monstanoodle
Bluelight Crew
- Joined
- Aug 13, 2007
- Messages
- 10,910
http://en.wikipedia.org/wiki/Flumazenili'm more interested in the "antidote," especially if tis a reverse gaba agonist. i'm curious to find out if reverse agonists for other NT systems have the same kind of 'reversal' effects as the reverse mu agonist.
It has been used as an antidote in the treatment of benzodiazepine overdoses.[1] It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor.
Many benzodiazepines (including midazolam) have longer half-lives than flumazenil. Therefore, repeat doses of flumazenil may be required to prevent recurrent symptoms of overdosage once the initial dose of flumazenil wears off. It is hepatically metabolised to inactive compounds which are excreted in the urine. Subjects who are physically dependent on benzodiazepines may suffer benzodiazepine withdrawal symptoms, including seizure, upon administration of flumazenil.
It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor.
^ We agree again.
If mr. Nutt is suggesting to us that we can use his neo-alcohol and then take flumazenil before driving and be perfectly happy and safe, well I can only laugh...
Flumazenil is no joke.
This is like saying, "hai look heear. I make a opiate you can use happy, then just take naloxone when u wanna drive sage, I mean safe!"
I don't think he's suggesting that the Flumazenil will be available to the public to take after their night out.
I would sure hope his idea isn't to have the bartender giving out flumazenil to people so they can drive. Anyone addicted to benzodiazepines receiving a drug to instantly knock all the benzos / related compounds off the receptors, sounds like a recipe for seizures imo.
On the article, while it'll be nifty to see what mr nutt comes up with....i have a hard time believing it'll get anywhere.
I notice that he failed to mention the many proven good effects of some kinds of alcohol, such as the cholesterol-reducing properties of red wine.