Apparently it is possible. Just Google 'smoking scopolamine' and you can read some trip reports. One factor to consider would be whether one plans on crushing up scopolamine tablets of a known dosage, or using plant material from the Solanaceae family (genus Datura or Brugmansia. Plant material is renowned for having wildly varying ratios of scopolamine, atropine, hyoscyamine and other anticholinergic alkaloids. This makes it very hard to titrate the dose accurately. If one plans on using tablets, the solubility depends on whether you have the hydrochloride salt, etc. It is alleged to have been done successfully with 1 20mg. tablet.
Just remember, this is not the chemical you want to overdose. It can kill you, and said death from hyperpyrexia and seizures is not pretty. From personal experience with dried Angel Trumpet leaves, this chemical is the only substance that gave me true hallucinations, where I knew who and where I was but truly believed what I was seeing was real. I watched the room fill with bugs coming from the baseboards, all swarming toward me. Not wanting to be eaten alive by these 'bugs,' I finally worked up the courage to bolt barefoot through them, right out of the house. I called my family and told them to send an exterminator, and a damned good one. I almost had a heart attack. When I went back inside, there were raccoons, squirrels, and other assorted wildlife making all sorts of weird calls and noises. They had taken over the house. There was no insight like that found with the phenylethylamines, no joy whatsoever. Just abject terror. This shit was flat out terrifying. I would never do it again, for any amount of money. Please, tread carefully. And BTW, physostigmine is the antidote for anticholinergic poisoning. Best given by a doctor, but why go there?
