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The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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You can do a structure / substructure search in the NIST WebBook. Draw it out, hit "Done", and make sure to do a substructure search. The interface is rather clunky, but it works. I drew out the top left one and got heroin. Too lazy to do the others.
 
We all start somewhere! It's okay to be initially ignorant (everyone who learns anything is by definition so). It's also fine to be open about personal uncertainty as you learn. :) I am, at least. . .

ebola
 
What's the difference between a structural and positional isomer? any one :)

To me it seems to be the same thing....
 
Positional isomers are a subset of structural isomers. A structural isomer is just a chemical that has the same empirical formula (C6H10N or whatever), so it can really refer to two very different chemicals (there's an endogenous hormone that's a structural isomer of THC, for example). Structural isomers have the same number of each type of atom, but can have those atoms arranged in any structure, and might look nothing like each other. A positional isomer is a special case where the hydrocarbon skeleton is the same, but functional groups are at different positions (like 5-OH-DMT and 4-OH-DMT, for example). So, all positional isomers are also structural isomers, but the former is a much narrower group. We might reasonably expect positional isomers of drugs to also be functional analogues, whereas knowing that two chemicals are structural isomer is pretty useless to us, given that they aren't necessarily structural analogues.
 
So, say one were to be working with a pure fentanyl salt, would dosing buprenorphine beforehand be a sensible and effective precaution? Would this sufficiently preclude any fentanyl that were accidentally ingested from binding?
 
No, fentanyl has a higher affinity than buprenorphine. hence why docs can use it in surgery for people on suboxone.

The best option is to not fuck around with drugs that can put you 6 feet under.
 
It is my understanding that MDMA releases 5-HT, DA, oxytocin, and prolactin. I know MDA releases 5-HT and DA too at the right dose, but does MDA also release oxytocin and prolactin?
 
Increased oxytocinergic activity is a downstream effect, likely stemming from 5ht1a activation via serotonergic release. However, the entire pathway hasn't been traced out in detail. The effect on prolactin is even more poorly understood. This study suggests that vesicular 5ht is involved but SERT reversal is not (Nash et al. 1988) (wow, cutting edge, this ain't ;)).

ebola
 
The pharmacology of MDA and MDMA should share a lot of ground. I think they are pretty similar, with MDA having more activity at postsynaptic serotonin receptors (c.f. more hallucinogenic).

There's no reason to expect MDA wouldn't release oxytocin.
 
This is a silly question, but when I cut a piece of paper or a plastic jug with scissors, am I splitting covalent bonds? If so, what happens to the severed polymer tips?
 
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