As has been mentioned previously, ethanol is a potentiator of tramadol in that it’s an inducer at CYP2D6. Carisoprodol (Soma) has been mentioned as a potentiator, but to be more concise it’s actually synergistic, as it doesn’t actually potentiate the tramadol. Baclofen is a crappy muscle relaxant and has little, if any, recreational value on its own; I’ve taken 200mg, and although I definitely felt that my muscles were very relaxed (kind of like jello), there was no euphoria. Furthermore, the baclofen made me feel kinda tired, but not sleepy; yet I ended up sleeping for 12 hours and missing a course after going to bed.
This is a HARM REDUCTION site, so please use extreme caution when mixing depressants, as respiratory depression leading to coma or death are very real possibilities.
That said, here’s my experience:
I took a 6 day sabbatical from tramadol. On day 7, I decided to have some fun. Typically, I only feel the SSRI/SNRI effects as I tend to take it on a regular basis- I don’t get any opiate-like effects or sedation. This is great insofar as I can take tramadol as a “booster” to my atomoxetine (Strattera)- I have AD/HD predominantly inattentive type with sub-clinical hyperactive/impulse features. I’m also enrolled in a doctoral program, and the tramadol truly helps me to focus. However, I wanted to take a “vacation” so that I could enjoy the, albeit weak, opiate-like effects of tramadol.
I’ve taken 400mg of IR tramadol over the last 8 hours. Generally, I wouldn’t take any after 5pm, as it would keep me up all night. However, it’s now 11pm, and I’m not feeling stimulated, but rather somewhat opiated. I’ve taken 100mg of tramadol over the last two hours. Over the last two hours, I’ve also consumed 5 standard drinks (Kentucky bourbon), 1400 mg of carisoprodol, and 75mg of baclofen. I’m feeling rather nice. I think I’ll have another drink over the next hour, then 15mg zolpidem subcutaneously before bed.
Good night all