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the drug that fucks you up the most is...

Alcohol fucked me up better mentally and physically than any other drug I tried in my life. I almost don't drink anymore, and when I do it's 2, sometimes 3 drinks max. Headaches, nausea, digestive problems, bad sleep, poor judgement, emotional instability, aggressiveness, etc. are too high a price to pay for that rather cheap intoxication.

A close second would be benzos, especially alprazolam: if you don't know your exact limit with that stuff, you do and say crazy shit you don't even remember the next day. Used therapeutically for a SHORT period of time, it is safer than alcohol; but messing with alprazolam (or any strong benzo) recreationally is even more dangerous than alcohol imo.

Opiates did fuck me up and cause serious problems - but they never made me lose my mind.
 
Haven't done many but ofc it's Alcohol. Got really fucked up once and could have gotten robbed and not remembered shit and since then I haven't really even been able to drink more than 1-2 cans.
 
oral thc.. yeah out of all my rocket ships this one takes the cake.. and that is out of allot of ships;)

Edit: by how fucked up I mean how fucked up I got.. not how fucked up I acted or how fucked up my life became.. I was on the nod for three days off one brownie.. eight pans made from qp of headstash cough + very large amount of only kind jack and SD, bud trim only, cured cuttings, 3 oz of bubble berry kief, and four ounces of NL5.. yeah all done=D
 
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Heroin. Took too much while I was in town one night, had to walk it off, and was afraid the whole time that I was walking funny, and would be stopped by campus police(it was a college town). Thankfully, I ran into a friend and we shot the shit for an hour or so, and by that time, I was good to head back home.
 
A lot of people say benzodiazepines here which I don't doubt, I suppose I just have never taken them in such large doses to actually pass out or do crazy shit, and I used to have a habit of 18mg xanax on top of IV 1.5g heroin per day, so I don't know what to say...................

Anyways, my responses would be:

GABA-a agonists like ethanol (alcohol)
NMDA antagonists like ketamine, DXM, PCP, MXE, etc....
5HT2-a agonists like LSD and other strong psychedelics

and mostly in that order. I would have said alcohol all the way until I did large doses of ketamine, but even still, alcohol alcohol alcohol, fuckkk

Edit: like the poster above me, the first time I injected heroin, it realllyyyyy fucked me up, first few times actually, could barely function, had to just chill and watch TV or listen to
music basically.
 
Fuck up in a good way? or bad way? lol

For fucked up in a good way....

Any psychedelic amphetamine (MDMA, MDA, All that good stuff) gets me really fucked up. But's it's always ALOT of fun and I never regret it the next day.

For fucked up in a bad way...

Dextromethorphan. I know it's OTC - but nothing else I've ever taken has made me feel as shitty as DXM has. For some reason I keep doing it though......
 
Agree with SwampFox - there's good fucked up and bad fucked up.

Good = psychedelics/MDMA, had some incredible times with either or both of them.

Bad - like so many others have said, alcohol. Usually leads to a major case of "fuck it, don't care" with rotten consequences - ruined friendships and a reputation for saying stupid things which are usually true but just shouldn't be said.
 
Whosajiggawaaa said:
Alchohol and cocaine - get so fucked i reply to messages with completely indecipherable answers, but it's been years since i've indulged in that...
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odd, IME cocaethylene is actually a more "sober" feeling drug than alcohol on it's own, with more euphoria and less drunkenness.
 
dilerients! hands down.
followed by long-term stim binges.
basically anything that caused hallucinations AND delusions
 
Destruction? Depravity? Madness? Loss of Everything? MD Mutherfuckin' PV! FTW! FT 'total' Loss!

All the way, ride it to the bottom, burning and screaming, ranting at the things that aren't there... Just my 2 cents...

^Oh, 5-ht101 covered it, yeah that, in a spermy smoky scent!
 
bigfanofthem said:
odd, IME cocaethylene is actually a more "sober" feeling drug than alcohol on it's own, with more euphoria and less drunkenness.
Click to expand...

Its (cocoaethylene) also a lot more cardio-toxic than coke alone so consumption of coke and liquor together should be limited and taken reasonably easy when on it. Ie - physical exertion and other drugs, kinda thing etc.

Currently for fun factor i am enjoying a cocktail that includes IV morphine, oral valium, oxycodone and weed. Maybe just one or two select premium beers from micro-breweries to really enjoy the taste along with a fine and freshly rolled cigarette or big fat fine cigar. God damn float off to heaven.

The same drugs are responsible for fucking fucking up my life as well. Throw methamphetamine to that list too.
 
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