malfunkshun said:this is open again? anyway i never got the chance to reply because i had no net connection when all the fun was going on here and i got bashed pretty good, and some people were pretty cool.
one word here from me and then you guys can have all the fun you want.
i know taking vast amounts of loperamide can't be that good for me, neither is taking vast amounts of any drug. but why would i lie about this? i knew i was taking a risk posting this thread, that there would be haters and bashers and general assholes and there have been those a-plenty. i am not in the habit of getting on message boards and inventing tall tales. i have been here for a good long while and anyone who is half way familiar with me knows that i'm not that kind of person.
some people actually think that this is a placebo i'm feeling. if that was the case, i could get high on any goddamn thing in the medicine cabinet just by talking myself into it. it is a ridiculous suggestion. just absolutely RIDICULOUS. i know an opiate high when i feel one, ok? i snorted an 80 mg oxy once and didn't feel jack shit, and man i REALLY tried to talk myself into a good high with that one.
now... you guys can take it or leave it about the getting high on loperamide. what i mainly would like to stress is that it is a lifesaver for withdrawals. i can't say much for what it would do for somebody trying to kick a hard core H or fentanyl habit but for withdrawing from morphine aka pills or poppy pods and seeds, it is a LIFESAVER. it completely eradicates withdrawals at high doses, minimum 50 mg.
now, is it worth it to you to 'risk' taking that many pills to get rid of withdrawals? thats up to you. from my viewpoint though, loperamide is the same as any other opiate taken at high doses. i'm talking about one time use here, not extended.
right now i am tapering off of it, decreasing by 1 pill a day. in about a month i'll be done with it.
and i'm done with this thread too.
(unless more people who aren't retarded start to reply)
Johnny blue said:Bra honestly if it works for you than great but 2 things
1. You can't convince yourself of a placebo, if you could we'd all be eating gummy bears and getting an opiate buzz while smoking cigs for a sativa high.
2. Snorting an 80 will fuck most people up. Especially compared to pods and seeds and even morphine unless maybe iv. Unless your doing 320mgs of oxy daily or some huge ammount of opiate/opiod you WILL at least feel something.
I myself had previously posted in this thread that i thought that your post was genuine. I thought regardless of the science you were trying to nicely inform the rest of us of a way to get high, however after reading this post I for 1 am calling shennanigans. I really think your reaching to defend this and am pretty positive your flat out lying at least to some degree. A good way I've learned to tell a liar is when someone details an explanation that no one asked for.
Finally, someone who knows what they are talking about. I love you djsim.djsim said:OK, it's the tertiary alcohol that makes loperamide not be able to cross the BBB. Now, why doesn't pseudoephedrine/ephedrine provide the same high as methamphetamine? The difference between meth and (pseudo)ephedrine is only the secondary alcohol at the beta position. You people who get high off loperamide... can you get a meth high off of plain ol Sudafed tabs?
djsim said:OK, it's the tertiary alcohol that makes loperamide not be able to cross the BBB. Now, why doesn't pseudoephedrine/ephedrine provide the same high as methamphetamine? The difference between meth and (pseudo)ephedrine is only the secondary alcohol at the beta position. You people who get high off loperamide... can you get a meth high off of plain ol Sudafed tabs?
The primary obstacle for topical administration of pharmaceuticals is to deliver a topically-applied substance through the stratum corneum layer of the epidermis. The stratum corneum is a highly resistant layer comprised of protein, cholesterol, sphingolipids, free fatty acids and various other lipids as well as living cells. Applicants have discovered a second obstacle which must be overcome, the delivery of a sufficient quantity of the substance through the stratum corneum to achieve a minimum effective concentration in the skin where peripheral opioid receptors, i.e. nerve tissue at the dermal/epidermal junction, are located. Applicants have further discovered that a third obstacle is maintaining a sufficient concentration of the active substance in the skin where peripheral opioid receptors are located for a minimum effective period of time to achieve the desired response. That is, it is not sufficient that a minimum concentration merely be reached; it must be sustained for a minimum time period.
Certain opioids are also known to be antihyperalgesic. As an antihyperalgesic opioid, loperamide hydrochloride is effective in treating pain and hypersensitivity to painful stimuli associated with inflammatory skin conditions. Due to its high affinity for peripheral opioid receptors and poor ability to penetrate the central nervous system, loperamide hydrochloride is an excellent candidate for topical administration of an antihyperalgesic.