I have heard a lot about not mixing alcohol and oxycodone. I find that the best way to do it is to take the pill(s) first and after your feeling the effects, then start drinking a beer. I find that after 10-15mg of Oxycodone, even one beer feels like ten and I don;t need much more than that to feel the perfect combination. Lot's of my friends will start to get sick and sometimes throw up. STart drinking slowly, and try to avoid shots as you don;t know how it will turn out. Liver damage is a given, but if you don;t do this often it shouldn't be a problem. It's different for everyone so always start slow, no reason to hurt yourself for one lowsy fix.