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Baclofen overdose, issues, and other scientific questions. Help is much appreciated

S

sirbishop

Bluelighter
Joined
Apr 25, 2008
Messages
46
Hi Everyone. I will try to keep this as condensed as possible but I have some questions and experiences to share regarding baclofen.

A little about me:
Diagnosed OCD/Major Depressive.
If my OCD is not managed I will pick up a benzo and coke habit.
Nothing has helped my OCD as much as memantine (40mg/day at the moment) and baclofen.

This past weekend I overdosed on baclofen. I was going by it's short half-life, but I believe there is possibly a D/NE rebound effect causing hypertension and tachycardia. So in short, in a days time I consumed ~250mg baclofen. These were the good/bad symptoms:

Good:
-Empathy
-Euphoria
-Music sounded EXCELLENT, almost too good
-Pro-social effects
-Appetite suppressed
-Extremely optimistic mood
-OCD was nearly eliminated
-Control over my ejaculate and high libido
-Intense focus and interest

Bad:
-An extremely intense "whoo whoo whoo whoo" sound in my head, that was only somewhat comforted by music/earplugs.
-Weak/fast heart rate
-hyper-excitability (couldn't sit still for shit, must have walked in and out of the kitchen 30 times in 45 minutes) and accomplished nothing
-Vision issue: If I looked at say my ipod screen then looked up, at random I'd get a "flash" of the ipod image in my vision regardless of what I was looking at. When this happened a "ckkkkk" sound would occur, as if there was a fault in my brains processing of information.
-Labored breathing (woke up with drool on my pillow, which I rarely do)
-Very vivid dreams that I clearly remember
-Water retention in my chest

Has anyone else experienced anything of this nature?
I would love to find a dose that I could minimize the bad effects and still experience some of the good (just not to such a high extreme).

Never in my life has a drug made me feel so good. Its as if I was cured of my OCD (which has caused me a shit load of trouble since age 8, I'm 29 now).

Today I took 50mg and when I was at the gym, I noticed my heart rate was weak and fast and I was somewhat lightheaded. I haven't experienced this before.

I was reading that Baclofen can inhibit one of the CA+2 or NA+2 channels (can't recall exactly), messing up K levels. Which leads me to believe the reason

Sorry for the lengthy post, I suppose I'd like to ask:

Has anyone had similar experiences?
Do you believe there is a D/NE rebound?

I searched for drug interactions with memantine and baclofen and found nothing.

Can you see of a way there would be an interaction or potentiation?
Reply With Quote

I also began to get a feeling of psychosis. I fell asleep and woke up and didn't know what day it was. It was 8pm and I thought it was 8am. I was wondering why the sun wasn't out.
 
This is not really a basic question so I'm going to move it from Basic Drug Discussion to Other Drugs, which is for more intermediate questions (of drugs that don't have their own focus forums).


I had no idea baclofen was even used for OCD. I'm inclined to agree with you that this might be a rebound effect. As I understand it, baclofen, by it's action on GABA receptors, decreases dopamine, norepinephrine and serotonin, and then when the effects wear off these neurotransmitters increase, which can induce euphoria and empathy, and improve disorders like ADHD or OCD for the duration of the rebound, (until tolerance develops of course). Many of the symptoms you listed sound consistent with a D/NE/S rebound and are different from the usual symptoms of baclofen overdose (vomiting, weakness, drowsiness, slowed breathing, seizures, itching, unconsciousness or coma, possible organ damage).

250mg in 24 hrs is a lot of baclofen either way - the maximum daily dose is listed as 80mg. I would really not mess around with taking more than your prescribed dose. I doubt there's a perfect dose that gives you the good effects without the bad effects. And if the beneficial effects you were experiencing were from a D/NE/S rebound, then perhaps a drug that stimulates D/NE/S instead of inhibiting them would be preferable. Isn't OCD normally treated with anti-depressants? What other drugs have you tried in the past?

One thing to note, having a half-life of 2-5 hrs doesn't mean that is equal to duration of action or that you can safely take it every 2-5 hrs. Half-life just means that in an average person half of the drug should be out of your system. It then takes the same period of time for half of what's left to be eliminated and so on.
 
Swimmingdancer said:
This is not really a basic question so I'm going to move it from Basic Drug Discussion to Other Drugs, which is for more intermediate questions (of drugs that don't have their own focus forums).


I had no idea baclofen was even used for OCD. I'm inclined to agree with you that this might be a rebound effect. As I understand it, baclofen, by it's action on GABA receptors, decreases dopamine, norepinephrine and serotonin, and then when the effects wear off these neurotransmitters increase, which can induce euphoria and empathy, and improve disorders like ADHD or OCD for the duration of the rebound, (until tolerance develops of course). Many of the symptoms you listed sound consistent with a D/NE/S rebound and are different from the usual symptoms of baclofen overdose (vomiting, weakness, drowsiness, slowed breathing, seizures, itching, unconsciousness or coma, possible organ damage).

250mg in 24 hrs is a lot of baclofen either way - the maximum daily dose is listed as 80mg. I would really not mess around with taking more than your prescribed dose. I doubt there's a perfect dose that gives you the good effects without the bad effects. And if the beneficial effects you were experiencing were from a D/NE/S rebound, then perhaps a drug that stimulates D/NE/S instead of inhibiting them would be preferable. Isn't OCD normally treated with anti-depressants? What other drugs have you tried in the past?

One thing to note, having a half-life of 2-5 hrs doesn't mean that is equal to duration of action or that you can safely take it every 2-5 hrs. Half-life just means that in an average person half of the drug should be out of your system. It then takes the same period of time for half of what's left to be eliminated and so on.
Click to expand...

Thanks for replying swimmingdancer. Ocd is normally treated with ssris. There are studies beginning to emerge showing the role of glutamate exacerbating symptoms. Baclofen also inhibits glutamate release from what I remember. I have tried ssris, atypical antipsycotics, amphetamines benzos, opiates, and a shit load of other drugs (both recreational and non) nothing has helped like memantine and baclofen. I'm going to have to drop the baclofen because of sides and fear of withdrawal, but the experience I had seems as if it'll stick with me. Like it was life changing.

How are you doing?
 
I also forgot to mention that while on the computer I got this feeling of clarity. As if I'm not living up to my potential, and that I am capable of much more. The feeling was so profound I began crying uncontrollably. I had to stand up and lean on the walk and take deep breaths it was so intense. But there were no negative feelings assosiated with it. No negative self talk what so ever. It was tears of joy multiplied exponentially. I will never forget the experience.
 
Sounds like my experiences on some psychedelics :). I hope this experience gives you some lasting help. I wouldn't try to replicate it again with the baclofen though.

Sorry you have tried so many prescription drugs and not found anything very helpful for your OCD. That seems to happen frequently with any mental issue. I have ADHD and a bunch of other issues (depression, chronic pain, fibromyalgia, sleep disorder, obsessive tendencies) and am exploring "alternative" treatments, things like non-drug treatments, supplements, traditional medicine (indigenous medicine, Chinese medicine, etc) and reading self-help books to try to change my thinking and rewire my brain, yoga, and so on. So far going this route has been far more helpful to me (and with far far less side-effects) than Western medicine and pharmaceuticals. But it does take a lot of time and effort, which is hard. A couple people in my family have OCD but their's doesn't sound as severe as your's, I only have it very slightly (not enough for a definitive diagnosis) but it seems to be improving.
 
I've gotten the empathy, profundity, sense of clarity, & meaning from to the point of tears GHB - which is a GABA B agonist, among other things. Baclofen above 140mg felt alot like the dizziness from my highest G dose. 90-120ish made me *very* motivated, optimistic - but not euphoric & a strong increase in sex drive.

I would use great care taking high daily doses of this. I used to take 60mg\day fairly regularly as an anticraving med (kept me off heroin & alcohol) I found that after 2 weeks at this dose a 2 day interruption in my pills would make me agoraphobic, emotionally panicky, & gave me pain in my carotid arteries.
 
Thanks guys. I'm going to stay away from the baclofen as a treatment option. The only thing I fer now is withdrawal as I've been using it in the 50mg range over the last 5 days. If the do come p, I ordered some phenibut just in case.

I've done some alternative work as well. Eckhart tolle has really helped me out in identifying and being aware of my ego. The more aware I am of it, the less of a role it seems to have in my life. I just ordered another book on ego. I also have a lot of negative self talk and was recommended a book called 'mind over mood' its a workbook all about our thoughts and how they influence our feelings. The exercises go into great detail, but like you said, it takes a ton of effort and its hrd for me to be consistent.

I'm glad you've noticed improvement swimmingdancer :-)
 
Some of these (the psychosis feelings & esp the symptoms of your OP) also sound like a textbook description of Baclofen withdrawal...due to it's very short half-life, and after a dose like that, I wouldn't be in the least bit surprised :/
 
soundphaRm said:
Some of these (the psychosis feelings & esp the symptoms of your OP) also sound like a textbook description of Baclofen withdrawal...due to it's very short half-life, and after a dose like that, I wouldn't be in the least bit surprised :/
Click to expand...

Thx. I agree. That was my reason on constant redosing, which like ghb and ghb analogues, leads to a vicious cycle.

I had some inderal on hand which helped with the cardiac/cns issues
 
GABAergics , lyrica, baclofen, gabapentin, klonopin oh my!

sirbishop said:
Thanks for replying swimmingdancer. Ocd is normally treated with ssris. There are studies beginning to emerge showing the role of glutamate exacerbating symptoms. Baclofen also inhibits glutamate release from what I remember. I have tried ssris, atypical antipsycotics, amphetamines benzos, opiates, and a shit load of other drugs (both recreational and non) nothing has helped like memantine and baclofen. I'm going to have to drop the baclofen because of sides and fear of withdrawal, but the experience I had seems as if it'll stick with me. Like it was life changing.

How are you doing?
Click to expand...

I couldnt get off opiates for ten years of trying. I finally got off methadone and was so repolsively sick that I was suicidal after two months. I crawled down to the computer, typed in google with shaking hands something to the tune of "withdrawal help..." . Eventually I navigated to the erowid page with the DXM faq. After doing the DXM a couple days in a row I felt at least 4 times better. I bring this up because you mentianed the memantin which Im pretty sure is an nmda antagonist like Dxm, Pcp, Ketamine, etc. Many prominent researchers in this field believe that nmda ant drugs actually lower opiod dependance making it much easier to deal with the withdrawal.
I am also prescribed baclofen for a cervical spine problem that is extremely painful and I cant get prescribed one for my life. The Dr makes too much money on giving her experimental steroid epidural shots. So I pretty much told her "Dr if your going to have me out here all the time to get no pain releif at all other than the shots Im not coming back. She was like "What do you have in mind?" I said I could really benefit therapeutically from some Soma because in between shots when the pain starts comming back there is nothing I can do.
Im also on Neurontin and Klonopin in addition to Baclofen which means my GABA system is getting bombarded from all angles which worries me.
Taking Baclofen is hard to do because you have to follow severely strict titration rules. Its related to GHB (pretty much the only common drug I still havent had).
The feeling could be REAL nice at times but when you get to the phase as I have many times, You can pretty much fall asleep in the middlie of taking a bite of a sandwhich. I actually have just been nodding half way through the word sandwhich. The hangover is an unexplicable feeling of discomfort. Maybe you could compare it to being hungover on drinking but waking up with zero memory and blood pressure dropped to the floor. I cant find hardly any information on how to properly take baclofen recreationally. There has to be a way, gaba B agonists are pretty rare. l
One more gripe. Why on earth did someone in such severe pain as me get prescribed my a PAIN MANAGEMENT dr, a medication that pales in comparision to opiods in safety and dependance liability. The dependance caused by Baclofen is one of the nastiest out there. It can be worse than benzodiazepine withdrawal syndrome and is oftern times deadly. Opiates if taken in pill form as directed are non toxic and if you stop taking them you will go through an awful withdrawal but you wont go through anything like you would with baclofen abstinence and with opiates there are many ways to counter the withdrawal syndromes.
If you take too much baclofen you feel like you cant think a straight sentence, your short term memory because anavailable, if feels like your blood pressure is so low, transient nausea, falling asleep while performing normal everyday tasks, and dysphoria. Now I found this at 80 mg's because I tend to push the limit when it comes to drug taking. But I honestly was taught a lesson because I felt horrible and I woke up on the floor in different areas of the house several times a day.

Ok lets say the dr has a hunch that Im an opiod user or past user.. Wouldnt it be better to prescribe pain medication that are opiod to someone who is opiate tolerant as to someone is opiate naive? If you are taking an opiate in a prescribed manor and not stopping it early it will cause basically zero problems. Maybe this is related to politics that relates to the wars in afghanistan where much of the opium is prepared for the thebaine that is extracted from the Poppy plant to be the base for 90% of opiate medication. So when you have a war in the Poppy Fields I am guessing that if you have a surplus there will be things produced like suboxone. It needs thebaine and then there is the center of the opiate drug ring with the old folks in florida and the pain clinics. A quasi legal opium trade. But I, with extreme pain must take a medication that can harm me every day for the rest of my life, so that they can the supply and demand balance of poppies to their advantrage. The Dr might as well just prescribed me xyrem or fentanyl patches. I would have at least regained my quality of life and had the privilege to live without the pill if at any chance I lose the Dr that provides it, I can go through a psychotic nightmare with a side effect of death. Boy I love the business ethics of the illuminati. Why cant I just have a dr that will write me a Rx of fentanyl patches or oxycodone hcl, not to get high, but just to feel better about being in severe pain constantly and to be able to go out and work again. This system is so ass backwards.

A few questions about my new baclofen script (15mg tid)/ How can I take it recreationally? Is there a way to get it to feel like the GHB I hear so much about? Ive done almost every chemical out there except for most psychedelic anticholinergic hallucinogens and many of the 2c(x) series of phenethylamines. So I have a lot of experience with basically every drug but the gabaergics really confuse me. I just had a full bag of prescription bottles of lyrica and went through almost a 100 75mgs in a couple days. So I had to tell my doctor that I needed back on gabapentin because I get a ton more of it and it doesnt have that "I wanna chase the first high" feeling to it. If you stagger gabapentin that could be spectacular. The klonopin works on gaba subreceptor bz. I love how that feels. Now the baclofen is a GabaB agonist and I cant figure what id does or why it does it, if anyone could help I would greatly appreciate.
Thanks a million, :?
Much Love,
@sp0r412
 
does anyone know if baclofen is legal in 2012 but supposedly 3/13/2012 it was made shedule 2, does anyone know for sure
 
I had an experience with baclofen which i wrote down. Here it is :
25 june 2013
10pm 30mg
26 june 2013
12:35 - 55 pm 70mg
~13:45 60mg
14:45 40mg
14:56 : man, life so good
Sedated, happy, quite euphoric, no nausea. Everything's pleasant. Music appreciation is increased significantly.
Talking is slightly slower. Communication almost not affected. My mom didn't notice a thing.
15:22 another 40
Effects similar to alcohol with codeine
15:57 starting to get nauseous... Took 1 librax
27 june 2013
12:01 pm finally able to eat and drink as much as i'd like
This was a crazy experience. Baclofen has alot of potential, but the come down was terrible. Especially because of that high dosage. I didnt regret my experience. But i will certainly not do it again anytime soon. Yesterday i fell asleep at about 4pm. Woke up at 8:30pm extremely nauseous and vomiting repetedly. My parents called the doctor without my consent. Checked me, everything was fine but my pupils. They were dilated. I denied having taken anything. But he knew i did, and wanted me to take a urine sample. He then left at about 8:45pm and I fell asleep 5 minutes later. Woke up today at 6am. Much better and gradualy kept getting better. Now i'm almost fine. Still gotta wait few hours till the last bit of nausea goes away. It was well worth it. But I will not do it again as I said previously.
Weight : 130lbs
 
I've taken WAY more than that, probably 65%-75% more and it had a very delayed onset which is why I kept taking it after about 2-3 hrs of the previous time, taking 8-12 at a time. Well morning time came and I couldn't move a muscle in my body, not even a little, maybe a finger. So I laid stuck on the bed like that for about 12-15 hours unable to move, confined in my body, only able to wonder why my lungs were still working and my heart still beating if I literally couldn't even lift my head or close my mouth. I could blink my eyes, but I just told myself that I couldn't have a panic attack which in extremely prone to, for fear of my heart not being able to beat correctly in it's state of diminishes capacity, so I did my best to sleep, waking up (well not really sleeping much bit becoming more aware of myself) every few hours, until almost 5:30 that night that I was able to get out of bed. My blood pressure was just dangerously low.
 
I still get a regular electronic submitted rx to mg pharmacy, the shed 3 has to be on a printed or hand written rx pad and the sched 2 has to be hand written in triplicates, so, no, Baclofen isn't a narcotic.
 
issokay said:
I've taken WAY more than that, probably 65%-75% more and it had a very delayed onset which is why I kept taking it after about 2-3 hrs of the previous time, taking 8-12 at a time. Well morning time came and I couldn't move a muscle in my body, not even a little, maybe a finger. So I laid stuck on the bed like that for about 12-15 hours unable to move, confined in my body, only able to wonder why my lungs were still working and my heart still beating if I literally couldn't even lift my head or close my mouth. I could blink my eyes, but I just told myself that I couldn't have a panic attack which in extremely prone to, for fear of my heart not being able to beat correctly in it's state of diminishes capacity, so I did my best to sleep, waking up (well not really sleeping much bit becoming more aware of myself) every few hours, until almost 5:30 that night that I was able to get out of bed. My blood pressure was just dangerously low.
Click to expand...
Wow-that sounds very scary-dangerous. When you have taken so much that it does that to your body; where you can't even crawl out of bed-is there a chance of baclofen doing any possible permanent damage after a situation as this?

That would be a constant worry of mine.
 
No I think the reason I couldn't move was because my blood pressure was really really low. I'm not going to be doing it again though. It's getting fucked up but it's not any fun.
 
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