MurphyClox
Bluelighter
- Joined
- Mar 26, 2008
- Messages
- 1,416
...this was discussed to death.
In short, my 2 cents on this topic:
Trying to make loperamide cross the BBB is not worth the effort. First, most experiments in this direction simply fail. Second, loperamide is suspected to get metabolized in MPP+-like derivatives; something you definitively don't want in your brain. Third, disabling pGP is a baaad idea. The BBB serves a well defined purpose and turning off this said purpose is downright stupid...
- Murphy
In short, my 2 cents on this topic:
Trying to make loperamide cross the BBB is not worth the effort. First, most experiments in this direction simply fail. Second, loperamide is suspected to get metabolized in MPP+-like derivatives; something you definitively don't want in your brain. Third, disabling pGP is a baaad idea. The BBB serves a well defined purpose and turning off this said purpose is downright stupid...
- Murphy