Harm Reduction OD Question.

[Diloadid]

Just a question, and not it isn't pertaining to drug test, just more of a general question that I have often wondered.

Are drugs passed through your system faster when you IV them? I mean, I assume so because drugs IV'd bypass the first pass metabolism.. I think.

Or is it that people are just junkies and feel much more sick when they have no more dope left? So automatically enter a state of panic and sickness that is mentally induced from going without?

Maybe I can get an accurate answer to this question. Thx.

Edit: Also I am not wondering about how long you will be high when drugs are IV'd. More or less wondering if drugs are cleared from your body faster when IV'd. Because when you use Oral/Insufflation It seems easy to go a day or two without using where as it is almost impossible to go a day without using when you IV.

 

[sekio]

Are drugs passed through your system faster when you IV them?

Nope.

A lot of overdoses come from product purity suddenly changing, people changing locales, or people losing their tolerance (detox/prison) and relapsing with an amount too large for them to handle.

 

[Diloadid]

Hmm, this seems odd to me because when drugs are IV, aren't they metabolized differently than other ROA's? I mean I'm not trying to argue but I guess it is understandable to question it... maybe?

 

[tricomb]

Hmm, this seems odd to me because when drugs are IV, aren't they metabolized differently than other ROA's? I mean I'm not trying to argue but I guess it is understandable to question it... maybe?

Why would it be metabolized differently when administered by IV? Like, what makes you question it?

 

[bronson]

No matter the ROA it still eventually crosses the blood brain barrier and enters the bloodstream in order to be psychoactive. Thus, in the end it's metabolized in the same way.

 

[Znegative]

Well, it actually will leave the system faster I believe in most cases, as when most drugs are injected, they begin to get metabolized immediately, wheras with other ROA, the metabolization does not occur until the drug has peaked. So while the half life will not change, the duration will offten be shorter. A prime example of this is buprenorphine.

Buprenorphine has a long half life (36 hours), and when taken through almost every ROA aside from IV, the duration is very long as well. Howevere, most people who Iv bupe have to do so multiple times a day (especially if they are injecting small dosages). So while it appears that the elimination time changes when a drug is administered intravenously, it s actually just that the drug begins to be metabolized almost instantly, causing the shortened duration and earlier onset of withdrawals.

 

[Diloadid]

Well, it actually will leave the system faster I believe in most cases, as when most drugs are injected, they begin to get metabolized immediately, wheras with other ROA, the metabolization does not occur until the drug has peaked. So while the half life will not change, the duration will offten be shorter. A prime example of this is buprenorphine.

Buprenorphine has a long half life (36 hours), and when taken through almost every ROA aside from IV, the duration is very long as well. Howevere, most people who Iv bupe have to do so multiple times a day (especially if they are injecting small dosages). So while it appears that the elimination time changes when a drug is administered intravenously, it s actually just that the drug begins to be metabolized almost instantly, causing the shortened duration and earlier onset of withdrawals.

Ah. Thanks Znegative. It was just a question that stirred my curiosity.