Opioids Respiratory depression and beta-adrenergic agonists

[jambabomba]

Lets think a situation where you have took too much of some depressant and mainly opioid. You don't have acces to naloxone and start to feel your respiration isn't working good enough. I've been in belief that beta-adrenergic mimics or stimulants would counteract at least with some efficacy against respiratory depression effects.

Is there any use of ex. ephedrine or clenbuterol with possible overdoses with opioids?

I have example of my own..

I have usually carried some stimulant with me, mainly ephedrine and clenbuterol for cases I took too much depressants and have to still be functional. Some time ago when my withdrawal process ceased for a while I took eventually very big doses of drugs over two weeks period increasing amounts up to about 30g phenibut, 3mg clonazepam, 1200mg Lyrica and 500mg tramadol a day. So my last day in that period I had took so much tramadol and other cns depressants that I felt my respiratory was going shallow and lame so I fealt my respiratory function was somewhat depressed. Then I took 400mg caffeine, 60mg ephedrine, 20mg dexedrine. Later I took clenbuterol 40ug and was breathing quite rapidly. [I have to mention that mixing clenbuterol with other beta-adrenergic drugs isn't very safe combination regarding your blood pressure and heart but in my case there was very much counteracting drugs for that effect. Anyway, I have blood pressure monitor and I'm able to measure my pressures and also have clonidine, enalapril and propranolol to take if my blood pressure goes over 200 and have experience with everyone of those drugs. But just to those of you who don't have: be careful to mix sympathomimetics].

So what do you think about beta-adrenergic mimics/stimulants in a case of respiratory depression? Would it be reasonable to take them if you have overdosed with strong opioid and don't have acces to naloxone? Would there be negative interactions with opioids?

 

[Znegative]

Well, I know for a fact that stimulants can work for resperitory depression, but Im not so sure how safe that would be. Beta-Adrenergic-Agonists are definately not good to use in excess, My father's friend and coworker actually died from a heart attack after repeatedly using formoterol for her asthma. Also there are beta-1-Adrenergic agonists, and Beta-2, B-2 being responsible for relaxing the smooth muscles of the lungs (which is why they are used for asthma), B-1 used for cardiac stimulation (used for heart failure).

 

[jambabomba]

Well, I know for a fact that stimulants can work for resperitory depression, but Im not so sure how safe that would be. Beta-Adrenergic-Agonists are definately not good to use in excess, My father's friend and coworker actually died from a heart attack after repeatedly using formoterol for her asthma. Also there are beta-1-Adrenergic agonists, and Beta-2, B-2 being responsible for relaxing the smooth muscles of the lungs (which is why they are used for asthma), B-1 used for cardiac stimulation (used for heart failure).

Little of topic..

Okey. Yes I know they aren't very good for blood vessels and heart. They supposedly have hypertrofic effect on cardiac cells wich might increase the risk of heart failure in the future? Personally (based what I've read about subject) I believe that could be very much negated by eating q10 ~200mg/d, d-ribose and L-carnitine + antioxidants. Basically heart hypertofy starts when heart has to work too hard (because of narrowed blood vessels, rised blood pressure or stimulants etc.) and cannot generate enough energy for it. It starts to dilate to compensate that energy deficit and work demand. By giving enough substrates to energy production for heart when it is working hard you could possibly prevent any kind of damage to it.

Do you have any idea why formoterol is used for ashtma but not clenbuterol? I have used clenbuterol and it positively affects my depression. I even used it during benzo withdrawal because of its positive mental effects combined with fasting/ketosis. It of course exacerbated some symptoms of benzo withdrawal but eased some at least in my experience.

What do you consider excess? My beta-adrenergic receptors are probaply very much downgraded because of benzo withdrawal. Thats because even 40ug of clenbuterol doesn't now significantly affect my blood pressure or heart rate. BPM is about 70 and blood pressure 140/80 with 40ug clenbuterol now.