Lol @ The wire. It is true though. Are you looking for the most notorious or the top sales? I'll list both, some notorious, some not so notorious but still large on the drug scale-
New York City, NY -- and subsidiaries (bronx, brooklyn, etc)
Camden, NJ
Newark, NJ
Chicago, IL
Baltimore, MD
Los Angeles, CA
Hollywood, CA
A lot of texas due to the mexico border. The big Cities even towards the west as well.
Las Vegas, NV
Miami, FL
Anchorage, AK
Seattle, WA
Detroit, MI
New Orleans, LA
There are definitely more, those are probably the largest drug hubs that I can think of. People might wonder about alaska but you wouldn't believe the amount of drugs that make it up there. Expensive, but trust me, plentiful. I lived there for many years.