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Opioids The Ultimate Opiate Potentiation Thread v2.0

Thorazine is chlorpromazine right? I imagine it'd aid the nod but typical neuroleptics are something I wouldn't envisage adding to opiates.
 
Bioperine is definitely one of the best potentiators I've ever used. It spikes the bioavailability of just about every pill, herb, and supplement. When mixed with diphenhydramine, oxys seem to nearly double in strength. All using legal supplements. You can find Bioperine at most Vitamin Shoppes
 
PillBlaster, your post gave me hopes...I know piperine, (black pepper contains about 9% of it) is a CYP3A4 inhibitor, i've tried to potentiate fent with cyp3a4 inhibitors, i had very good results with the strong ones, bioperine sounds cool to me..think i'll try it.%)

MartinFn
 
I forget to mention my opinion about hydroxyzine, as i see that a lot of people says that it works great..i've tried it at doses from 50-125mg, it didn't make shit, diphenydramine too. (But i'm talking about fent potentiation, don't know with other opiods..). And of course, everybody's reaction to one certain drug may be much different, so that's maybe doesn't mean anything, it's just my personal opinion (well, it's not an opinion, it's a fact, cause i turn myself to guinea-pig and try it, with no results, but anyway..:)). Hallo to all BL nation.:)


MartinFn
 
Quick question I have a bottle of fioricet 5mg and only 2 Endocets 5mg. If I'm reading right the fioricet can be a potentiator to Opiates if so how much should I use for 2 5mg Endocets? Ahh shit I wish I had a better stash right now but this is what I'm working with so I mite as well try n get the best out of it. Any help would be appreciated.
 
The d-phen is making the morphs last up to a whopping 16+ hours!!! I LOVE this shit man!!! Hahaha!!!!

Also, I start to peak at 7-8 hours, with a powerfully slow build up that starts at about an hour after administration.
 
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AlaskaThunder said:
The d-phen is making the morphs.....
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By this I assume you mean the D-phenylalanine (isomer)? I personally found it increased the duration of a noticeable effect* yet no increase of the peak concentration levels let alone for any extended time amount at these levels which seem (concurrently or separately) doubtful. The analgesics properties of D-phenylalanine are thought to be via a reduction in the enkephalin degradation (enzymatically, not important here) of which predominately effects DOR (delta opioid receptors), whilst morphine more closely mimics the endogenous endorphins and hence has affinity to MOR (μ-opioid receptor). DOR of which are not known for their euphoric effect.

I would presume your slow peak (a 7 -8 hour peak on morphine - no matter what ROA - is extremely long!) would be due to the slow degradation of the morphine. And lasting effect more a psychosomatic response. Sorry mate.




* Which makes sense since I'm on bupe which is - in addition to all the other opioid-receptor activity - is a DOR (δ-opioid) receptor antagonist so the prevention of this would cause an extended effect. :)
 
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i have tolerance to oxycodone and dilaudid, in the range of 30mg oxy and 16mg dilaudid. i like to take 2 robaxacet 8s with them but dont feel a big boost like i used to with oxy, with dilaudid its different. so i got some benadryl 25mg a pill, would it be safe to take 2 robaxacet 8s (325 acetaminophen, 400 methacarbamol, 8 codeine) one 25mg benadryl and 40mg oxycodone. i never took 40mg before but 30 dosent do much anymore.
 
I take a strong antihistamine called atarax hydrocosine 25mg x 3 prescribed for idiopathic anaphylaxis and I find they make a huge difference to the feeling of calm disassociation when taken with oramorph and tramadol. Have been told by specialist that the amount of drugs (prescribed) I take would drop an elephant !
 
Sorry for the false implication, Tyreal! What you described about the effects of d-phenylalanine much more eloquently and more accurately describes my experience. The high itself is not intensified, but the duration is much much longer than without.
 
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tyrael said:
By this I assume you mean the D-phenylalanine (isomer)? I personally found it increased the duration of a noticeable effect* yet no increase of the peak concentration levels let alone for any extended time amount at these levels which seem (concurrently or separately) doubtful. The analgesics properties of D-phenylalanine are thought to be via a reduction in the enkephalin degradation (enzymatically, not important here) of which predominately effects DOR (delta opioid receptors), whilst morphine more closely mimics the endogenous endorphins and hence has affinity to MOR (μ-opioid receptor). DOR of which are not known for their euphoric effect.

I would presume your slow peak (a 7 -8 hour peak on morphine - no matter what ROA - is extremely long!) would be due to the slow degradation of the morphine. And lasting effect more a psychosomatic response. Sorry mate.




* Which makes sense since I'm on bupe which is - in addition to all the other opioid-receptor activity - is a DOR (δ-opioid) receptor antagonist so the prevention of this would cause an extended effect. :)
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Don't forget the effects DPA has on inhibiting decarboxylase, an enzyme that immediately and indiscriminately metabolizes all opiates. DPA should be effective no matter what your opioid DOC is. :)

[P.S. I am impressed with your response, Tyreal. Clearly, you did some research before responding. I greatly appreciate that in my dialogues. If I knew how to throw you some kudos, I would.
Also, let me know your experience with d-phenylalanine, how you took it, side-effects, etc., if it's not too personal.]
 
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I'm an oxycodone user. I used to attain euphoria at 250mg doses orally. What can I do to make it fun again? If I cannot attain the same effects that I did previously, I will end my usage of oxycodone.
 
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Oh I'm sorry that was a misunderstanding

I thought he was personifying oxycodone, the "friend" I was referring to

Love ya chrom
 
Merging this to The Ultimate Opiate Potentiation Thread v2.0 as per mod request.
 
Ho-Chi-Minh said:
Oh I'm sorry that was a misunderstanding

I thought he was personifying oxycodone, the "friend" I was referring to

Love ya chrom
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Love you too HCM :D

It's no worry. I'm just making sure your political power and character are channeled in the correct manner. Being gentle is the preference with novice users :)

Thanks for the move bronson!
 
so if planning on taking 70 mg hydro, then CWE another 150 how much benedryl to take with the first and second dose.

the first dose will be taken 1 hour before the 2nd dose? iv had good luck with 75 mg should i stick to that or no?
 
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