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"3,4-methylenedioxy" analogue of propylhexedrine: a good idea?

I guess the vendor could create a wiki page giving the basics and then a real person can try it based on the recomended dosage and post a TR indicating that it may be active but nowhere near as cool as the vendor's wiki page lead them to think...
 
It's going to be unstable, garbage, fake, or all of the above. Steric hindrance around MDMA's methylenedioxy group seems to be detrimental as evidenced by the decreased affinity of (difluoromethylene)dioxymethaphetamine/(ethylidine)dioxyM-AMP.

There's also the issue of the supposed 3,4-MDPH having 4 chiral centres. 16 isomers. I doubt all of them are active.

That's also 16 N-desmethyl metabolites, 48 (16+16+16, one to 3-MeO-4-OH, one to 4-MeO-3-OH, one to 3,4OH) ring opening metabolites, and another 48 N-desmethyl+ring-opened ones.

What a spectacular cocktail. 128 drugs in one, and that's just getting started. I would definitely avoid this if it is anywhere close to racemic (which it will be, because doing chiral synthesis is going to be a bitch).
 
Astavats said:
Translation: 'I want to try this but I'd rather someone else risk their live first.'

Why isn't there a rule against this - if there is why is it rarely enforced? This is nothing more than 'personal harm reduction'.

There is no necessity to announce the availability of this or any other compound. It's very simple; those interested will probably find it (or something representing it) on their own. Those who find it may attempt to acquire it. Those who do and consume it will probably report on bluelight, another forum or somewhere on the internet. Fortunately google will make locating information much easier so there is need to rush into the unknown.
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OK, I'll rephrase this. I have been following this thread which appeared to have come to a dead end six months ago (for the good reasons outlined by several contributors) when I noticed that the compound being discussed hypothetically was likely to become available for research. I thought this would be the place to mention this, albeit that I maybe did so in a glib manner. I am not advocating that anyone should take an untested compound.
 
I wonder if adding a b-keto on levopropylhexedrine would make it smoother/more dopaminergic rather than adrenergic...?
 
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Is there any reason to believe that it should? Inferring naively from amphetamine SAR, we should not expect the addition of a beta-ketone to make a compound less adrenergic.

ebola
 
ebola? said:
He responds to more sensible dosage-levels. Also, never swallow the cotton, as you risk impacted intestines.



Things are more complex than this. Look at the structure for phenmetrazine and how different it is from amphetamine. Why would we expect similar SAR?

ebola
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Because the ring structure of the morpholine holds the aryl group and the amine function in the same relative positions as occurs with MDMA. Also, it's also known that beta methoxy substitution still allows compounds to interact with serotonin receptors. MDPM is basically beta methoxy MDMA that has been made into a heterocycle. Finally, phenmetrazine is a dopamine releaser, not just a reuptake inhibitor :It's things like MD-methylphenidate have no chance of acting like MDMA
 
I've not done any chemistry since AS Level, but there must more interesting theoretical possibilities for MDxx style enpathogen/entactogens than just slapping a 3,4-MD group on a random stimulant?

Just look at at MDPV and MDBZP...
 
But methylenedioxy rings are a guaranteed way to turn any chemical into a powerful MDMA analog! Everyone knows that </sarcasm>
 
indeed..., for example
ntemp.gif


*cough*
*flee away from the thread* </sarcasm>
 
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Clearly, more methylenedioxy groups are better, so I propose SUPER-MD-BENZO-FURY GRANULES! 3000 times the potency of LSD and meth! Anyone got a vendor for this????????????????????????
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Would I be wrong in thinking that 2-phenylpiperazine would be a phenethylamine analog and that these other benzyl/phenyl-pipes on the market are not..?
 
Another interesting question is whether or not attaching a methylenedioxy group to a methylphenidate molecule would be beneficial in any way.
 
It's an easily answered question, as if you look at the 3d structure of methylphenidate, at no point does it resemble common substituted phenethylamines. Thus, 'slapping a 3,4 methylene-dioxy on that bad boy' doesn't make sense for conferring affinity for the serotonin transporter. And then you have the issue of reuptake-inhibitor SAR being just plain different from releaser SAR.

ebola
 
Not sure about the chemistry going on, but I know the vendor being mentioned in here a lot, and i'd just like to say : just because someone selling drugs tells you that it's chemical xyz, doesn't make it so.
 
nAON said:
Not sure about the chemistry going on, but I know the vendor being mentioned in here a lot, and i'd just like to say : just because someone selling drugs tells you that it's chemical xyz, doesn't make it so.
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Sad but true unfortunately. Everyone is out to make a quick buck (and its a HUGE business) and a lot of people get burned in the process but unlike a normal credit card transaction where you can dispute it - what's the dispute? "Uhhh I bought this chemical online that is labeled NFHC and I ate it and it was bunk or did bad shit" Yeah right.
 
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