• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Is there a "ceiling" to addiction?/the extreme of w/d

RedRum OG

Bluelighter
Joined
Jul 18, 2009
Messages
3,693
Location
MN
Ever since I fully understood opiate addiction and especially after being involved myself, I've always wondered, is there a point that your natural opioids completely stop being produced by the body? Or could you theoretically keep raising your tolerance/habit infinitely? It's a scary thought, someone shooting increasing amounts of heroin for 40+ years could go through some mind bending kicks. Or is there a point where it can't get any worse?

Also we all know the usual opioid withdrawal symptoms, but if someone were on incredible doses of strong opioids like methadone, heroin, oxymorphone, fentanyl etc, could it go further? When I was in detox/rehab the nurses told me about some guy who used up to a thousand mg of methadone a day, and suffered seizures and delirium in detox. I had a hard time believing this, but they insisted opioids were the only drug he used/abused and had no apparent physical cause for the seizures, and no history of having them before.

Answers appreciated, hope my question makes sense. Also stories/experience with the severe end of addiction (we're talking beyond shooting multiple bundles or grams of fire dope etc)
 
This question could be formulated to whether receptor downregulation could go on forever, and clearly it cannot because there would be no receptors left and I doubt if cells would even work at that point. However this limit is so far away no human could go there, perhaps in animals it could be tested. Maybe there are other complications such as liver failure before the ground zero.
 
The longer you have been on an opioid the worse the withdrawals are, and the dose and specific drug of course play a role. It is also likely the more times someone has experienced withdrawal the worse it gets. During around 16 years of opioid use I have found withdrawals to consistently get progressively worse.

People have died from opioid withdrawal. Everyone likes to say it's never fatal but it actually can be, especially methadone. There have been documented cases of this happening, for example people who were in prison and were denied their methadone and died. Methadone withdrawal can definitely cause seizures. Methadone withdrawal is the worst, primarily because it takes such an incredibly long time. The human body may normally be able handle the stress of opioid withdrawal if the worst only lasts for a week, but when it lasts for months it just becomes too much. Some people die from dehydration; some people have seizures and die; precise cause of death can be unclear but there are definitely numerous deaths directly attributed by the coroner to methadone withdrawal.

I don't think one could really raise one's habit infinitely, in my experience opioids eventually stop doing much other than keep you out of withdrawals (and causing side effects/adverse health effects), and barring vast amounts of money or a doctor who is willing to prescribe you ridiculous quantities, it becomes difficult to really use significantly more in order to find out if you could still get additional effects. Also I am recently coming to the conclusion that with most opioids there gets a point where you would probably die from too high a dose, regardless of your tolerance. This dose may be very high, since there are certainly people with insanely high opioid habits, but I don't think you could realistically just take endlessly escalating doses of opioids even if all constraints like lack of money/availability were theoretically removed.

As for whether it is possible for the body to completely stop producing endorphins, it certainly feels like that to me. I will have to see if I recover (I quit methadone a couple months ago after 10 years, after a very slow and painful taper) and I can only try to keep up hope that I can, otherwise I think I would lose the will to live.
 
Someone I knew had been on methadone for 20 years and quit, he said after one year when he still felt like ahit he went back to it because life just wasnt worth living that way. It seems methadone can fuck up your endorphin activity for good, I hope this is not the case with you swimmingdancer.
 
Me too, Swimmingdancer. I seriously hope that this is not the case for you. Does exercise help? Sorry OP for off topic question.
 
Most people get tired of it eventually, those who don't typically top out around 300-500mg pure heroin/day (in europe, switzerland i think), according to a documentary i saw.
 
sounds possible. methadone detox was much closer to benzo withdrawl than opiates for me, at least the "paws" were because I got the physical symptoms out of the way with a taper. It made my mind go crazier than an other opiate, pupils the size of dimes, random bits of sobbing for no apparent reason.
 
Someone I knew had been on methadone for 20 years and quit, he said after one year when he still felt like ahit he went back to it because life just wasnt worth living that way. It seems methadone can fuck up your endorphin activity for good, I hope this is not the case with you swimmingdancer.
That sounds kind of common. I think if it were me on done everyday for several years plus I would go on an antidepressant after about the first month off methadone knowing PAWS could probably go on up to two years.
I do think the brain does eventually "normalize" itself given enough time.
 
Thanks for the replies

Wow okay I always knew methadone w/d's were overall described as the worst opioid, but never knew the extent.

I can't believe of all the opioids for maintenance they choose methadone. That's like how they originally used heroin as "cure" for morphine addiction.

Good luck to all you folks on long term methadone. I was shooting dope for almost 2 years and prescribed oxy for a few more. Have been on bupe for a year now, and am tapering, and I'm glad I chose that over methadone after reading so many horror stories
 
Someone I knew had been on methadone for 20 years and quit, he said after one year when he still felt like ahit he went back to it because life just wasnt worth living that way. It seems methadone can fuck up your endorphin activity for good, I hope this is not the case with you swimmingdancer.

Yeah, me too! That is my biggest fear. I could deal if I knew I would feel healthy and happy in a couple months or something, but hearing about people who said they still felt awful a year or more later is really scary. The not knowing is really hard. I remember some study (wish I could find it) where people experiencing pain were either told that they would feel better in a week or would have the pain for the rest of their life (when that wasn't really the case), and the subjective and objective markers of pain were much higher when people were told the pain would not improve. Makes total sense to me.

Me too, Swimmingdancer. I seriously hope that this is not the case for you. Does exercise help? Sorry OP for off topic question.
I don't feel the "high" that normal healthy people feel from exercise, and it's extremely hard to motivate myself to do any, because I am so weak, fatigued and in so much pain, and because I don't notice any immediate benefits/rewards from exercise, but I'm sure it's definitely a good idea and would be helpful in the long run. It does seem to help with the restless legs a bit. I am really trying to gradually get more exercise, as I feel it's important; gentle things like yoga and short easy walks seem to be the best right now.

sounds possible. methadone detox was much closer to benzo withdrawl than opiates for me, at least the "paws" were because I got the physical symptoms out of the way with a taper. It made my mind go crazier than an other opiate, pupils the size of dimes, random bits of sobbing for no apparent reason.
I wish that my taper had alleviated the physical withdrawals. In retrospect if I had to do it again I would taper much faster than I did. It goes against conventional wisdom but I think that tapering so slowly and gradually actually did me a dis-service and just substantially prolonged things while only make WDs slightly less intense.

That sounds kind of common. I think if it were me on done everyday for several years plus I would go on an antidepressant after about the first month off methadone knowing PAWS could probably go on up to two years.
I do think the brain does eventually "normalize" itself given enough time.
I don't think taking an antidepressant for one month would do anything - most antidepressants take over a month to see any effects. And a lot of them simply don't even work for most people (the ones I've tried certainly didn't help for me), plus they are dependence-causing and can leave people with lasting depression etc after they stop them. I don't really want to just end up with another drug dependence. I am taking some meds to try to help with PAWS though, not sure how well they are helping though.

Thanks for the replies

Wow okay I always knew methadone w/d's were overall described as the worst opioid, but never knew the extent.

I can't believe of all the opioids for maintenance they choose methadone. That's like how they originally used heroin as "cure" for morphine addiction.

Good luck to all you folks on long term methadone. I was shooting dope for almost 2 years and prescribed oxy for a few more. Have been on bupe for a year now, and am tapering, and I'm glad I chose that over methadone after reading so many horror stories

I know, it really makes me angry that methadone is so easily given to people trying to get off opioids. Not only is it more dependence-causing, it can be worse for your mental and physical health. When I first started methadone my doctor at the time said that it had no adverse health effects, and there was no hurry to get off it because you can stop whenever you want by tapering over a few weeks time and would get no withdrawal symptoms at all that way! I really think people deserve to know what they are getting themselves into.

I also believe that the pharmaceutical companies and methadone clinics are perfectly happy that methadone is so dependence-causing because it often means a guaranteed customer for life. Many methadone doctors believe that opiate addiction is a incurable disease that requires the person to be on medication for the rest of their life. I actually had one doctor say to me that anyone who has been addicted to opiates should take methadone forever, saying "You wouldn't expect a diabetic to stop taking their insulin would you?" and that "the risk of relapse is too great for people who quit methadone so it's much better to be on it forever than take the risk that you might turn back to other opioids if you quit methadone".

Then there is the "moral" issue (especially in North America), methadone is considered "better" than other opioids because once someone has stabilized on it for a few weeks they usually feel no euphoria and simply the alleviation of withdrawals, plus a high enough dose will substantially block other opioids, and it's hard to abuse methadone, so the anti-drug view feels all this is a good thing because maintaining someone on an opioid that they felt good from would somehow be immoral :X. We get treated like criminals and our freedom and privacy hugely limited, the term "liquid handcuffs" exists for a very good reason.

Anyway, sorry for taking over your thread :)
 
You wanna know beyond multiple bundles and grams a day?! That's really not that common....I've been over 5 bundles a day and at around 3 grams a day for several years....It does kind of reach a point where getting high becomes very difficult and the WD is very severe, barely able to move, locked up and sweating, shaking vomiting....

I have to say the worst WDs I ever had were going into detox coming off heroin, as far as symptoms go, but like a lot of people have been saying, methadone can definitely be the worst under certain circumstances! From what I've seen, acute heroin withdrawal doesn't seem to go beyond 2 weeks max, no matter how much you're doing....

I think the worst would be stopping high-dose methadone, cold turkey, with no taper! The worst WD stories I've heard have usually involved a scenario like that.....

I did have a dealer that was shooting 7+ grams of dope a day and swore he couldn't feel anything at all no matter how much he did! He'd just scoop some dope out of his head bag, not even paying attention to the amount and shoot it!! That's the worst I've seen....

There must be cases of people using ounces of day of heroin, and I imagine it sucks!
 
Then there is the "moral" issue (especially in North America), methadone is considered "better" than other opioids because once someone has stabilized on it for a few weeks they usually feel no euphoria and simply the alleviation of withdrawals, plus a high enough dose will substantially block other opioids, and it's hard to abuse methadone, so the anti-drug view feels all this is a good thing because maintaining someone on an opioid that they felt good from would somehow be immoral :X. We get treated like criminals and our freedom and privacy hugely limited, the term "liquid handcuffs" exists for a very good reason.

I guess it all comes down do cost. Methadone is cheap as shit. I don't think its a coincidence that Switzerland is one of the richest countries in the west and one the few that offers heroin maintenance. I bet it is a lot easier process to come off than methadone.

http://www.vice.com/read/hamiltons-pharmacopeia-804-v16n4

read the bit about the guy withdrawing from Pharao-fentanyl and the other one who killed himself (although I guess some people do this on heroin cold turkey as well)

Umm, equal to 3000 bags of dope/day, thats ridicilous. It seems that fentanyl analogues are really the way to go for tolerance boosting.
 
I wish that my taper had alleviated the physical withdrawals. In retrospect if I had to do it again I would taper much faster than I did. It goes against conventional wisdom but I think that tapering so slowly and gradually actually did me a dis-service and just substantially prolonged things while only make WDs slightly less intense.

I also believe that the pharmaceutical companies and methadone clinics are perfectly happy that methadone is so dependence-causing because it often means a guaranteed customer for life. Many methadone doctors believe that opiate addiction is a incurable disease that requires the person to be on medication for the rest of their life. I actually had one doctor say to me that anyone who has been addicted to opiates should take methadone forever, saying "You wouldn't expect a diabetic to stop taking their insulin would you?" and that "the risk of relapse is too great for people who quit methadone so it's much better to be on it forever than take the risk that you might turn back to other opioids if you quit methadone".

Then there is the "moral" issue (especially in North America), methadone is considered "better" than other opioids because once someone has stabilized on it for a few weeks they usually feel no euphoria and simply the alleviation of withdrawals, plus a high enough dose will substantially block other opioids, and it's hard to abuse methadone, so the anti-drug view feels all this is a good thing because maintaining someone on an opioid that they felt good from would somehow be immoral :X. We get treated like criminals and our freedom and privacy hugely limited, the term "liquid handcuffs" exists for a very good reason.

Anyway, sorry for taking over your thread :)

Yeah doctors are the worst liars. After I started shooting heroin got a doctor who in the end was scripting me 200mg oxy per day, when I went in for the original appointment he stated "it's something like 3% of patients who become addicted to these pills, despite what the media says".... I'd like to see anyone be on an opiate every day for more than a few weeks not become addicted... Almost laughed in his face but didn't want to break the illusion that this was legit;)

I really wish all the misinformation about Suboxone would disappear. "You can't shoot it cuz that gets the naloxone in your system and will make you sick"... Every time I hear that I want to cry because I don't even know what part to correct first. Also, bupe is IME, the god of detox/maintenance opioids cuz it is 1) long half life 2) contains naloxone so stops from being abused with "real" opiates in system. But mostly 3) because if you're on a dose above 1mg, no matter what, it won't get you high, even doubling or tripling dose, unlike methadone. I love this aspect as even when I've been dumb and wolfed down multiple days doses, it feels the same as normal dose. And 4) very low ceiling so tolerance has very low limit

And yea methadone docs are even worse I hear, they know if they can convince you to be on for a few years chances are you'll be bringing them money for the rest of your life. It's horrible but hey what area governed by laws isn't completely backwards and immoral?

Np any reply is a good reply! I appreciate all discussion
 
I guess it all comes down do cost. Methadone is cheap as shit. I don't think its a coincidence that Switzerland is one of the richest countries in the west and one the few that offers heroin maintenance. I bet it is a lot easier process to come off than methadone.



Umm, equal to 3000 bags of dope/day, thats ridicilous. It seems that fentanyl analogues are really the way to go for tolerance boosting.

Yes this effect is called tachyphylaxis and typical of fentanyl and it's derivatives . In Estonia where there is a Fentanyl epidemic users complain how they can't get back to smack and have to shoot up 3x as often.

But mostly 3) because if you're on a dose above 1mg, no matter what, it won't get you high, even doubling or tripling dose, unlike methadone. I love this aspect as even when I've been dumb and wolfed down multiple days doses, it feels the same as normal dose. And 4) very low ceiling so tolerance has very low limit

P.S redrum as any french subuTEX ABuser will tell you , the ceiling effect only kicks in at about 16 mg IV which is coincidentally exactly what a 1 ml syringe will hold (tiny generic tablets).

The medically advertised ceiling dose is 32 mg (probably sub-lingual) look it up.
 
Top