Has anybody tried cerebrolysin?
Looks interesting. Pricy though.
Nootropics I have tried include:
Galantamine, huperzine-A (both anticholinesterases, careful with these, an OD can be dangerous, remember, nerve agents are also anticholinesterases)
Piracetam, aniracetam, pramiracetam, all with choline bitartrate)
Sulbutiamine (was decent, nothing massively impressive, but still decent)
Piribedil, a D2/D3 type dopamine receptor agonist, also an alpha2 adrenoreceptor antagonist (but I don't think it can be that potent of an A2 antagonist, as nearly ANY A2 antagonism causes severe akathisia in me....lol, actually I need the opposite, large doses of clonidine and/or tizanidine, as I'm autie, and alpha2 adrenoreceptor agonists are an absolute fucking godsend for suppressing overloads)
I quite liked it, improved my motivation and executive function significantly; although I didn't notice much of an improvement if any on memory itself). And betahistine, a H3 histamine receptor agonist, which was quite good at improving memory. Doesn't compare to galantamine or pramiracetam though)
I am looking forward to trying DM-235, I have had that on the back burner so to speak in the lab for aaages, just never gotten around to actually synthing it)
Its an AMPAkine, and one of the most potent known by weight IIRC, not sure if its ever been tried in a human before. Looks good in the rats though (no, I didn't run the tests myself. I am massively against animal cruelty, it is right up there with paedophillia, rape, and stamping on babies' heads for fun in my book in terms of being absofuckinglutely abhorrent. My lab does NOT use animals, in any way. It makes me truly sick to my stomach, reading journal articles, and hearing of the torments inflicted on animals under the aegis of science. No different, and in many cases, even worse, than the atrocities perpetrated upon the yids by Dr.Mengele in the nazi era)
Active in the microgram range. Easy synthesis too. I have the stuff necessary to run the synth, propionyl chloride, HCl, benzoyl chloride, and of course, piperazine. I just need to purify my piperazine, and I am often struggling with impaired executive function. The AMPAkines look kick arse in general, but sunifiram/DM-235 looks like one of the best of the bunch.
Huperzine-A, a cholinesterase inhibitor derived from a species of club-moss is pretty inexpensive, although it doesn't compare to galantamine in my experience with both (galantamine is also an agonist at the alpha7 type of nicotinic acetylcholine receptor, giving it an additional mode of nootropic action in vivo. Its fucking expensive though, I'd love to be on it full time, but I just can't afford it, I am only on disability benefits...lol, I actually get PAID for being autistic, which is fucking sweet
)
Huperzine-A is, however, an NMDA antagonist. NMDA antagonists are known to impair cognition and memory formation/retention. Anybody think this is likely to lessen the effectiveness of the drug?
I bet it would synergise pretty well with aniracetam or pramiracetam in particular, as both are known to have some degree of AMPAr PAM activity, which of course, leads to increased NMDAr mediated neurotransmission. Anybody tried the combination?
I'd LOVE to try phenylpiracetam, but I have thus far not been able to find a source
It sounds like the creme de la creme of the 'racetam nootropics, even better than pramiracetam perhaps. Also appears to be somewhat of a stimulant.
I have a question also, regarding piracetam. I read that it has been used to treat myoclonus. I have a problem there, namely myoclonus, sometimes developing into full-blown myoclonic seizures, anybody tried using piracetam to treat myoclonus? Also, are the other 'racetams also effective against myoclonus? I'm fed up with living with it. It has led to some rather nasty accidents, such as my arm twitching, and driving my wrist down the length of a powerful circular saw blade, or another time, accidentally tossing acid on myself.
And does levetiracetam (keppra), an anticonvulsant, possess any nootropic properties? If so, I'd be interested in giving it a try to deal with my seizures and myoclonus. I currently just take chlormethiazole for the myoclonus and as an anticonvulsant, it does a great job, but it doesn't completely eradicate either my myoclonic jerks, muscle fasciculations or seizures. Certainly reduces them, but doesn't completely kill them off. I'm wondering if keppra might be a decent choice of anticonvulsant. Would be neat if it could kill two birds with one stone, both preventing seizures/myoclonic jerking, and acting as a nootropic in its own right.
