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[MEGA]Idiosyncratic/Unusual Responses to Cannabis

Not sure if this is thread worthy in its own, but yes sometimes when I'm intoxicated (more-so on coke/alcohol than weed, but sometimes weed) when a burp is coming up I think I'm about to be sick, but then I just burp and smoke/snort/drink more :)
 
Sudden onset of severe cannabis hangovers

Over the past 15 years (I'm now 37), I've smoked an average of 2 - 3x/week, never more than once per day, and almost always in moderate doses. One of the things I've most prized about cannabis is the complete lack of any negative aftereffects. This changed suddenly and drastically for me about two months ago. I now get a debilitating, day-long hangover from smoking even small quantities.

It's worth noting that about two months prior to the onset of these hangovers, I altered my smoking habits considerably. Instead of my normal one-hitter, I began smoking out a bong. With the one-hitter, I'd very roughly estimate that I typically smoked around 0.05 grams (1/20th of a gram). When I switched to the bong, I probably doubled or tripled this. I also started smoking more frequently, averaging perhaps 4x/week (though again, never more than once per day).

After about a month of this, I felt I might have started noticing some general sluggishness, both mental and physical, but it was subtle enough that I couldn't definitively state it was even present, let alone conclusively attribute it to my smoking.

But after another month, the effect suddenly became unmistakable. Literally overnight, I started getting these really incapacitating hangovers. I felt utterly exhausted the entire next day after smoking and my mind felt very foggy and unfocused. I'd never experienced anything like it, on any drug. There was a perfect correlation with my smoking: whenever I smoked, I had a hangover the next day, and whenever I didn't smoke, I felt fine the next day. The hangovers invariably lasted an entire day.

I therefore decided to put away the bong and revert to my previous smoking habits (0.05g via one-hitter) in terms of both method and quantity. To my surprise, I still got the hangovers, even though my regimen was the same one I'd had for 15 years with no hangovers. I then took an eight day break from any smoking, then tried the one-hitter again. The hangover was as bad as ever. I took another 8-10 day break, and once again tried the one-hitter, but this time at a very low dose, approximately half what I'd typically smoked (i.e. about 0.025 g). Again, the hangover was as bad as ever. I repeated this process, taking another week off before once again smoking a very small dose. Once again, terrible hangover.

I've searched both this and other forums extensively and really can't find anything quite like this. Certainly others report hangovers, but I can't find anyone who experienced such a sudden and dramatic onset. That's what particularly puzzles me about this: how quickly it came on. Obviously I'm not blind to the correlation between this onset and the change in my smoking habits, but it's odd that these hangovers would persist even after I've reverted to my old habits which never produced any hangover (and as noted, these hangovers now happen even at approximately half my old "normal" dose). The only explanation I can come up with is that there was some sort of build up of something (THC, some "toxin", who knows?) when I increased my intake, and that even now, when I've smoked only three times in the last month, all at very low doses, that build up still hasn't dissipated, and these relatively small doses somehow push me over the edge. That doesn't seem entirely plausible, so I'm hoping others can shed some light on this. Bottom line is I value cannabis for many reasons, and I really don't want to have to quit entirely.
 
I get these hangovers as well, didn't used to be like that, but nowadays it just happens. Not sure when it exactly happened, but at some point I just noticed that I'm getting clear hangovers that are distinguishable from the day after effects of cannabis I was used to. I'm thinking there's a reverse tolerance to certain effects of cannabis, your body/brain gets sensitized to them over time, especially with higher doses. This would, atleast in my eyes, explain these hangovers and the fact that sometimes heavy smokers suddenly start getting super anxious from weed and have to stop, despite smoking years without a problem. Definately more plausible than some toxic build-up and to me it would seem reasonable that abstinence wouldn't necessarily reverse this sensitization, in fact it should be the opposite because your receptors aren't getting any exposure.

If I take a good break, say, ~2months (which is the longest I've had in the past 5 years or so) I get ridiculously high from ridiculously low amounts of low grade cannabis products such as leaf material which many people just throw away. It gets very trippy and psychedelic, visuals and all which I normally never get. This definately did not happen to me when I first started smoking cannabis, if it did, I probably never would have needed to smoke buds anyway.
 
Vaporizing oil/extracts/weed is the best way to avoid "cannabis hangover". Also, try to limit your intake. If you're not a seasoned, 8th a day smoker, then you shouldn't have to worry about how much you're smoking, just that you are smoking it, not vaporizing / eating it. %)
 
I get these hangovers as well, didn't used to be like that, but nowadays it just happens. Not sure when it exactly happened, but at some point I just noticed that I'm getting clear hangovers that are distinguishable from the day after effects of cannabis I was used to. I'm thinking there's a reverse tolerance to certain effects of cannabis, your body/brain gets sensitized to them over time, especially with higher doses. This would, atleast in my eyes, explain these hangovers and the fact that sometimes heavy smokers suddenly start getting super anxious from weed and have to stop, despite smoking years without a problem. Definately more plausible than some toxic build-up and to me it would seem reasonable that abstinence wouldn't necessarily reverse this sensitization, in fact it should be the opposite because your receptors aren't getting any exposure.

If I take a good break, say, ~2months (which is the longest I've had in the past 5 years or so) I get ridiculously high from ridiculously low amounts of low grade cannabis products such as leaf material which many people just throw away. It gets very trippy and psychedelic, visuals and all which I normally never get. This definately did not happen to me when I first started smoking cannabis, if it did, I probably never would have needed to smoke buds anyway.
Thanks for the reply. This reverse tolerance hypothesis seems somewhat plausible, but it doesn't really explain why these hangovers seem to initially have been brought on by my smoking higher-than-normal (for me) quantities. Also my tolerance to the desired effects doesn't seem to have decreased at all. The only thing that's changed is these sudden hangovers.

One question, when you returned after taking a two month break, did you still get the hangovers?
 
Vaporizing oil/extracts/weed is the best way to avoid "cannabis hangover". Also, try to limit your intake. If you're not a seasoned, 8th a day smoker, then you shouldn't have to worry about how much you're smoking, just that you are smoking it, not vaporizing / eating it. %)
Appreciate the suggestion, but this really doesn't address my main question: why, after smoking thousands of times over 15 years without any aftereffects, I suddenly have debilitating hangovers from even a fraction of my typical dose. Perhaps vaporizing would help a bit, but I don't think my method of intake explains the sudden hangovers since it's been the same for 15 years.
 
Thanks for the reply. This reverse tolerance hypothesis seems somewhat plausible, but it doesn't really explain why these hangovers seem to initially have been brought on by my smoking higher-than-normal (for me) quantities. Also my tolerance to the desired effects doesn't seem to have decreased at all. The only thing that's changed is these sudden hangovers.

One question, when you returned after taking a two month break, did you still get the hangovers?

Yes and it only seems to get worse as time goes by, most recent addition being insomnia the day/night after. I'm getting worse but slightly different hangovers from vaporizing, it usually results in higher blood-levels of cannabinoids and less by-products from ignition, the cannabinoids are definately worse for me. Edibles... the effects last so long I can be off for days. It's almost as if like taking cannabis briefly disturbed/upset the endogenous cannabinoid system in the areas where it affects it and this disturbance would last beyond the acute effects, depending on for example dosage. Body/brain freaks out a bit. I usually need to gain some tolerance to the effects for them to be enjoyable, exception being if I take ridiculously low amounts.

Long term reverse tolerance to certain effects along with acute tolerance to some? The reverse tolerance leading to things like certain CB receptors being so sensitive that they freak out really easy, the acute tolerance leading to things like dampening of cognitive effects.

EDIT: Maybe there is sort of a threshold, before the receptors start freaking out sorta simultaneously, all at once?
 
check out the mega quitting thread, you are not alone in this.

Merging into mega unusual responses to cannabis
I did read the quitting thread fairly exhaustively, and found nothing like this. I found people quitting due to negative effects, but nothing similar to my specific situation (after 15 years I suddenly have debilitating hangovers from even a fraction of my typical dose).
 
Yes and it only seems to get worse as time goes by, most recent addition being insomnia the day/night after. I'm getting worse but slightly different hangovers from vaporizing, it usually results in higher blood-levels of cannabinoids and less by-products from ignition, the cannabinoids are definately worse for me. Edibles... the effects last so long I can be off for days. It's almost as if like taking cannabis briefly disturbed/upset the endogenous cannabinoid system in the areas where it affects it and this disturbance would last beyond the acute effects, depending on for example dosage. Body/brain freaks out a bit. I usually need to gain some tolerance to the effects for them to be enjoyable, exception being if I take ridiculously low amounts.

Long term reverse tolerance to certain effects along with acute tolerance to some? The reverse tolerance leading to things like certain CB receptors being so sensitive that they freak out really easy, the acute tolerance leading to things like dampening of cognitive effects.

EDIT: Maybe there is sort of a threshold, before the receptors start freaking out sorta simultaneously, all at once?
I'm not entirely following - what threshold exactly are you referring to? Are you saying that there's some sort of build up of certain compounds over time, and this build up reaches a threshold.

I guess that's still what puzzles me most, is how there seemed to be some sort of tipping point, before which I NEVER got hangovers and after which I ALWAYS get incapacitating hangovers, more or less independent of dose. It just doesn't make sense based on any mechanism I can conceive of. Though granted, my knowledge of this stuff is very limited compared to some here, which is why I posted this.
 
I'm not entirely following - what threshold exactly are you referring to? Are you saying that there's some sort of build up of certain compounds over time, and this build up reaches a threshold.

I guess that's still what puzzles me most, is how there seemed to be some sort of tipping point, before which I NEVER got hangovers and after which I ALWAYS get incapacitating hangovers, more or less independent of dose. It just doesn't make sense based on any mechanism I can conceive of. Though granted, my knowledge of this stuff is very limited compared to some here, which is why I posted this.

Yeah basically I meant that maybe there is somekind of tipping point, that the receptors can tolerate a certain amount of exposure, until a certain treshold, before you start getting these hangovers. Bit like allergies can get worse over time with the you're exposed to your allergens. Don't think there would be any significant chemical buildup, except for inactive metabolites. Feels really, really speculative though hehe. This thingy had me thinking a lot last night in the bed though, and one thing that crossed my mind also was that the sheer amount of different cannabinoids, psychoactive terpenes etc in cannabis add extra difficulty to this issue. The body should have a different reaction to each one of them as well as their combination, not to mention all the psychoactive metabolites such as 11-OH-THC, meaning that the body should develop different tolerances for each of them I'd guess.

I think more data is needed before it's reasonable to start these guessing games, such as little self-experimentation to see if certain things affect the hangovers and how. Such as dosage, method of ingestion, and time of dosing. I'm pretty sure I get worse hangovers if I smoke/vape right before going to bed, but I should verify it I suppose. Although I would say all kind of speculation is good because it might point us to the right path of researching, after all we do need some premise :P

The point of this 'research' would be to find what's actually causing these hangovers, where does the problem lie? Then we could proceed to finding out the cause for this rapid onset of hangovers.
 
Moderate Drug User hits a bong of weed, 5 minutes later had a seizure(?!) - advice?

Hello Bluelight! Long time lurker here, used BlueLight to handle a variety of questions in my experimentation in the past.

I had an exceptionally strange seizure-type event last night that I felt compelled to make an account and post it here, and would welcome any relevant feedback. I have spread 50 or so drug experiences out over the last 3 years, nothing really crazy - for a few weeks was using DMT on a twice-weekly basis, and took 2c-e on 3 occasions. Smoked weed heavily for two years, in the last year or so smoked around a cut a month.

Last night, I was hanging out at a friends place, all having a good time, drinking some vodka / fruit juice drinks, listening to good music. The host offered me a bong (trusted person and weed from a trusted source), and I took one big rip. I hadn't smoked for at least 4-5 days before that, so I got pretty stoned on that one giant bong rip. I turned down the second, because I didnt want to be too stoned to interact with the large group of people that was there.

About 5 minutes after taking this rip, I noticed that my ears had started really hurting. I have some mild hearing damage from being a nightlife photographer, and wear earplugs to prevent further damage when I go to events now, so it wasn't entirely unexpected. I go into the bathroom, and realize that I was feeling really weird. It reminded me of an occurrence where I once smoked what I thought was weed, but was actually laced with some other substance which caused a very speedy, 4+ hour high (potentially meth? or "dipped" weed). The pain in my ears was getting worse, and I was wondering if perhaps I had punctured my eardrum or something like that. I believe I was sitting on the bathtub, when suddenly my vision started to go dark around the edges, rather quickly. I was compelled, on some basic survival instinct level, to try to get out of the bathroom, because I was concerned if I passed out in there that no one would find me until it was too late. I moved towards the door, but my vision dropped totally out as I was reaching around to try to find the handle to the bathroom door. I was left leaning against the door, and I remember hearing my own body smacking against the door as my arms and legs moved on their own accord, making small jerks. I managed to stay leaned against the door for this to avoid falling over.

I was like this for what I would guess to be 5-10 seconds, before my vision cleared enough for me to open the door handle (This I do not remember), and stumble into the hallway
(do not remember). I was able to walk, but was aware that my legs were not moving like they normally did, as I announced to the other 5 people in the room that I thought I was having a seizure(I remember this and everything to follow). They gave me a glass of water, and told me that I looked extremely pail. I sat on the couch and recovered - it clearly peaked and then cleared up after. I watched a movie there while they went to the nearby Big Gigantic show, and about 3 hours later, drove 3 hours to my apartment without trouble.

So, wisdom of the internets, have you ever heard of this type of experience? A potential cause of this would be about 3 months ago, I took 3 hits of what I thought to be LSD - around peak, and less than 5 minutes after smoking a bowl of weed, I developed a searing pain on the right side of my head, felt like it was in my brain itself. i assumed that I was given some badly-made RC and simply took a month off. I have had some very, very mild headaches that were almost not noticeable in that area on my head, but just assumed that they were related to the hearing damage. I guess in retrospect, that it might have caused some sort of permanent brain damage that results in this when in these altered states? :?

I have 7 hits of this substance remaining, could I send them somewhere to get the chemical contents tested? Many thanks in advance for your advice!
 
I know you said the weed was from a trustable person but I think it was laced with something. I've never heard of weed doin that. Weed, pure and "clean" seems to be the safest drug, IMHO.
The lsd on the other hand makes your brain bleed, that's how people "trip". I could see that givin you problems.
 
I know you said the weed was from a trustable person but I think it was laced with something. I've never heard of weed doin that. Weed, pure and "clean" seems to be the safest drug, IMHO.
The lsd on the other hand makes your brain bleed, that's how people "trip". I could see that givin you problems.

BabyGurl, I do hope you are kidding about the LSD? It is a perfectly benign drug. In any event, to the OP, it sounds like you underwent some sort of uncomfortable experience which could have been a seizure, or could have just shared some of the characteristics of a seizure. I don't know if you have a history of seizures, and have not heard of cannabis inducing any seizures, but I assume it is possible that your first seizure could have coincided with cannabis use. Again, I am not sure what you suffered was indeed a seizure, although they do come in a variety of forms. If what you smoked wasn't just cannabis, this incident could more easily be explained, though you said it was a trusted source. In any event, due to your apparent concern, I would look into getting any EEG to look for any abnormal electrical activity in the brain.
 
There is no causal evidence to prove that it was the weed that induced the seizer. It may have, it may not have. Regardless if you are having seizures you should consult a real doctor, as that is a serious medical symptom from ailments that are best treated in early stages.
 
I'd go to a doctor. First off, if it was last night it's possible that a blood sample might still show positive for any toxins/drugs you may have ingested. Additionally you will want to make sure this was not a symptom of something more serious.

I had an experience once on an airplane. I had drank about 7 beers, then ate a meal on board. I asked for another roll and they brought me an entire meal, so I ate it. Heh. About 15 minutes later I felt really sick. I was sweating and felt like I was going to puke. I walked to the bathroom, and developed tunnel vision on my way. I reached for the door and everything went black. I can vaguely remember hitting the floor. When I came to there were a couple of stewardesses next to me with oxygen. My doctor referred me to an otolaryngologist (ear, nose and throat specialist) who ordered a whole battery of tests. Everything came up clean so I assume it was just a result of alcohol and fatigue. At least I know it wasn't epilepsy or a tumor.

Go to a doctor and get checked out. Good luck!
 
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