna go for 150mg tomorrow anyway, but now I'm really fucking optimistic about this substance. The harder the mindfuck the better, when it comes to dissociatives.
I just had 100mg orally to test the waters, since I'm pretty drunk and would probably just puke my guts out and not remember a thing on a full blown dose. Really looking forward to tomorrow morning. Gonna cut off my internet, hide my cell phone battery, turn off the lights and then... who the fuck knows? probably just complete and utter boredom!
Ketamine, PCP and MXE have just stopped being weird for me, despite me having been off them for years aside from single doses every few months. If I go and give myself a good and proper iv dose I just won't remember shit.
Really hoping for diphenidine to allow me passage to The Twilight Zone once more.

edit: nothing noteworthy going on at t+70min @100mg oral. this is over 7h post xmas dinner, 3h after which 150-200ml 114proof whiskey were consumed over the course of 4h(occasional drinker, 90ml ethanol, less than 2l beer -> buzz with slight disinhibition). maybe some euphoria, but that could just be due to being very excited about this novel chemical. there should be SOMEthing right? if this doesnt turn into anything, ill go straight for 180 oral 2moro morning. (no disso use for months except for 80mg iv+30mg rectal mxe about 5 days ago, 90kg bodyweight, male, 9yrs of episodic->sporadic k/pcp/dxm/mxe experience, in that order)

edit2: so... any more anecdotes about iv experiments? any info appreciated, even external links to 1st hand iv reports.

edit3: at t+80min there might have been something akin to a dissociative come-up/down that never really takes off. a fleeting hint of background white noise and metallic body feeling. could just be the joint i lit at t+60. this surely is nothing to write home about (good enough for a bluelight post though ;P).

edit4: trying to justify that comment about the current uneventfulness being sufficient input for a bluelight post, i google things like jigsaw pieces puzzle (e.g. "puzzle pieces saying"). what im trying to say, when u want to get an idea of what a novel psychoactive chemical has to offer, sometimes the most superfluous post somehow adds to the big picture. so while i dont have anything clever or profound to say (despite there being a strng urge to do so, obviously), its still noteworthy that i find a sense of cleverness in feeling particularly unclever and dull right now. it might be the joint (daily nighttime smoker), it might be the whiskey i had earlier being manufactured on a very small island, it might be the diphenidine playing tricks on my brain at 100mg oral. maybe the barrels used on that island where the whiskey was manufactured are host to an endemic fungus that does something to the booze, something that modulates those effects of the whiskey targeted at our nmdar's. i really cant tell right now, but im still hoping for a massive fucking transient psychotic state tomorrow.

edit5 (im really still in edit4, but paragraphs are great to improve readability of a post!): there have been days in my life where i have perceived myself as a lot smarter than i do now. most days of my life went down like that. i really want to be clever and have profound realizations though right now. booze does that right? i didnt have that much to drink.

edit6 (you guessed it, its still edit4, but a new train of thought) tomorrow i will look down on my naive 1 day younger self. i am very glad im not posting on facebook right now.

edit7: maybe if i iv this, i get an idea of what a stroke feels like.

edit8: t+190min ive been pondering whether it would be a good idea to become a clown or not for what seems like more than half an hour. very promising compound, this one. i can really see some serious enlightenment coming my way, so deep.

edit9: ok wtf, if i can compare this to any other dissociative, id say it feels very close to pcp. i used to get very hard erections every time id come out of a pcp haze and this stuff seems even more seckseh. i wanked like 3 or 4 times and each time was more awesome than the last. the mindset is also very far on the weird end, e.g. ive been wondering if i might have a brain tumor lol. this is exactly that sort of bizarre alternate reality shit that i loved about pcp. becoming a CLOWN?! WTF?! ill give it another try tomorrow for sure and will go for a higher dose. this seems like very very awesome and powerful stuff so far!!! i should mention that i really never enjoyed mxe and dxm the way i enjoyed pcp and k.
 
Last edited:
Ended up going to bed at T+4:30, have slept 6h and ingested 150mg T+9:30. Very much looking forward to this trial.
 
Top