I've taken noscapine in very high doses, both alone and in combination with other opiates, morphine, oxycodone and hydromorphone. If it did anything at all, it wasn't very noticable, nothing spectacular anyway.
Ah well then. I'll still try it but now I'm not too excited over it. I
think it's OTC in Peru so I may have to source it from there.
I see you're on a serious quest to get higher here! Many people are curious about sigma receptors, I can see why you'd want to try this and aside from a general harm reduction attitude nothing would really keep me from reaffirming you in that quest. :D Opipramol does indeed make for some weird combinations, e.g. it reliably gives me serotonine syndrome combined with tramadol which on it's own has neglible serotonergic effects on me compared to the opioid goodness it's metabolite o-desmethyltramadol unleashes.
I'm not on a mission to get higher, just to learn how sigma works and how it affects other compounds. I've been all the way to the top so getting the "ultimate high" really isn't on my to-do list. The research is so interesting though, it's like you're looking into a black hole with a tiny bit of light at the end. I want to see that light. It's about discovery more than anything else.
Interesting about Opipramol, serotonin syndrome would be the first thing to come up when combining it with the usual drugs but I think when combining it with benzos it could hold a lot more facets. Again though the 3 would be tested against one another to see if it's the s1 or s2 that's increasing the activity. I sure as hell won't be touching it with serotonergic compounds though. I've been put off serotonin lately (releasers mostly, the receptors I still love) so it'd be dopamine or GABA principally. I /may/ have a go with some psychedelics just to see if it affects them in any way, but the most benign psychedelics at that, no 2C-T-x's or aMT type compounds. MAOI is a great threat level when working with sigma agonists, it could completely caffell (EDIT for comprehension: fuck you over!) you.
Why the need for PRE-084 if you already have two sigma agonists? Those could be a starting point and you could still go for PRE-084 from there.
Simply because it seems a lot more selective than the others that would be used and of course because it's use has not been tested yet, so someone needs to be a guinea pig!
As for other drugs, there are plenty. Amphetamine would be another one on the stimulant side that gives very reliable effects.
Is amphetamine not a sigma agonist itself? I was thinking about it but IIRC it is a sigma agonist. If not then it would be adequate for me to use.
I can see why you don't want to IV (I personally just stay away from IV opiates, but e.g. dissociatives are ok), but are you sure PRE-084 is orally active? I haven't checked.
It may not be orally active, but insufflated it may be. It is water soluble and if needs be I'll add some Chitosan to increase bioavailability to try to get the most out of it.
Btw almost all of these recreational drugs that seem to bind to sigma receptors are highly habit forming, why would you want to take that risk when you don't trust yourself with IV'ing? Benzos cause some pretty severe dependance issues when taken on their own already. In a worst case scenario, you'll have a much bigger problem than before.
Don't worry about that, I already have a pretty heavy benzo dependance, I am however worried about increasing my tolerance to them. It could drastically alter my tolerance thus creating a much larger problem but I would use it alongside NMDA antagonists (such as ketamine and MXE, outside of the experiments) to help reduce tolerance via the Nociceptinergic pathways, if I am right in thinking that is what causes tolerance?
I just want to get to the end of this, as I've been theorising over sigma agonists for a good two years now and I really want to get some solid (in vivo) evidence of either non-enhancing activity or enhancing activity. It's a thorn in my side that I just want to be over and done with! Even if I produce no significant results I'll be happy that I tried and completed this age old theory of mine (and others'!).
